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Agent for Treating Skin Aging and Scars

Inactive Publication Date: 2011-02-03
LABO JUVERSA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The object of the present invention is to provide an agent for preventing and tre

Problems solved by technology

Aging of skin such as skin wrinkle, sagging and loose skin, pigmentation, depigmentation, skin thinning, decrease of skin viscoelasticity, etc. influences seriously the quality of life (QOL) particularly in women, and when the degree is severe, it sometimes becomes an obstacle in social life.
On the other hand, similarly to aging of skin, scars of skin such as hypertrophic scars and keloid etc., also greatly influence the QOL of the patient, and it sometimes becomes an obstacle in social life depending on the degree or site (face, etc.) of the scar.
Further, wide scar or atrophic scar often remains even when the changes are calmed down, and the QOL of the patient was lowered for a long period of time in any of the cases.
As stated in the above, it can be said that aging of skin and scar of skin are not only cosmetic and functional problems of the patient but social problems such as QOL of the patient, etc.
However, neither of the above-mentioned skin care product nor skin external preparation could prevent and treat aging of skin sufficiently.
However, these therapeutic methods require quite a long time period, and even by utilizing all of the therapeutic methods, it was difficult to treat sufficiently the scars.
However, effect of bFGF without being combined with HGF when a scar has already been formed has not been reported yet.
However, it cannot be said that the effect is satisfactory, even from a clinical standpoint (Singer, A. J. and Clark, R. A. F. New Eng. J. Med., 341, 738-746, 1999).
Further, the aforementioned peptide factors (bFGF, PDGF) are pharmaceutical compositions that can be used only for topical application and topical spraying, and almost no effect or efficacy can be expected from a systemic administration such as intravenous administration.”

Method used

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  • Agent for Treating Skin Aging and Scars
  • Agent for Treating Skin Aging and Scars
  • Agent for Treating Skin Aging and Scars

Examples

Experimental program
Comparison scheme
Effect test

example 1

[Production of the Formulation of the Present Invention]

[0045]500 μg of the freeze-dried commercial product of bFGF (Trafermin: KAKEN PHARMACEUTICAL CO., LTD.) was dissolved into 50 ml of distilled water for injection, to prepare 10 μg / ml of bFGF solution. The bFGF solution was dispensed into sterilized polypropylene containers by 1 ml each, and was immediately cryopreserved in a freezer of −70° C. In the following tests, a bFGF solution prepared by naturally melting the cryopreserved product at room temperature was used as the formulation of the present invention (agent for preventing and treating skin aging, or agent for treating skin scar).

example 2

[Test for Confirming the Effect of Preventing and Treating Aging of Skin]

case 1

1. Case 1

[0046]0.8 ml of the formulation of the present invention (0.2 ml per 1 cm2 of the skin of the treatment site) was injected to the dermis of the target site to be treated of a 61 years-old woman (Case 1) (lateral angle of right eye) (FIG. 1). When the treatment site was observed 1 month after the treatment, several longer wrinkles in the lateral angle of right eye and plural small wrinkles at the corner of the eyes which have been confirmed before the treatment (FIG. 2, upper left) had disappeared, and the skin texture was also clearly improved (FIG. 2, upper right). Further, after 2 months from the treatment, not only the improved condition was maintained, but improvements were observed including that skin tugor was enhanced and the eye areas were plumped up, and lateral angle of the eye was lifted up (FIG. 2, lower left). Further, 3 months after the treatment, further progress of the tendency of improvement was observed (FIG. 2, lower right).

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Abstract

It is to provide an agent for preventing and treating skin aging, or an agent for treating skin scar that can exert a sufficient effect. An agent for preventing and treating skin aging comprising bFGF for treating aging of the skin that is administered intradermally or subcutaneously, or an agent for treating skin scar comprising bFGF for treating scar of skin that is administered intradermally or subcutaneously is utilized. Preferred examples of aging of skin include skin wrinkle, pigmented spot, sagging skin, rough skin, skin thinning, decrease of skin viscoelasticity, etc., and preferred examples of scar include keloid, hypertrophic scar, scar contracture, etc.

Description

TECHNICAL FIELD[0001]The present invention relates to an agent for preventing and treating aging of skin, and an agent for treating scars of skin.BACKGROUND ART[0002]Aging of skin such as skin wrinkle, sagging and loose skin, pigmentation, depigmentation, skin thinning, decrease of skin viscoelasticity, etc. influences seriously the quality of life (QOL) particularly in women, and when the degree is severe, it sometimes becomes an obstacle in social life. Conventionally, most of aging of skin was thought to be a so-called physiological aging which progresses with increasing age. However, recently, it is thought that almost all aging of skin is caused by aging due to exposure to ultraviolet rays (so-called photoaging). When skin is exposed to ultraviolet rays, mechanisms including inflammation, followed by disruption of dermal tissues and functional decrease of fibroblast cells are induced, and aging of skin such as described in the above progress.[0003]On the other hand, similarly t...

Claims

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Application Information

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IPC IPC(8): C07K14/50
CPCA61K8/66A61K2800/91A61K9/0021A61K38/1825A61K9/0019A61Q19/08A61P17/00A61P17/02A61P17/16
Inventor ONO, ICHIRO
Owner LABO JUVERSA
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