The present invention provides terpene-based synthase, a nucleic acid molecule, a construction body, recombinant cells and uses of the terpene-based synthase, the nucleic acid molecule, the construction body and the recombinant cells, and a terpene-based synthase obtaining method. Compared to the wild type terpene-based synthase, the terpene-based synthase of the present invention has at least oneof the following mutations that the aromatic amino acid in the hydrophobic or neutral amino acid in the active region is mutated into the non-aromatic amino acid, and the non-aromatic amino acid in the hydrophobic or neutral amino acid in the active region is mutated into the aromatic amino acid. According to the present invention, under the catalytic effect of the terpene-based synthase of the present invention, the abundance of the main product in the catalytic product can be changed, and the original by-product can be changed into the main product or the new terpene-based compound can be obtained.