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1061 results about "Methylamines" patented technology
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Derivatives of methylamine (the structural formula CH3NH2).
Chemical method for in-situ large-area controlled synthesis of perovskite type CH3NH3PBI3 membrane material based on lead simple-substance membrane
ActiveCN104250723AHigh purityUniform purityVacuum evaporation coatingSputtering coatingPhysical chemistryMethylamines
The invention relates to a chemical method for in-situ large-area controlled synthesis of a perovskite type CH3NH3PBI3 membrane material based on a lead simple-substance membrane. The method comprises: sputtering the lead simple-substance membrane on the surface of a substrate, then horizontally immersing the substrate material possessing the lead simple-substance membrane in an organic solution containing a simple substance iodine and iodinated methylamine, and performing a constant-temperature reaction to prepare a CH3NH3PBI3 membrane material in situ; or putting the substrate possessing the lead simple-substance membrane in a steam atmosphere of a simple substance iodine to perform iodination to generate a lead iodide membrane, then immersing in an organic solution containing iodinated methylamine, and performing a constant-temperature reaction to prepare the CH3NH3PBI3 membrane material in situ. The method is simple in operation, low in energy consumption and low in cost, and has wide industrial application prospect. The obtained CH3NH3PBI3 membrane is high in purity, uniform in membrane-surface crystal and excellent in crystallinity.
Owner:XUCHANG UNIV +1
Oleanolic acid derivative, and preparation method and purpose thereof
InactiveCN102070697AHigh reaction yieldReduce manufacturing costSteroidsMethylaminesMedicinal chemistry
The invention relates to the field of medicine, in particular to an oleanolic acid derivative shown as a formula I, and pharmaceutically acceptable salts, a preparation method and purpose thereof. The invention also discloses application of the compound shown by the formula I to the preparation of anti-tumor medicine of 2-cyano-3, 12-dioxo oleanane-1, 9(11)-diene-28-carboxylic acid (XI, CDDO), 2-cyano-3, 12-dioxo oleanane-1, 9(11)-diene-28-carboxylic imidazole (XIII, CDDO-Im) and 2-cyano-3, 12-dioxo oleanane-1, 9(11)-diene-28-carboxyl methylamine (XIV, CDDO-MA).
Owner:CHINA PHARM UNIV
Curing agent for low temperature cure applications
InactiveUS20080194776A1Extended drying timeRapid hardness developmentThin material handlingEpoxyLow temperature curing
The present invention provides N,N′-dimethyl secondary diamine polymers including methylamine-terminated poly-(N-methylazetidine) and methylamine-terminated poly-(N-methylazacycloheptane). Amine compositions and amine-epoxy compositions comprising N,N′-dimethyl secondary diamine polymers are also disclosed.
Owner:EVONIK DEGUSSA GMBH
Thermal-reversible self-repair polyurethane membrane and preparation method therefor
The invention discloses a thermal-reversible self-repair polyurethane membrane and a preparation method therefor. Under protection of inert gases, 4,4-diphenylmethane diisocyanate, polycaprolactone glycol and N,N-dimethyl formamide are mixed uniformly, a reaction is carried out at a temperature of 50-60 DEG C, then the solution is cooled to a temperature of less than 5DEG C, 2-furan methylamine is added in the solution, the temperature is risen to 95-105 DEG C, the reaction is carried out for 10-11h, then hyperbranched polysiloxane with maleimide groups is added, the pre-finishing product prepared after the reaction is finished is poured into a die and dried, and a thermal-reversible self-repair polyurethane membrane is obtained. By utilization of the Diels-Alder (DA) reaction, thermal-reversible self-repair of a polyurethane membrane is achieved, the prepared polyurethane membrane has advantages of excellent thermal stability and high hardness, and raw materials have wide sources. The preparation method has characteristics of simple technology, strong practicality, wide applicability and the like.
Owner:SUZHOU UNIV
Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds
InactiveUS20060110439A1Avoid crosslinkingCosmetic preparationsToilet preparationsIothalamate MeglumineLiposome
The present invention relates to methods and compositions for the treatment of skin-related conditions and disorders. In one aspect, the invention features methods and compositions for the transdermal delivery of compounds for the treatment of skin-related conditions and disorders, wherein the compositions include meglumine and a liposome component.
Owner:DYNAMIS THERAPEUTICS
Chemical method for synthesizing perovskite type CH3NH3PbBr3 film material through in-situ large area control based on lead monomer film
ActiveCN105369232AEasy to operateAdapt to the needs of industrial applicationsMetallic material coating processesPhysical chemistryThin membrane
Owner:XUCHANG UNIV
3-methylamine tetrahydrofuran preparation method
ActiveCN106397372ARaw materials are cheap and easy to getThe synthesis process is simpleOrganic chemistryCobalt acetateHydrogenation reaction
The invention provides a 3-methylamine tetrahydrofuran preparation method, wherein 1,4-butenediol is adopted as a raw material and is subjected to cyclization dehydration under the catalysis effect of a solid acid to produce 2,5-dihydrofuran, the 2,5-dihydrofuran reacts with water gas under the catalysis effect of cobalt acetate to produce 3-tetrahydrofuran formaldehyde, and the 3-tetrahydrofuran formaldehyde, ammonia gas and hydrogen gas are subjected to a hydrogenation reaction under the catalysis effect of 5% Pd / C to prepare the target product3-methylamine tetrahydrofuran, wherein the purity is 98.12%, and the total yield is 74.16%. According to the present invention, the preparation method has advantages of cheap and easily available raw materials, less steps, simple operation, high product purity, high yield, less three-waste pollution and production cost reducing, and is suitable for industrial production.
Owner:浙江捷达科技有限公司
Thermally-reversible self-repairing electrostatic dissipation polyurethane membrane and production method thereof
ActiveCN105062040AReversible self-healingAlso has static dissipative propertiesPolyurea/polyurethane coatingsElectrically-conductive paintsPolyurethane membraneDimethyl formamide
The invention discloses a thermally-reversible self-repairing electrostatic dissipation polyurethane membrane and a production method thereof. The method comprises the following steps: uniformly mixing 4,4-diphenylmethane diisocyanate, polycaprolactone glycol and N,N-dimethyl formamide, reacting, cooling to a temperature being smaller than 5DEG C, adding 2-furanmethanamine, reacting, heating to 95-105DEG C, adding maleimido group-containing hyperbranched polysiloxane and functionalized carbon nanotubes, uniformly mixing, reacting the above obtained solution at 50-55DEG C to obtain a pre-finished product, pouring the pre-finished product into a die, and drying to obtain the thermally-reversible self-repairing electrostatic dissipation polyurethane membrane. A Diels-Alder (DA) reaction is used to realize thermal reversing and self repairing of the electrostatic dissipation polyurethane membrane; the electrostatic dissipation polyurethane membrane has the advantages of excellent thermal stability and electrostatic dissipation ability, and wide sources of raw materials; and the production method has the characteristics of simple process, strong practicality and extensive applicability.
Owner:SUZHOU UNIV
Methods for inducing weight loss in a human with materials derived from Citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waster or inedible, such as the leaves, peel and immature, unripe fruit. The materials contain as least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methylamine. Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Owner:ADVANTRA Z INC
Bromhexine hydrochloride freeze-dried injection and preparation method thereof
ActiveCN101502494AImprove stabilityExtend the lifespanOrganic active ingredientsPowder deliveryMegluminePharmaceutical formulation
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a stable bromhexine hydrochloride lyophilized powder injection which is characterized in that the lyophilized powder injection is prepared from the following components: 4g of bromhexine hydrochloride, 110g of mannitol and 2g to 8g of meglumine, wherein, the pH value of citric acid is adjusted to 2.0 to 4.0 and water for injection is added up to 2,000ml. The lyophilized powder injection prepared by the invention has higher stability.
Owner:九瑞健康股份有限公司
Universal support for nucleic acid synthesis
Polysubstituted catechol-based universal solid supports suitable for synthesizing oligonucleotides have been prepared. Following synthesis, cleavage of the oligonucleotide from the solid support and catechol-assisted elimination of the 3′-phosphate group is accomplished by treatment with standard basic media such as ammonium hydroxyde or1 methylamine.
Owner:CTGEN
Pharmaceutically useful salts of carboxylic acid derivatives
A compound selected from one or more of the following: a (1R,2S)-2-hydroxyindan-1-amine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an L-arginine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a tert-butylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a choline salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an adamantylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N-benzyl-2-phenylethanaminium salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N-benzyl-2-(benzylamino) ethanaminium salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; or a tris(hydroxymethyl)methylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.
Owner:ASTRAZENECA AB
Ultraviolet light detector of lead-free double perovskite single crystal and manufactruing method thereof
ActiveCN109830550ASolve the problems caused by biological toxicityImprove stabilityFinal product manufactureSolid-state devicesUltraviolet lightsSilver colloid
The invention discloses an ultraviolet light detector of a lead-free double perovskite single crystal. The detector successively comprises a substrate, the lead-free double perovskite single crystal,an electrode, a silver colloid and a conductive gold wire from bottom to top. The lead-free double perovskite single crystal is formed by A, BI, BIII, and X. A molecular structural formula is A2BIBIIIX6, wherein the A is methylamine (MA) or Cs, the BI is Ag or Na, the BIII is Bi, Sb or In, and the X is Cl or I. A lead-free double perovskite single crystal material is selected from any one of Cs2AgInCl6, Cs2NaInCl6, MA2AgBiI6, and MA2AgSbI6. The type of double perovskite material solves a problem caused by biotoxicity of lead in traditional perovskite and has excellent photoelectric performance. Compared with a traditional perovskite material, the perovskite material of the invention has a high and rapid ultraviolet response. Good performance can be maintained in an air and humidity environment and good stability is achieved.
Owner:JINAN UNIVERSITY
Methylamine halogenated plumbate compound large-size crystal growth method and device
ActiveCN104372412AUniform mass transferAvoid formingPolycrystalline material growthFrom normal temperature solutionsElectrical batteryPhysical chemistry
The invention relates to a methylamine halogenated plumbate compound large-size crystal growth method and device. The crystal growth method is a bottom seed crystal solution cooling process and comprises the following steps: sequentially adding raw materials CH3NH2 and Pb(CH3COOH)2.3H2O into an HX (X is halogen) solution according to the stoichiometric proportion to obtain a precipitate, continuously stirring, heating to completely dissolve the precipitate so as to obtain a clear solution, cooling to the saturation point of the solution, adding the seed crystal, and slowly cooling to perform crystal growth for about 1 month. The invention also relates to a large-size crystal growth device. The prepared CH3NH3PbX3 crystal has favorable light absorption range in the ultraviolet-visible light region, has the advantages of no deliquescence and favorable stability, and is applicable to the fields of solar cells, photoelectricity and the like. Compared with the high-temperature solution volatilization process, the method provided by the invention can obtain the large-size high-quality crystal more easily, and has the advantages of accessible raw materials and low cost.
Owner:SHANDONG UNIV
Catalyst for preparing 1,3-cyclohexanebis(methylamine) by m-xylylenediamine hydrogenation under ammonia reaction conditions
InactiveCN102688766ALow reaction pressureReduce reaction energy consumptionOrganic compound preparationCatalyst activation/preparationFixed bedM-xylylenediamine
The invention discloses a catalyst for preparing 1,3-cyclohexanebis(methylamine) by m-xylylenediamine hydrogenation under ammonia reaction conditions. The catalyst realizes the transformation of m-xylylenediamine and hydrogen into 1,3-cyclohexanebis(methylamine) under ammonia reaction conditions and comprises one or more main active components, one or more auxiliary agents and a carrier. The one or more main active components is / are precious metal Ru or / and Pd. The one or more auxiliary agents are selected from Ni, Cr, Co, Fe and their oxides. The carrier is Al2O3, active carbon or SiO2. In a fixed bed reactor, at a certain temperature, under the action of ammonia pressure and the catalyst, the high activity and high selectivity transformation of m-xylylenediamine and hydrogen into a plurality of amine products comprising 1,3-cyclohexanebis(methylamine) as a main product is realized.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Aryl-substituted chalcones compound, its preparation method and its application
ActiveCN102344351AStrong inhibitory activityOrganic compound preparationKetone active ingredientsFuranAryl
The invention discloses an aryl-substituted chalcones compound, a preparation method and an application. The aryl-substituted chalcones compound has a structure shown as a formula(I) or a formula(II), wherein, R1, R2, R3, R4, R5 are aromatic groups or aromatic groups with a substituent, the aromatic groups are phenyl, furan, thienyl, pyridyl, pyrimidyl, thiazolyl or pyrrolyl, the substituent is one or more selected from hydroxyl, methoxyl, ethoxyl, methyl, ethyl, trifluoromethyl, halogen, amino, methylamino or dimethylamino; R3 is selected from hydrogen, amino or-NHCOCH3. The aryl-substituted chalcones compound introduces the aromatic groups based on a phenyl skeleton to form a structure with steric hindrance, the molecule presents a V-shaped spatial conformation, compared with the current chalcone compounds, and the aryl-substituted chalcones compound has higher inhibitory activity to cancer cells and can be used for preparing the antitumor drugs.
Owner:NEOPANORA BIO TECH ZHUHAI LTD
Novel nano-composite double network hydrogel and preparation method thereof
The invention relates to a novel nano-composite double network hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the steps of: performing a condensation (polycondensation) reaction of amines and epichlorohydrin or polyalcohol and aldehydes in clay solution to obtain a condensate (polycondensate) / clay composite first; and adding a hydrophilic monomer under the action of an initiator and a cross-linking agent to obtain the nano-composite double network hydrogel through free radical crosslinking polymerization, wherein in the condensation (polycondensation) reaction, the amines are selected from dimethylamine, methylamine, ethylamine, propylamine, diethylamine, quadrol, propylene diamine, diethylenetriamine, triethylenetetamine and tetraethylenepentamine, the polyalcohol is selected from glycol, propanediol, glycerol, butanediol, neopentyl glycol, pentaerythritol, polyvinyl alcohol, polyethylene glycol, glucose, sucrose, sorbierite, soluble starch and chitosan, the aldehydes are selected from formaldehyde, malonaldehyde and glutaraldehyde, clay is selected from laponite, bentonite or hydrophilic modified bentonite, and the hydrophilic monomer is selected from acrylic acid, acrylamide, N-Isopropylacrylamide, methacrylic acid, acrylonitrile and propene sulfonic acid. The novel hydrogel has the excellent mechanical strength under the condition of high moisture content.
Owner:XINJIANG UNIVERSITY
Perovskite material based light-emitting diode and preparation method therefor
ActiveCN105609652ASimple processSave raw materialsSolid-state devicesSemiconductor/solid-state device manufacturingN dimethylformamideSurface layer
Owner:HANGZHOU MICROQUANTA SEMICON CO LTD
Boronic acid derivatives and therapeutic uses thereof
Owner:QPEX BIOPHARMA INC
Insecticidal composition containing methylamino abamectin and pyrethroid compound
ActiveCN103004858ALong lastingThe effect of chain killing cockroaches is remarkableBiocideAnimal repellantsAbamectinDefoaming Agents
The invention relates to an insecticidal composition containing methylamino abamectin and pyrethroid compounds. The insecticidal composition is prepared into a microcapsule or a gel bait from a raw material comprising the following components in parts by weight: 1 part of emamectin benzoate, 1-40 parts of pyrethroid, 1-5 parts of vegetable oil, 2-5 parts of oil-phase monomers, 5-20 parts of organic solvents, 5-20 parts of water-phase monomers, 5-12 parts of emulsifying agents, 5-20 parts of attractants, 1-3 parts of auxiliary agents, 0.5-3 parts of defoaming agents, 0.2-30 parts of thickening agents and 18-55 parts of water. The obtained insecticidal composition has the advantages of long persistence on cockroaches and outstanding chain cockroach killing effect.
Owner:北京科润天朗环境技术有限公司
Epoxy resin amine curing agent of N,N′-dimethyl secondary diamine polymer
InactiveUS7666954B2Extended drying timeRapid hardness developmentThin material handlingEpoxyEndcapping
The present invention provides N,N′-dimethyl secondary diamine polymers including methylamine-terminated poly-(N-methylazetidine) and methylamine-terminated poly-(N-methylazacycloheptane). Amine compositions and amine-epoxy compositions comprising N,N′-dimethyl secondary diamine polymers are also disclosed.
Owner:EVONIK DEGUSSA GMBH
Crystal form of fumarate of pyrrole derivative
The invention relates to a crystal form of fumarate of a pyrrole derivative, and concretely relates to a crystal form of 1-[5-(2-fluorophenyl)-1-(prindine-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethamide monofumarate and a preparation method thereof. An X-ray powder diffraction spectrum represented by 2theta angle and the interplanar distance by performing Cu-Ka radiation on the crystal form, and is shown as figure 1. The crystal form is high in purity and good in stability, is applicable to preparation technological process and long-term storage, and also has superiority in industrialized production.
Owner:SUNCADIA PHARM CO LTD +1
Preparation method of Bi-based perovskite quantum dot material
ActiveCN106433619AImprove luminosityAchieve green lightLuminescent compositionsFluorescenceEthyl acetate
The invention discloses a Bi-based perovskite quantum dot material and a preparation method thereof. The method includes the following steps that a mixed solvent of ethyl acetate and DMF is adopted as a precursor solution for dissolving halogenated methylamine and halogenated bismuth, and amine serves as a ligand; normal octane and oleic acid are adopted as an anti-solvent; the anti-solvent is added into the precursor solution, supernate is taken after centrifuging, and then the quantum dot material with the chemical formula being MA3Bi2X9 is obtained, wherein MA=CH3NH3, and X=halogen element (X=Cl or Br or I). By the utilization of the method, the quantum dot material which is free of pollution and adjustable in emission peak can be prepared, the yield of fluorescent light can be remarkably increased, and the stability can be remarkably improved.
Owner:HUAZHONG UNIV OF SCI & TECH
Preparation technology for vonoprazan fumarate
The invention relates to a preparation technology for vonoprazan fumarate. The preparation method comprises: reacting 2'-fluoroacetophenone (II) with ammonium acetate to generate 1-(2-fluorophenyl)ethen-1-amine (III), then reacting with 2-bromopropanal for cyclization for generating 2-(2-fluorophenyl)-4-methyl-1H-pyrrole (IV), reacting the compound IV with 3-pyridinesulfonyl chloride to generate 5-(2-fluorophenyl)-3-methyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole (V), then performing N-bromosuccinimide substitution to generate 5-(2-fluorophenyl)-3-bromomethyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole (VI), and finally performing methylamination reaction and salt forming, so as to obtain vonoprazan fumarate. The method avoids usage of a toxic reagent liquid bromine and hydrogen chloride gas capable of corroding equipment in the prior art, possesses the advantages of simple technological route, mild reaction conditions, controllable operation, environment friendliness and high product yield, and is suitable for large-scale industrialized production.
Owner:SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
Pyrrole ring containing hemifumarate as proton pump inhibitor as well as intermediate and pharmaceutical application thereof
ActiveCN104447491AImprove stabilityImprove biological activityOrganic chemistryDigestive systemN-methylacetamideMethyl group
The invention discloses a pyrrole ring containing hemifumarate which serves as a proton pump inhibitor as well as an intermediate and pharmaceutical application thereof, and particularly discloses a pyrrole ring containing 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide hemifumarate which serves as a proton pump inhibitor and has a formula (I) as shown in the specification, a method for synthesizing the same from 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide and fumaric acid and an preparation intermediate of the 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide hemifumarate. The pyrrole ring containing 2-(3-((2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)phenoxy)-N-methylacetamide hemifumarate disclosed by the invention has good stability, excellent biological activity and a good gastric acid inhibition effect.
Owner:连云港恒运药业有限公司
Indoxacarb and emamectin benzoate-chlorfenapyr pesticidal composition
InactiveCN101263823AOvercoming and delaying drug resistanceSynergistic effect is obviousBiocideArthropodicidesWater dispersibleChlorfenapyr
The invention discloses a pesticide composition which takes indoxacarb and methylamino abamectin benzoate (be called emamectin benzoate for short) as the active component for killing pests. The invention is characterized in that the weight ratio of indoxacarb and memamectin benzoate is (1 to 100): 1, either emulsifiable oil, emulsion in water, microemulsion, suspension agent, wettable powder, or water dispersing granule is made by preparing moderately addition agent and the excipient. The pesticide composition has the advantages of effectively preventing and curing the major pests for the agriculture, being particularly applicable to prevent and cure the pest for the vegetables and cotton, significantly demonstrating less consumption, wide insecticidal spectrum, good drug efficacy, safe use, no hurt to human, livestock, and natural enemies.
Owner:国家农药创制工程技术研究中心
Synthetic method of high-purity bortezomib and intermediate thereof
The invention belongs to the pharmaceutical and chemical fields and particularly relates to a synthetic method of high-purity bortezomib and an intermediate of the high-purity bortezomib. According to the invention, N-(2- pyrazine carbonyl)-L-phenylalanine benzyl ester is obtained from condensation reaction between 2-pyrazine carboxylic acid and L-phenylalanine benzyl ester; then the product is catalyzed and hydrogenated; and then the product is condensed and hydrolyzed with the hydrochloride of (aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-alpha-(2-methyl propyl)-4,6-methano-1,3,2- benzodioxoborane-2-methylamine or trifluoroacetate so that the bortezomib is obtained. The preparation process disclosed by the invention has the advantages of simplicity in operation, high purity and low cost. The bortezomib obtained through the method disclosed by the invention is in the form of white powder or crystals, the content is 99.8% or higher, and the total content of SS- and RR-isomers is not greater than 0.1%.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD
Water soluble salts of organic acid 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine and injection and preparation method thereof
ActiveCN103951652APromote oral absorptionQuick effectOrganic active ingredientsOrganic chemistryChemical synthesisDisease
The invention belongs to the technical field of chemical synthetic medicines and particularly relates to water soluble salts of an organic acid of 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine and an injection thereof for treating gastric acid related diseases and a preparation method thereof. The invention discloses the salts of the organic acid of 5-(2-fluorophenyl)-N-methyl-1-(3-pyridyl sulfonyl)-1H-pyrrole-3-methylamine shown as the following general formula in the specification, wherein n is 1 or 1 / 2 and HA is an organic acid. According to the salts of the organic acid, which are disclosed by the invention, the solubility of the salts in water or an artificial gastric and intestinal juice is far greater than TAK438, and the solubility of pyroglutamate and lactate in water is greater than 1g / mL.
Owner:DONGYING DAOYI BIOLOGICAL MEDICINE TECH CO LTD
Quaternary phosphonium salt pillared layered zirconium phosphate material, and preparation method and application thereof
The invention discloses a quaternary phosphonium salt pillared layered zirconium phosphate material, and a preparation method and an application thereof. The chemical formula of the quaternary phosphonium salt pillared layered zirconium phosphate material is as follows, R is methyl, butyl, phenyl or alkane with the length of a carbon chain of 8-20; X is Cl or Br; and m is 1, and n is 0.00288-0.174462. The preparation method comprises the steps of utilizing methylamine to prop up an interlayer spacing interval of zirconium phosphate, obtaining a methylamine-zirconium phosphate precursor, then adding a quaternary phosphonium salt into the methylamine-zirconium phosphate precursor for continuously carrying out reaction for a certain time, replacing the methylamine in the precursor and obtaining the quaternary phosphonium salt pillared layered zirconium phosphate material with white or light gray external appearance, and the quaternary phosphonium salt pillared layered zirconium phosphate material can be added into plastics, rubber, fibers, coatings, adhesives, paper and other materials for preparing an antibacterial or flame-retardant functional material, and be also used for removing algae in water and governing large-area red tide and water blooms in fresh water.
Owner:JINAN UNIVERSITY
Mixed cation perovskite and preparation method therefor
InactiveCN105702869ARich varietyGood photoluminescent propertiesSolid-state devicesSemiconductor/solid-state device manufacturingHalogenPhotoluminescence
The invention provides a mixed cation perovskite and a preparation method therefor. The mixed cation perovskite is characterized in that the mixed cation perovskite is formed by the mixing of methylamine cation, organic amine cation, metal cation and halogen anion according to a certain ratio. According to the invention, the performance of the prepared perovskite material is detected, and is represented through an X-ray diffraction. The perovskite material is compared with CH3NH3PbI3, thereby obtaining a similar spectrogram. The apparent characteristic peaks can be observed nearby 14.1 degrees, 28.5 degrees, 31.9 degrees, 40.5 degrees and 43.1 degrees, thereby indicating that the new perovskite material is obtained. A UV visible near-infrared spectrophotometer indicates that the absorption spectrum of the material covers the whole visible light range within 800nm. A fluorescence spectrophotometer indicates that the material has good photoluminescence quality, has an apparent fluorescence peak nearby 800nm, and accords with the fluorescence peak of the CH3NH3PbI3. Therefore, the prepared perovskite material is similar to the conventional CH3NH3PbI3, and has the good optical performance.
Owner:SHANGHAI TECH UNIV
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