The invention discloses a preparation technique for cefpirome sulfate, which is carried out according to the following steps: first, a crude product of the cefpirome sulfate is put into water, or proper alcohol and alkaline solution are added to the cefpirome solution and stirred until pH value is between 3.0 and 6.0 so as to cause solid cefpirome sulfate to be dissolved; meanwhile, a discoloring agent is added, and stirring and discoloring are carried out, wherein, the mole ratio of the dosage of the discoloring agent to the dosage of the cefpirome is between 1 to 500 and 1 to 10; second, active carbon is added, stirred for 20min to 60 min and is filtered; third, sulphuric acid solution is used for adjusting the pH value of filter liquid to be 1.0 to 4.0; acetone is added and crystallization is carried out; fourth, vacuum filtration is carried out; acetone is used for cleaning crystals; the wet crystal is dried, thus obtaining the cefpirome sulfate. The preparation technique for preparing the cefpirome sulfate has high yield, high purity and good crystal form and can obtain the cefpirome sulfate without mixed color.