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58 results about "Caloric restrictions" patented technology
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Calorie restriction, or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients.
Method for improving age-related physiological deficits and increasing longevity
InactiveUS20050100617A1Retarding and reversing age associated oxidative damagePrevent and delay mitochondrial dysfunctionOrganic active ingredientsSenses disorderCaloric restrictionsAntioxidant
A method for mimicking the effects of caloric restriction by administration of a food substrate having carnitine or a carnitine derivative and an antioxidant. The food substrate is capable of modulating gene expression in a way similar to caloric restriction.
Owner:NESTEC SA
Nutritional system and methods for increasing longevity
Disclosed herein are dietary formulations and methods to mimic the physiological, biochemical and gene expression effects of calorie restriction without altering dietary intake. The formulations include combinations of nutrients that have various intended functions in the body, falling into three or more of the following activities; (1) antioxidant activity; (2) inhibition of glycation damage; (3) reduction of body weight and fat; and (4) promotion of high insulin sensitivity and low blood insulin / glucose; and (5) anti-inflammatory activity.
Owner:NESTEC SA
Novel anti aging agents and methods to identify them
ActiveUS20100260733A1Stimulate mitochondrial functionPrevent and treat deteriorationOrganic active ingredientsSenses disorderAge related diseaseHigh-Throughput Screening Methods
The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and / or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
Owner:QI HAIYAN
Dietary supplement and method of using same
InactiveUS20060204599A1Good for weight lossAppetite suppressantBiocideOrganic active ingredientsDietary supplementPhysical performance
A dietary supplement is provided whereby the daily administration of materials derived from the Acacia plants is provided orally to humans for the purpose of producing or maintaining weight loss as well as improving a person's physical performance and increasing the person's lean muscle mass. The Acacia materials include these portions of the plant that are normally considered waste or inedible, such as leaves, bark, and roots. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Acacia material may also be used as a tea. For weight loss and weight control, the materials may also be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as an exercise program.
Owner:WHEAT JARED R
Regulation of appetite, body weight and athletic function with materials derived from citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Owner:STEVENS INSTITUTE OF TECHNOLOGY +1
Method for Extending Lifespan Delaying the Onset of Age-Related Disease
ActiveUS20080279786A1Relieve symptomsAntibacterial agentsCosmetic preparationsCaloric restrictionsAcetic acid
A method and composition for extending the lifespan of an individual and delaying the onset of age-related disease is provided. The method includes the administration of an effective dose of oxaloacetate, wherein the oxaloacetate acts to mimic the cellular conditions obtained under caloric restriction to provide similar benefits. The invention further includes methods and compositions for reducing the incidence or treatment of cancer. Compositions and methods for reducing body fat by administering an effective amount of oxaloacetate are likewise provided. Compositions for DNA repair in UV damaged cells is provided are also provided. Similarly, a method for treating a hang-over comprising administering an effective amount of oxaloacetate is disclosed.
Owner:B CASH ALAN
Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose
InactiveUS20080214479A1Promote resultsLower blood sugar levelsBiocideMetabolism disorderCaloric restrictionsActive agent
A method of obtaining beneficial biological results associated with caloric restriction may be gained by administration of a composition containing at least one active agent which blocks metabolism of glucose as a source of energy in cells in glucose metabolism blocking effective amounts to an animal in need thereof.
Owner:MARS INC +2
Methods for inducing weight loss in a human with materials derived from Citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waster or inedible, such as the leaves, peel and immature, unripe fruit. The materials contain as least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methylamine. Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Owner:ADVANTRA Z INC
Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity
InactiveUS20090169585A1Increase concentrationHigh activityBiocideHydroxy compound active ingredientsCancer preventionPhytic acid
The present invention relates to a resveratrol-containing composition capable of modulating gene expression to an extent greater than that observed with resveratrol alone or with calorie restriction. The invention particularly pertains to such resveratrol-containing compositions that comprise resveratrol, a chelator, hyaluronic acid, and / or vitamin D and which upon administration to a recipient, increases the concentration or activity of a survival / longevity gene product and / or decreases the concentration or activity of a gene product that induces or causes cellular damage. Most preferably, the resveratrol-stabilizing composition will comprise the chelator phytic acid (inositol hexaphosphate; IP6), hyaluronic acid, and vitamin D. The invention further pertains to the use of such compositions in the treatment or prevention of cancer, cardiovascular disease, diseases associated with aging, and other conditions and illnesses.
Owner:RESVERATROL PARTNERS
Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose
InactiveUS20060100162A1Promote resultsLower blood sugar levelsBiocideMetabolism disorderCaloric restrictionsActive agent
A method of obtaining beneficial biological results associated with caloric restriction may be gained by administration of a composition containing at least one active agent which blocks metabolism of glucose as a source of energy in cells in glucose metabolism blocking effective amounts to an animal in need thereof.
Owner:THE LAMS +1
Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose
InactiveUS20060116330A1Non-reducing characterAvoid utilizationBiocideHydroxy compound active ingredientsCaloric restrictionsMetabolite
Disclosed herein are methods of using glucose anti-metabolites to alter utilization of glucose or other energy sources and to mimic metabolic effects of caloric restriction. In particular, in one embodiment herein, methods of enhancing longevity in an animal are described, the methods comprising administration of a composition comprising a glucose anti-metabolite to the animal. In another embodiment, methods of enhancing longevity in an animal are described, the methods comprising administration of a composition comprising avocado extract, wherein the avocado extract comprises mannoheptulose. In yet another embodiment, methods of enhancing longevity in an animal are described, the methods comprising administration of a composition comprising mannoheptulose.
Owner:IAMS
Compositions for weight management
InactiveUS20080004254A1Prevent and reduce weight gainBiocideMetabolism disorderDyslipidemiaHalf-life
Owner:MOR RES APPL LTD
Compositions for weight management
ActiveUS20060148787A1Prevent and reduce weight gainImprove efficiencyBiocidePeptide/protein ingredientsDyslipidemiaCompulsive eating
Methods and compositions for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed. The methods and compositions can be efficiently used for treating conditions such as overeating, overweight, obesity, binge eating disorder, night eating syndrome, obsessive eating, compulsive eating and bulimia, as well as conditions associated with metabolic derangement such as dyslipidemia and for preventing or reducing weight gain due to factors such as drug use, cessation of smoking, and the like in a human subject.
Owner:OTOLANUM
Methods of evaluating the dynamics of caloric restriction and identifying caloric restriction mimetics
InactiveUS20050013776A1Rapidly reversibleInduced fastMicrobiological testing/measurementIn-vivo testing preparationsCaloric restrictionsBiochemistry
A method of evaluating the dynamics of caloric restriction (CR). In one embodiment, a method of evaluating the dynamics of CR comprises obtaining control data from an administration of a long-term control diet program. Each of several mammalian sample groups is subjected to a CR diet program for a different amount of time. The effect of CR between each of the several mammalian sample groups and the control data are compared to each other. Additionally, the effects among members of CR among the several mammalian sample groups are compared to each other.
Owner:RGT UNIV OF CALIFORNIA
mTOR PATHWAY OPTIMIZED NUTRITIONAL COMPOSITIONS
ActiveUS20120082760A1Avoid stimulationLow costMilk preparationFood preparationBiotechnologyProtein materials
Method of reducing the mTOR pathway stimulating activity of amino acid containing nutritional materials. This method comprises treating an enzymatically hydrolysed protein material such as casein, whey, or soy protein with at least one enzyme capable of converting mTOR pathway stimulating amino acids and amino acid residues, such as leucine or methionine, into alternate chemical entities that do not stimulate or stimulate to a significantly lesser degree the mTOR pathway, while preserving the non-mTOR stimulating amino acids. These one or more alternate chemical entities should ideally be suitable for consumption, or alternatively be capable of being removed from the treated material through low cost extraction or conversion techniques. The material may then be sold as is, or alternatively packaged with low glycemic carbohydrates, healthy lipids, vitamins, and flavors and sold as a variety of different food products intended for an artificial diet intended to mimic the effects of caloric restriction.
Owner:ROSEDALE RONALD E
Methods for inducing weight loss in a human with materials derived from citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Owner:ADVANTRA Z INC
Interventions to mimic the effects of calorie restriction
InactiveUS20030124540A1Affecting responseLess in CRBioreactor/fermenter combinationsBiological substance pretreatmentsCaloric restrictionsIntervention measures
Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.
Owner:RGT UNIV OF CALIFORNIA
Resveratrol-Containing Compositions and Methods of Use for Treatment of Macular Degeneration
InactiveUS20140363502A1Preserving abilityEasily damagedBiocideHydroxy compound active ingredientsCancer preventionPhytic acid
Owner:RESVERATROL PARTNERS
Methods of food intake management
InactiveUS20060084686A1Prevent and reduce weight gainBiocideMetabolism disorderDyslipidemiaMetabolic derangement
Methods for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed. The methods can be efficiently used for treating conditions such as overeating, overweight, obesity, binge eating disorder, night eating syndrome, obsessive eating, compulsive eating and bulimia, as well as conditions associated with metabolic derangement such as dyslipidemia.
Owner:MOR RES APPL LTD
Novel Anti-aging agents and methods to identify them
ActiveUS20120071349A1Prevents deterioration of mitochondriaInhibit deteriorationOrganic active ingredientsCosmetic preparationsCaloric restrictionsAge related disease
The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and / or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
Owner:QI HAIYAN
Compositions for weight management
InactiveUS20080051440A1Prevent and reduce weight gainImprove efficiencyBiocideMetabolism disorderDyslipidemiaCompulsive eating
Methods and compositions for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows am efficient treatment regime thereof are disclosed. The methods and compositions can be efficiently used for treating conditions such as overeating, overweight, obesity, binge eating disorder, night eating syndrome, obsessive eating, compulsive eating and bulimia, as well as conditions associated with metabolic derangement such as dyslipidemia and for preventing or reducing weight gain due to factors such as drug use, cessation of smoking, and the like in a human subject.
Owner:MOR RES APPL LTD
Omega-3 fatty acid nutriceutical composition and optimization method
ActiveUS20120321602A1Increase heightGood health effectBiocideNervous disorderCaloric restrictionsMembrane fluidity
A novel omega-3 fatty acid / lipid based nutraceutical composition and a method of optimizing said omega-3 fatty acid / lipid based nutraceutical composition. The nutraceutical composition and method is based on the insight that different forms of high omega-3 fatty acid lipids (e.g. triglyceride form, ethyl ester form, free fatty acid form, phospholipid form) have different molecular modes and levels of action. Specifically the phospholipid form is likely more effective at promoting membrane fluidity and permeability, while the free fatty acid form is likely more effective at regulating cell receptors, such as the PPARĪ± receptors, that are responsible for various metabolic effects including lipid metabolism. The desirability of producing omega-3 compositions that may act synergistically and thus more robustly to improve health and to some extent mimic markers of life extension such as shown by caloric restriction, along with specific optimization methods, markers, and compositions are taught.
Owner:WESTBY FIONA C
Methods for increasing the muscle mass of a human with materials derived from citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Owner:ADVANTRA Z INC
Mimicking the metabolic effects of caloric restriction by administration of glucose Anti-metabolites
InactiveUS20090253642A1Non-reducing characterAvoid utilizationBiocideMetabolism disorderCaloric restrictionsPhysiology
Methods of maintaining and / or attenuating a decline in the quality of life of a mammal comprising the step of administering to the mammal a composition comprising an effective amount of mannoheptulose wherein the effective amount of mannoheptulose provides a dosage to the mammal on a daily basis from about 0.001 gram per kilogram of body weight of the mammal to about 1 gram per kilogram of body weight of the mammal.
Owner:IAMS +1
Compositions for weight management
InactiveUS20080003306A1Prevent and reduce weight gainBiocidePeptide/protein ingredientsDyslipidemiaHalf-life
Methods and compositions for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed. The methods and compositions can be efficiently used for treating conditions such as overeating, overweight, obesity, binge eating disorder, night eating syndrome, obsessive eating, compulsive eating and bulimia, as well as conditions associated with metabolic derangement such as dyslipidemia and for preventing or reducing weight gain due to factors such as drug use, cessation of smoking, and the like in a human subject.
Owner:MOR RES APPL LTD
Interventions to mimic the effects of calorie restriction
InactiveUS20030224360A9Extend your lifeReduce morbidityBioreactor/fermenter combinationsBiological substance pretreatmentsCaloric restrictionsIntervention measures
Owner:RGT UNIV OF CALIFORNIA
Dietary supplement system for multifunctional anti-aging management and method of use
A dietary supplement system includes a dietary supplement composition for oral administration by an individual in the morning, the composition, including (a) a telomere maintenance complex including: Purslane extract (aerial parts); Turmeric rhizome extract (95% curcuminoids); Quercetin dehydrate, Cayenne pepper fruit; Vanadium (as vanadyl sulfate); Fenugreek seed; Astragalus root extract, Omega fatty acid complex including linoleic acid; alpha-linolenic acid; oleic acid borage seed oil gamma-linolenic acid), evening primrose oil fish body oil (eicosapentaenoic acid; docosahexaenoic acid); (b) a calorie restriction mimetics and gene expression complex including Trans-resveratrol (from Polygonum cuspidatum root extract); Pterostilbene Fisetin 50% (Buxus microphlla Sieb (stem and leaf; Alpha lipoic acid, Coenzyme Q-10, Betaine HCl, Sulfur (from methylsulfonylmethane); L-Carnitine tartrate; L-Carnitine HCl, and (c) a free radical scavenger complex, including Green tea leaf extract catechin and polyphenols); Anthocyanins (from bilberry fruit and grape skin extracts).
Owner:LIFE SCI INT
Omega-3 fatty acid nutriceutical composition and optimization method
ActiveUS8697676B2Good fluidityImprove permeabilityBiocideNervous disorderTG - TriglyceridePhospholipid
A novel omega-3 fatty acid / lipid based nutraceutical composition and a method of optimizing said omega-3 fatty acid / lipid based nutraceutical composition. The nutraceutical composition and method is based on the insight that different forms of high omega-3 fatty acid lipids (e.g. triglyceride form, ethyl ester form, free fatty acid form, phospholipid form) have different molecular modes and levels of action. Specifically the phospholipid form is likely more effective at promoting membrane fluidity and permeability, while the free fatty acid form is likely more effective at regulating cell receptors, such as the PPARĪ± receptors, that are responsible for various metabolic effects including lipid metabolism. The desirability of producing omega-3 compositions that may act synergistically and thus more robustly to improve health and to some extent mimic markers of life extension such as shown by caloric restriction, along with specific optimization methods, markers, and compositions are taught.
Owner:WESTBY FIONA C
Regulation of athletic function with materials derived from citrus varieties
Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Owner:ADVANTRA Z INC
Method for extending lifespan delaying the onset of age-related disease
A method and composition for extending the lifespan of an individual and delaying the onset of age-related disease is provided. The method includes the administration of an effective dose of oxaloacetate, wherein the oxaloacetate acts to mimic the cellular conditions obtained under caloric restriction to provide similar benefits. The invention further includes methods and compositions for reducing the incidence or treatment of cancer. Compositions and methods for reducing body fat by administering an effective amount of oxaloacetate are likewise provided. Compositions for DNA repair in UV damaged cells is provided are also provided. Similarly, a method for treating a hang-over comprising administering an effective amount of oxaloacetate is disclosed.
Owner:B CASH ALAN
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