63 results about "Endocarditis" patented technology

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.

The invention relates to a cefathiamidine hydrate and a preparation method and application thereof. The crystalline hydrate has high storage stability, is suitable for preparing bacteria sensitive to Gram-positive or negative bacteria, and is applied to the preparation of medicaments for treating or preventing infection of respiratory systems, liver and gall bladder systems, five sense organs, urogenital systems, bones, joints and skin soft tissues as well as diseases such as endocarditis, septicemia, brain fever and the like of human beings or animals caused by bacteria which are sensitive to Gram-positive or negative bacteria.

The invention relates to a metagenomic data analysis method and system. The data analysis method and system of the present invention obtains the preliminary species identification result of the sample based on the k-mer algorithm, and based on the preliminary species identification result, extracts part or all of the supporting sequences, uses the blast algorithm to verify the preliminary species identification result, and judges Whether the preliminary species identification result is a reported detected species. The method and system of the present invention can reduce false positives, quickly and accurately obtain the reported species of the sample in a short period of time, and are compatible with a variety of mainstream sequencing platforms, and are suitable for second-generation sequencing technology and third-generation sequencing technology; The method and system of the present invention can also accurately identify and map the drug-resistant genes and drug-resistant mutation sites of samples to report detection species. Furthermore, the system of the present invention can be used to identify pathogenic microorganisms, especially endocarditis pathogens, and overcome the defect that they are difficult to cultivate.

The invention discloses a vascular stent prosthesis for preventing peripheral leakage from a creased skirt edge, a processing method and a skirt edge creasing method. The vascular stent prosthesis comprises a stent and a flexible skirt edge, wherein the skirt edge has a spreading state and a stacking state; in the spreading state, the skirt edge axially extends and encircles the periphery of the stent before release; in the stacking state, the skirt edge is driven under the deformation effect during release of the stent and folded and stacked in the axial direction of the released stent to form an annular circumferential leakage blocking part; the vascular stent prosthesis is also provided with a traction rope which only penetrates through the skirt edge, and the traction rope is linked with the radial deformation when the stent is released so as to drive the skirt edge to switch into the stacking state. According to the vascular stent prosthesis, a peripheral leakage prevention technology is adopted for ensuring that the interventional stent is better matched with the inner wall of a blood vessel, the stent is unlikely to move and more stable, the range of the suitable crowds is enlarged, the additional risk of an operation is reduced, and complications such as peripheral leakage, thrombus and the like are prevented. Better hemodynamic performance is provided, the climbing function of host endothelial cells is improved, the occurrence probability of endocarditis is decreased, and the normal blood supply function of the heart and blood vessels recovers.