The invention discloses a detoxifying and acne-removing cream and a preparation method thereof. The detoxifying and acne-removing cream is mainly composed of the following components: white beeswax, stearic acid, ozokerite, lanolin, vaseline, squalane, cyclopolymerized bismuth Methylsiloxane / PEG‑10 Dimethicone, Tocopheryl Acetate, Isooctyl Palmitate, Titanium Dioxide, Color Silica, Guava Leaf Extract and Hexamidine Diisethionate salt composition. The invention can alleviate the symptoms of red and swollen acne within 48 hours, and has better effects of removing acne and reducing inflammation. The invention has strong anti-inflammation, bactericidal, anti-oxidation, cell activating effects, etc., detoxifies and detoxifies, strengthens immunity, and has remarkable curative effect for treating acne, acute eczema and genital eczema. The invention is a pure oil product, which can block the re-invasion of external bacteria, quickly penetrate into the bottom of the skin, is gentle and non-irritating, deeply repairs, removes marks, and makes the skin even, delicate and smooth.