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Gingko lactone powder injection and its preparation method

A technology of ginkgolide and powder injection, which is applied in the field of pharmaceutical preparations of ginkgolide extracted from Chinese herbal medicine, can solve the problems of reduced bioavailability, slow drug efficacy, and poor stability, and achieve improved utilization, high drug efficacy, and increased The effect of stability

Active Publication Date: 2004-12-29
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the ginkgolide preparations in the prior art have the disadvantages of reduced bioavailability, poor stability, slow drug curative effect, and high cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1. A kind of ginkgolide powder injection, its main component and weight content are,

[0010] Ginkgolide 50.0g

[0011] Meglumine 15.0g

[0012] Hydroxypropyl-β-cyclodextrin 350.0g is made into 5000ml injection, divided into 1000 tubes, freeze-dried, and obtained.

Embodiment 2

[0013] Example 2. A kind of ginkgolide powder injection, its main component and weight content are,

[0014] Ginkgolide 50.0g

[0015] Meglumine 10.0g

[0016] Hydroxypropyl-β-cyclodextrin 300.0g is made into 5000ml injection, divided into 1000 tubes, and freeze-dried to obtain.

Embodiment 3

[0017] Example 3. A kind of ginkgolide powder injection, its main component and weight content are,

[0018] Ginkgolide 50.0g

[0019] Meglumine 20.0g

[0020] Hydroxypropyl-β-cyclodextrin 400.0g made into 5000ml injection, divided into 1000 tubes, freeze-dried to obtain.

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PUM

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Abstract

The present invention discloses one kind of bilobalide powder for injection and features its composition including bilobalide, meglumine and hydroxypropyl-beta-cyclodextrin in the weight ratio of 1 to 0.2-0.5 to 6-9. The present invention also discloses the preparation process of the bilobalide powder for injection. The bilobalide powder for injection has supplementary material capable of dissolving bilobalide completely without destroying its structure, and bilobalide as the main material is slightly soluble in water and easily soluble in acetone. The key point of the present invention is to select hydroxypropyl-beta-cyclodextrin as the solubilkizing supplementary material to raise the solubility of bilobalide greatly, and this raises the bioavailability of bilobalide and the curative effect of the injection greatly.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of ginkgolide extracted from Chinese herbal medicine, in particular to a ginkgolide powder injection; the invention also relates to a preparation method of the powder injection. Background technique [0002] Ginkgolide is an effective substance extracted from Ginkgo biloba leaves, and the extraction method of ginkgolide has been reported in detail. Ginkgolide, as a highly active platelet antagonist factor, may be developed into a clinical clinical trial that plays an important role in pathological processes such as thrombosis, organ transplant rejection, senile dementia, acute inflammation, cardiac allergy, and shock caused by endotoxin. medicine. Since ginkgolide is slightly soluble in water, the selection of excipients with solubilizing effect is the key to the molding process. Most of the ginkgolide preparations in the prior art have the disadvantages of reduced bioavailab...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/19A61K31/365A61P9/00A61P9/10
Inventor 肖伟戴翔翎凌娅王振中尚强毕宇安
Owner JIANGSU KANION PHARMA CO LTD
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