Telmisartan tablet composition
A technology of telmisartan and composition, which is applied in the field of telmisartan tablet composition, can solve problems such as poor dissolution rate, inability to obtain shaped solids, strong hygroscopicity, etc.
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Embodiment 1
[0022] Embodiment 1 Telmisartan tablet
[0023] Name of raw material Amount (g)
[0024] Telmisartan 80
[0025] Sodium hydroxide 6.72
[0026] Meglumine 24
[0027] Sorbitol 270
[0028] Calcium hydrogen phosphate 68
[0029] Povidone 20
[0031]
[0032] A total of 2000 pieces
[0033] Preparation:
[0034] 1) Combine sodium hydroxide and meglumine, add 20ml of water to dissolve, then add telmisartan, and add 120ml of ethanol to dissolve, shake and dissolve telmisartan, dry under reduced pressure at 40°C to obtain a white puffy Solid, pulverized through 200 mesh drying, to obtain telmisartan salt powder;
[0035] 2) Sorbitol, calcium hydrogen phosphate, and povidone are pulverized through 100 mesh, and magnesium stearate is crushed through 40 mesh, weighed according to the prescription amount and mixed with telmisartan salt powder evenly;
[0036] 3) The mixed powder is directly compressed into tabl...
Embodiment 2
[0037] Embodiment 2 Telmisartan tablet
[0038] Name of raw material Amount (g)
[0039] Telmisartan 80
[0040] Sodium hydroxide 6.72
[0041] Meglumine 24
[0042] Sorbitol 250
[0043] Calcium hydrogen phosphate 88
[0044] Povidone 20
[0046]
[0047] A total of 2000 pieces
[0048] Preparation:
[0049]1) Take sodium hydroxide and meglumine, add 20ml of water to dissolve, then add telmisartan, and add 120ml of ethanol to dissolve, shake and dissolve telmisartan, spray dry to obtain telmisartan salt powder;
[0050] 2) Sorbitol, calcium hydrogen phosphate, and povidone are pulverized through 100 mesh, and magnesium stearate is crushed through 40 mesh, weighed according to the prescription amount and mixed with telmisartan salt powder evenly;
[0051] 3) The mixed powder is directly compressed into tablets to obtain the product.
Embodiment 3
[0052] Embodiment 3 Telmisartan tablet
[0053] Name of raw material Amount (g)
[0054] Telmisartan 80
[0055] Sodium hydroxide 6.72
[0056] Meglumine 24
[0057] Sorbitol 280
[0058] Calcium hydrogen phosphate 58
[0059] Povidone 20
[0061]
[0062] A total of 2000 pieces
[0063] Preparation method: refer to the method of Example 1.
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