The invention discloses a method for preparing a spherical organic micro-molecular monomer or compound through an emulsion technology. The method comprises the following steps: adding one or more organic micro-molecules to a solvent-nonsolvent, stirring the one or more organic micro-molecules and the solvent-nonsolvent, adding a surfactant, carrying out ultrasonic or mechanical emulsion after the above obtained emulsion is uniformly dispersed, precipitating crystals through adopting a crystal precipitation technology to obtain a solid and liquid mixture, filtering the mixture, washing the obtained solid, and drying the washed solid to obtain monomer or compound spherical crystals. Compounding, super refinement and spheroidization of the organic micro-molecules are combined in the invention, so the sensitivity of an energetic material is greatly reduced, the fluidity and the loading density of the energetic material are improved, and the viscosity of the crystals in the 3D printing or PBX explosive slurry of the energetic material is reduced; the change of the melting point and the solubility of a medicine improves the stability and the bioavailability of the medicine and facilitates pressing into tablets; and the crystals allow the researching and application fields of conductive organic crystals, nonlinear optical crystals, dyes, photograph raw material pigments and agrochemicals to be expanded.