The invention relates to an
adenosine monophosphate
meglumine injection and a preparation method thereof. The preparation process is to take an appropriate amount of water for injection, add
sodium chloride,
cyclic adenosine monophosphate, and
meglumine, stir to dissolve completely, add 0.05-0.2% (W / V)
activated carbon for needles by volume, and stir for 15-30 minutes. Filter to remove carbon, add water for injection to nearly full amount, use
phosphate buffer to adjust the pH value to between 6.0 and 6.5, add water for injection to the full amount, and check that the semi-finished product is qualified, filter,
potting (full
nitrogen gas in the whole process), and extinguish
Bacteria, light inspection, packaging. The method has the advantages of selecting appropriate solvents and additives, improving the
solubility and stability of
meglumine cyclic adenosine monophosphate, and adopting a
terminal sterilization preparation method to effectively ensure the
sterility assurance level of the
drug. The invention has the characteristics of formula composition, simple process, low production cost, strong
drug stability and safety, and the like.