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Penicillin V potassium micro-capsule and preparation method thereof

A technology for penicillin V and preparations, applied in the field of penicillin V potassium microcapsules and its preparation, can solve the problems of no antibacterial effect, etc., and achieve the effects of environmental protection, elimination of bad smell, and easy operation and implementation

Inactive Publication Date: 2014-07-02
北京中科锐进科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No antibacterial effect on penicillinase-producing strains

Method used

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  • Penicillin V potassium micro-capsule and preparation method thereof
  • Penicillin V potassium micro-capsule and preparation method thereof
  • Penicillin V potassium micro-capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Grind ethyl cellulose to 80 mesh, penicillin V potassium to 80 mesh, accurately weigh 1 g of penicillin V potassium and 1 g of ethyl cellulose, add ethyl cellulose to 80 mL of dichloromethane under stirring until completely dissolved , to obtain solution a; penicillin V potassium was added to dissolve in solution a under stirring at a rotational speed of 400 rpm to obtain solution b, and solution b was stirred at a rotational speed of 400 rpm for 20 min. Put 800mL of water in a beaker for a water bath, control the temperature of the water bath at 35°C, add 1g of surfactant sodium lauryl sulfate while stirring to obtain solution c, add solution b to solution c, and stir at 400rpm until two The methyl chloride was completely volatilized, the solid product was filtered under reduced pressure, the microcapsules were washed 3 times with distilled water, and dried to obtain 1.76 g of dry solid powder. The particle size range is 50-700 μm, the average particle size is 131.9 μm...

Embodiment 2

[0037] Grind ethyl cellulose to 80 mesh, penicillin V potassium to 80 mesh, accurately weigh 2 g of penicillin V potassium and 1 g of ethyl cellulose, add ethyl cellulose to 80 mL of dichloromethane under stirring until completely dissolved , to obtain solution a; penicillin V potassium was added to dissolve in solution a under stirring at a rotational speed of 400 rpm to obtain solution b, and solution b was stirred at a rotational speed of 400 rpm for 20 min. Put 500mL of water in a beaker for a water bath, control the temperature of the water bath at 35°C, add 1g of surfactant sodium lauryl sulfate while stirring to obtain solution c, add solution b to solution c, and stir at 400rpm to two The methyl chloride was completely volatilized, the solid product was filtered under reduced pressure, the microcapsules were washed 3 times with distilled water, and dried to obtain 1.82 g of dry solid powder.

Embodiment 3

[0039] Ethyl cellulose was crushed to 80 meshes, penicillin V potassium was crushed to 80 meshes, 2 g of penicillin V potassium and 2 g of ethyl cellulose were precisely weighed, and ethyl cellulose was added to 150 mL of dichloromethane under stirring until completely dissolved. Obtain solution a; add penicillin V potassium to the solution a under stirring at a rotation speed of 400 rpm to dissolve to obtain solution b, and stir solution b at a rotation speed of 400 rpm for 20 min. Put 800mL of water in a beaker for a water bath, control the temperature of the water bath at 35°C, add 1g of surfactant sodium lauryl sulfate while stirring to obtain solution c, add solution b to solution c, and stir at 400rpm until two The methyl chloride was completely volatilized, the solid product was filtered under reduced pressure, the microcapsules were washed 3 times with distilled water, and dried to obtain 1.6 g of dry solid powder.

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Abstract

The invention discloses a penicillin V potassium micro-capsule and a preparation method thereof. The penicillin V potassium micro-capsule consists of a core material penicillin V potassium and a capsule wall material ethyecellulose. The preparation method comprises the following steps: 1) smashing and dissolving ethyecellulose in dichloromethane to obtain a solution a; 2) dissolving the smashed penicillin V potassium under stirring at a rotating speed of 100-500rpm in the solution a to obtain a solution b, and continuously stirring for 20-30 minutes; 3) controlling temperature of water and dispersing a surfactant in water to obtain a solution c; and 4) under the condition of stirring at a speed of 100-500rpm, adding the solution b into the solution c to form the penicillin V potassium micro-capsule, continuously stirring till dichloromethane is fully volatilized, filtering under reduced pressure, and washing the micro-capsule three times by using distilled water, and drying to obtain the penicillin V potassium micro-capsule. According to the invention, the micro-capsule is prepared by a drying-in-liquid method to eliminate harmful smell of penicillin V potassium so as to improve the compliance of the patient. The preparation process of the micro-capsule uses easily available and low-price raw materials, is low in production cost, simple in process operation, easy to operate and implement and high in yield.

Description

technical field [0001] The invention relates to a penicillin V potassium microcapsule and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Penicillin V potassium belongs to β-lactam antibiotics, suitable for mild and moderate infections caused by penicillin-sensitive strains, including tonsillitis, pharyngitis, scarlet fever, erysipelas, etc. caused by streptococcus; bronchitis caused by Streptococcus pneumoniae , otitis media, sinusitis; and skin and soft tissue infections caused by penicillin-sensitive staphylococci. Penicillin V potassium can also be used as a preventive drug for recurrent rheumatic fever and infective endocarditis, and can also be used for spirochete infection. Antimicrobial activity against most gram-positive, gram-negative cocci, individual gram-negative bacilli (eg, Haemophilus), spirochetes, and actinomycetes, but most strains of staphylococci (>90%) include S. aureus An...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/43A61K47/38
Inventor 霍清杨晓方
Owner 北京中科锐进科技有限责任公司
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