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Breathable itching-relieving antisepsis scar treating paster and preparation method thereof

A technology for treating plasters and scars. It is applied in the direction of medical formulas, medical preparations containing active ingredients, and devices that make medicines into special physical or ingestible forms. It can solve the problems of poor air permeability, easy bacterial growth, and poor drainage effect. And other issues

Active Publication Date: 2014-02-05
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional silicone membrane has poor air permeability and poor drainage effect, and is prone to concurrent bacterial growth and local infection.

Method used

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  • Breathable itching-relieving antisepsis scar treating paster and preparation method thereof
  • Breathable itching-relieving antisepsis scar treating paster and preparation method thereof
  • Breathable itching-relieving antisepsis scar treating paster and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0024] The present invention also provides a preparation method of an air-permeable anti-itch antibacterial scar treatment plaster, comprising the following steps:

[0025] a. Ingredients: Prepare raw materials according to the following weight ratio: silicone 97.9%, menthol 1%, borneol 1%, heparin sodium 0.05%, nano silver 0.05%; add nano silver to N,N-dimethylformamide DMF , and ultrasonically disperse; then dissolve silicone, menthol, borneol, and heparin sodium; add a porogen with a particle size of 50-75 μm to the aforementioned solution, so that the final concentration of the porogen is 500g / L; Stir for 15 to 20 minutes;

[0026] b. Passing through the mold: degas the suspension obtained in step a for 20-30 minutes at a vacuum of 0.6-0.8 MPa; pour the defoamed suspension into the mold, cast evenly, pass the amount of the suspension Control the thickness of the liquid embryonic membrane to be 1.5mm;

[0027] c. Molding: Place the mold containing the liquid embryonic mem...

Embodiment 1

[0036] Embodiment 1 The preparation of breathable antipruritic antibacterial scar treatment patch

[0037] Add nano-silver antibacterial powder into N,N-dimethylformamide (DMF), ultrasonically disperse for 10-15 minutes, power 300w, and prepare a solution with a final concentration of nano-silver of 0.05%. Then silicone granules, menthol, borneol, and heparin sodium granules were dissolved therein so that the final concentrations were 97.9%, 1.0%, 1.0%, and 0.05%, respectively. Then sieve the porogen pulverized by the pulverizer, and pour the particles with a particle size between 50 and 75 μm into the prepared solution so that the concentration of the porogen is 500g / L; In a mixer with a thermometer, mechanically stir at room temperature for 20 min. After degassing for 30 minutes at a vacuum degree of 0.6-0.8 MPa, it is poured into a polytetrafluoroethylene mold, cast evenly, and the thickness of the liquid embryo film is controlled to be 1.5 mm by the amount of the suspensi...

Embodiment 2

[0038] Example 2 Performance Test of Breathable Antipruritic Antibacterial Scar Therapy Patch

[0039] 1. Use a scanning electron microscope to observe the surface pore structure of the breathable anti-itch antibacterial scar treatment patch: cut the treatment patch into a small circular piece with a diameter of 3 cm, wrap it in a gold-palladium mixture in a vacuum environment, and then observe it under a scanning electron microscope. See the results for details figure 1 shown.

[0040] 2. The average pore diameter of the holes on the surface of the air-permeable anti-itch antibacterial scar treatment plaster is calculated by software from the scanning electron microscope observation results, and the porosity is 20,000-30,000 / mm2. See the results for details figure 2 .

[0041] 3. Measurement of air permeability: Cut the treatment patch into a disc shape with a diameter of 35mm, cover the opening of a cylindrical cup with a diameter of 34mm filled with 10mL ultrapure water...

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Abstract

The invention belongs to the technical field of treating skin scars, and particularly relates to a breathable itching-relieving antisepsis scar treating paster and a preparation method thereof. The technical problem to be solved is to provide a new choice for treating a hypertrophic scar. According to the technical scheme, the breathable itching-relieving antisepsis scar treating paster is prepared from the following active ingredients in percentage by weight: 97.9% of silicone, 1% of mint, 1% of borneol, 0.05% of heparin sodium, and 0.05% of nanosilver. The invention further provides a preparation method for the breathable itching-relieving antisepsis scar treating paster. The treating paster provides a new choice for treating the scar.

Description

technical field [0001] The invention belongs to the technical field of skin scar treatment, and in particular relates to a breathable antipruritic antibacterial scar treatment patch and a preparation method thereof. Background technique [0002] Different degrees of scar hyperplasia will inevitably occur after skin wounds are healed due to various reasons. Although the medical community has done a lot of research on the mechanism of the occurrence and development of hypertrophic scar, the mechanism is still unclear up to now. The hypertrophic scar not only affects the appearance of the wound, but also affects the function of the affected area. At the same time, during the development of the scar, it is always accompanied by symptoms and discomforts such as fever and itching in varying degrees, which in turn affects the quality of life of the patient. How to prevent and treat scar hyperplasia, especially how to alleviate discomfort such as heating and itching in the process ...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K9/70A61P17/02A61P17/04A61J3/00A61K31/045A61K31/727A61K31/80
Inventor 罗高兴吴军夏和生贺伟峰徐瑞詹日兴
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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