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Meglumine cyclic adenosine injection and preparation technique thereof

A technology for meglumine cyclophosphate and adenosine cyclophosphate, which is applied in the field of meglumine cyclophosphate injection and its preparation, can solve the problems of turbidity, deterioration of medicinal liquid, complicated preparation process, etc. Direct effect, improving stability and safety

Inactive Publication Date: 2009-06-17
湖北安邦医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the freeze-dried preparation is very complicated, and sometimes meglumine cyclic adenosine monophosphate will gradually precipitate out after reconstitution, making the liquid medicine deteriorate and turbid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Cyclic adenosine monophosphate meglumine injection and its preparation process, its composition includes: the water injection made of cyclic adenosine monophosphate, meglumine and stability regulator citric acid, its parts by weight are cyclic adenosine monophosphate 37.67, glucose Methylamine 22.33, citric acid 3.15, pH value 6.2, properties are colorless or almost colorless clear liquid. The preparation process is as follows: put citric acid into a magnetic stirring tank, add 50% of the prepared amount of water for injection and stir to dissolve, then add cyclic adenosine monophosphate and meglumine to the above solution, stir to dissolve, and add by volume 0.02% activated charcoal for needles, stirred for 30 minutes, coarsely filtered to remove charcoal, and obtained meglumine cyclic adenosine monophosphate solution for later use. Add nearly full amount of water for injection, measure the pH value, adjust the pH value to 6.0-6.5 with 10% sodium hydroxide solution, ad...

Embodiment 2

[0013] Cyclic adenosine monophosphate meglumine injection and its preparation process, its composition includes: the water injection made of cyclic adenosine monophosphate, meglumine and stability regulator citric acid, its parts by weight are cyclic adenosine monophosphate 47.09, glucose Methylamine 27.91, citric acid 3.15, pH value 6.4, properties are colorless or almost colorless clear liquid. The preparation process is as follows: put citric acid into a magnetic stirring tank, add 50% of the prepared amount of water for injection and stir to dissolve, then add cyclic adenosine monophosphate and meglumine to the above solution, stir to dissolve, and add by volume 0.02% activated charcoal for needles, stirred for 30 minutes, coarsely filtered to remove charcoal, and obtained meglumine cyclic adenosine monophosphate solution for later use. Add nearly full amount of water for injection, measure the pH value, adjust the pH value to 6.0-6.5 with 10% sodium hydroxide solution, ad...

Embodiment 3

[0015] Cyclic adenosine monophosphate meglumine injection and its preparation process, its composition includes: the water injection made of cyclic adenosine monophosphate, meglumine and stability regulator citric acid, its parts by weight are cyclic adenosine monophosphate 56.505, glucose Methylamine 33.495, citric acid 3.15, pH value 6.1, properties are colorless or almost colorless clear liquid. The preparation process is as follows: put citric acid into a magnetic stirring tank, add 50% of the prepared amount of water for injection and stir to dissolve, then add cyclic adenosine monophosphate and meglumine to the above solution, stir to dissolve, and add by volume 0.02% activated charcoal for needles, stirred for 30 minutes, coarsely filtered to remove charcoal, and obtained meglumine cyclic adenosine monophosphate solution for later use. Add nearly full amount of water for injection, measure the pH value, adjust the pH value to 6.0-6.5 with 10% sodium hydroxide solution, ...

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Abstract

The present invention relates to an adenosine cyclophosphate injection and a preparing process thereof. According to the invention, acidum citricum is added into a magnetic stirring pot. Injection water with confect amount of 50% is added and dissolved. The adenosine cyclophosphate and meglumine are added into the solution. The obtained solution is mixed to be dissolved. The 0.02% of activated carbon with needle use in volume is added. The mixture is mixed for 30 minutes. The mixture is preliminarily filtered fro removing carbon. The adenosine cyclophosphate injection is prepared for standby. The injection water is added to the total amount. The pH value is adjusted to 6.0-6.5 by sodium hydroxide solution with concentration of 10%. The colorless transparent injection is prepared. The adenosine cyclophosphate injection of the invention not only has the advantages of straight function, high speed, etc., but also has the advantages of little adverse effect, normal temperature transportation and normal preserving, thereby increasing the stability and safety of the product.

Description

technical field [0001] The invention relates to a preparation method of chemical medicines, in particular to an adenosine cyclic monophosphate meglumine injection and a preparation process thereof. Background technique [0002] Since meglumine cyclic adenosine is slightly soluble in water, adding meglumine to meglumine cyclic adenosine can increase its solubility. However, in the solution of meglumine cyclic adenosine Phosphate meglumine will gradually precipitate out, causing the liquid to deteriorate and become turbid. If the change is small, it will be difficult to detect. If it is given to the patient, it will cause serious adverse reactions to the patient, thereby affecting the curative effect of the drug, and at the same time affecting the safety of the drug. Therefore, in order to improve the safety of medication and reduce the occurrence of adverse drug reactions, many manufacturers make meglumine cyclic adenosine monophosphate into freeze-dried preparations for eas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7076A61K31/133
Inventor 柯少鸿
Owner 湖北安邦医药有限公司
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