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Compound liquorice lozenge and preparation process thereof

A technology of compound licorice and buccal tablets, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc., can solve problems such as the melting process of compound licorice tablets for patients, failure to achieve therapeutic effects, and failure to achieve. Achieve ideal curative effect, good clinical effect and reduce loss

Inactive Publication Date: 2003-08-06
江西制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, compound licorice tablets on the market are prepared according to conventional tablet production methods, which often cause nausea and vomiting when taken orally, and cannot allow most patients to complete the melting process of compound licorice tablets in the oral cavity, and cannot achieve the clinical effect of the drug
The main reason is that the active ingredients camphor and star anise oil in the tablet have a special stench, which makes most users unacceptable or produce nausea, vomiting, etc., thus changing the oral administration ordered by the doctor to swallowing , ultimately no therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Formula 1: Licorice Extract Powder 112.5g Sodium Benzoate 2g

[0021] Opioid Powder 4g Star Anise Oil 2g

[0022] Camphor 2g Micronized silica gel 20g

[0023] Cane Sugar Powder 350g Gum Arabic 10g

[0024] Talc 10g Spice 5g

[0025] A total of 1000 pieces were made

[0026] Preparation:

[0027] (1) dissolving camphor in star anise oil, then adding the star anise oil dissolved in camphor into micropowder silica gel, stirring and mixing evenly, and then placing it for 12 hours to obtain adsorbate powder;

[0028] (2) Mix licorice extract powder, opium powder, sodium benzoate, sucrose powder, and gum arabic, and grind them in a high-efficiency mill so that the mixture can pass through a 120-mesh sieve, then add 90% ethanol solution to make 14-mesh granules , dried at 60°C for 4 hours to obtain dry granules;

[0029] (3) Mix the adsorbate powder with the dried granules, add spices and lubricant talcum p...

Embodiment 2

[0031] Formula 2: Licorice Extract Powder 112.5g Sodium Benzoate 2g

[0032] Opioid Powder 4g Star Anise Oil 2g

[0033] Camphor 2g Activated Carbon 10g

[0034] Lactose 350g Polyvinylpyrrolidone 10g

[0035] Stevioside 10g Magnesium Stearate 5g

[0036] Spice 5g

[0037] A total of 1000 pieces were made

[0038] Preparation:

[0039] (1) dissolving camphor in star anise oil, then adding the star anise oil dissolved in camphor into micropowder silica gel, stirring and mixing evenly, and then placing it for 12 hours to obtain adsorbate powder;

[0040] (2) Mix licorice extract powder, opium powder, sodium benzoate, lactose, polyvinylpyrrolidone, and stevioside, and put it into a high-efficiency mill to grind the mixture so that the mixture can pass through a 120-mesh sieve, and then add 90% ethanol solution to make it The granules are 14 mesh, and dried at 60°C for 4 hours to obtain dry granules;

...

Embodiment 3

[0043] Formula 3: Licorice Extract Powder 112.5g Sodium Benzoate 2g

[0044] Opioid Powder 4g Star Anise Oil 2g

[0045] Camphor 2g Beta-cyclodextrin 25g

[0046] Mannitol 300g Microcrystalline Cellulose 100g

[0047] Pectin 30g Aspartame 10g

[0048] Spice 3g Talc 15g

[0049] A total of 1000 pieces were made

[0050] Preparation:

[0051] (1) Dissolving camphor in star anise oil, then adding β-cyclodextrin, dry milling for 30 minutes (or ball milling for 8 hours), and standing for more than 12 hours to obtain embedded substance powder;

[0052] (2) Take by weighing licorice extract powder 90g (accounting for 80% of the total weight of licorice extract powder), add opium powder, sodium benzoate, mannitol, microcrystalline cellulose, pectin, aspartame, and place in a high-efficiency mill Grind the powder in the powder machine to make the fineness of the mixed powder reach more than 120 mesh, then use 90% eth...

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PUM

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Abstract

The present invention discloses a compound licorice lozenge and its preparation method. Its prescription includes licorice extract powder and powdered opium, etc. and it is characterized by that it also includes off-odor removing agent, filling agent, mucilage and correctives, in which the off-odor removing agent can invest and adsorb the putrid odor produced by camphor and anise star oil, and said lozenge has good taste, has no special putrid odor, and its effective component can be directly acted on the pharyngeal portion, laryox portion and trachea region of oral cavity, so that it can obtain obvious effect for removing the phlegm, relieving cough, relieving inflammation and killing bacteria.

Description

technical field [0001] The invention relates to medicines in the field of medicine, in particular to a compound licorice buccal tablet which can be taken orally and can improve the clinical treatment effect and a preparation method thereof. Background technique [0002] Compound licorice tablet is an oral tablet that has been produced and sold in my country for the treatment of upper respiratory tract infection and acute bronchitis. swallow. [0003] The main ingredients of compound licorice tablet are: licorice extract powder, opium powder, camphor, star anise oil, sodium benzoate. The function of the licorice extract powder in the formula is to cover the inflamed pharyngeal mucosa, protect the surface of the mucosa, and reduce irritation. In addition, it also has the function of promoting the secretion of the throat and bronchi, making it easy to spit out phlegm; the opium powder contains morphine, Its content is 10%, which has the effect of relaxing bronchial smooth musc...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P11/10A61P11/14
Inventor 刘智
Owner 江西制药有限责任公司
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