The invention discloses a composition for preventing and treating hypertrophic scars, and a drug and application thereof. The composition comprises the following components in parts by weight: 200-250 parts of silicone oil, 100-150 parts of glycerinum, 40-80 parts of white oil, 2-15 parts of cetostearyl alcohol, 10-25 parts of tween 80, 2-15 parts of stearic acid, and 1-10 parts of carbomer. The composition for preventing and treating hypertrophic scars disclosed by the invention is simple to prepare, low in cost, free from preservative, steady in physicochemical property, exquisite, uniform and long in expiration date; when being used, the composition is directly coated on a wound; therefore, the composition is convenient and practical; pruritus at an affected part in the treatment process can be obviously lightened; therefore, the original colour of skin can be restored; chromatosis is avoided; obvious scars do not exist; formation of hypertrophic scars after operations, burns, scalds and trauma can be effectively prevented; and the composition has good curative effect on formed hypertrophic scars.