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Garcinolic acid injection and its prepn

A technology for gambogic acid and injection, which is applied in the field of traditional Chinese medicine preparations and can solve the problems of inconvenient clinical use and poor stability

Inactive Publication Date: 2003-11-05
戴建国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The gambogic acid extracted by the above method has anti-tumor effect, and it is also reported that the injection made of gambogic acid is used in anti-tumor research. The injections reported at present mainly have those directly dissolved in water and prepared with boric acid solution. These injections need A large amount of co-solvent is added, the stability is poor, and it is inconvenient to use clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Embodiment 1 formula: 1000 bottles of lyophilized injection, 25g (25 parts by weight) of gambogic acid, 20g (20 parts by weight) of L-arginine, 40g (40 parts by weight) of mannitol, 2000ml (2000 parts by weight) of water for injection .

[0101] Take the prescribed amount of gambogic acid, put it in a suitable container, add an appropriate amount of water for injection (80% of the total volume), stir well, add L-arginic acid to dissolve until clear, add mannitol, stir to dissolve, add 1% injection for injection Charcoal, stir for 30 minutes, decarbonize, add water for injection to a sufficient amount, after the determination of the intermediate content is qualified, under sterile conditions, filter with a 0.22 microporous membrane, and fill the filtrate in 10ml vials, 2ml per bottle, half Stoppering, loading into trays, putting into the freeze-drying box, inserting the temperature sensor, closing the box door, turning on the machine and drying it, sealing it tightly, ta...

Embodiment 2

[0102] Embodiment 2 formula: 1000 bottles of injection, 25g (25 parts by weight) of gambogic acid, 20g (20 parts by weight) of L-arginine, 40g (40 parts by weight) of mannitol, 2000ml (2000 parts by weight) of water for injection.

[0103] Take the prescribed amount of gambogic acid, put it in a suitable container, add an appropriate amount of water for injection (280% of the total volume), stir well, add L-arginine to ultrasonically dissolve until clarified, add mannitol, stir to dissolve, add 1% charcoal for needles , stirred for 30 minutes, decarbonized, added water for injection to a sufficient amount, and after the determination of the intermediate content was qualified, under sterile conditions, filter through a 0.22 microporous membrane, and fill the filtrate in 10ml vials, 2ml per bottle. Embodiment 3 formula: 1000 bottles of freeze-dried injections, 50 g (50 parts by weight) of gambogic acid, 50 g (50 parts by weight) of meglumine or lysine, 100 g (100 parts by weight)...

Embodiment 4

[0105] Embodiment 4 formula: 1000 bottles of injections, gambogic acid 50g (50 parts by weight), meglumine or lysine 50g (50 parts by weight), dextran or sodium chloride 100g (100 parts by weight), water for injection 4000ml (4000 parts by weight).

[0106] Take the prescribed amount of gambogic acid and put it in a suitable container, add an appropriate amount of water for injection (280% of the total volume), stir well, add meglumine or lysine to ultrasonically dissolve until clear, add dextran or sodium chloride, and stir to dissolve , add 1% charcoal for needles, stir for 30 minutes, decarburize, add water for injection to a sufficient amount, after the content of intermediates is determined to be qualified, filter with a 0.22 microporous membrane under sterile conditions, and fill the filtrate in a 10ml vial , 4ml per bottle.

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PUM

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Abstract

The garcinolic acid injection as one kind of Chinese medicine preparation contains garcinolic acid as active component as well as cosolvent, excipient, and water for injection. Its preparation process includes weighing material garcinolic acid in 1-50 weight portions, adding water for injection in 0-4000 weight portions via stirring, adding cosolvent in 1-50 in weight portions before ultrasonic dissolving, adding excipient 1-100 in weight portions through stirring to dissolve, adding active carbon during stirring, eliminating carbon, filtering and packing. The injection may be freeze dried to prepare freeze dried injection. The cosolvent is selected from L-arginine, meglumine and lysine; and the excipient is selected from mannitol, dextran and sodium chloride.

Description

technical field [0001] The invention relates to a gambogic acid preparation for injection and a preparation method thereof, relating to a traditional Chinese medicine preparation, in particular to gambogic acid, a preparation containing it and a preparation method thereof. Background technique [0002] Garcinia cambogia is a dry resin secreted by Garcinia cambogia, which was recorded in the United States Pharmacopoeia, and its active ingredient is mainly gambogic acid. In 1955, Amorosa obtained pure gambogic acid for the first time by making pyridinium salt crystallization. In 1965, the molecular structure was determined with the help of nuclear magnetic resonance, and the research work on gambogic acid continued to deepen. There are many literature reports on the preparation method of gambogic acid, among which there are mainly three. The first route is to soak the garcinia crumbs in acetone overnight, combine the acetone solution to obtain the acetone extract of garcinia ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
Inventor 戴建国
Owner 戴建国
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