The invention discloses a medicine for treating the viral hemorrhagic disease of trionyx sinensis. The medicine comprises the following components: radix isatidis, fructus forsythia, flos lonicerae, flos chrysanthemi indici, cordate houttuynia, liquorices, andrographis paniculate, radix paeoniae rubra, blackberry lily, pine needle, sodium chloride, radix astragali, goldthread root, rheum officinale, phellodendron, radix sophorae falvescentis, garlic, rhizoma calami, fructus cnidii, dried tangerine peel, hawthorns, camphor, rhizome of cyrtomium, dandelion, herba epimedii, potassium sulphate, sodium bicarbonate, vitamin C, vitamin E and vitamin K3. The medicine for treating the viral hemorrhagic disease of trionyx sinensis disclosed by the invention restrains virus, can be used for treating the viral hemorrhagic disease of turtles with effective percent of over 95%, and the cure rate in 20 days reaches 90 percent above; and the medicine for treating the viral hemorrhagic disease of trionyx sinensis has reasonable compatibility, can resist fungi as well as remove garlic stink due to the use of dried tangerine peel, hawthorns, cordate houttuynia, flos lonicerae, flos chrysanthemi indici, phellodendron and the like; the preparation method of the medicine for treating the viral hemorrhagic disease of trionyx sinensis can improve the extraction rate of effective ingredients and reduce the loss of useful substances; and firstly mixing garlic with dried tangerine peel can remove the stink of garlic in advance.