89 results about "Bacteremia" patented technology

This invention provides a treatment regimen that is effective in inhibiting chemotherapy-induced apoptosis and promoting cell survival. The invention also relates to a treatment regimen that confers resistance to caspase activation, thereby inhibiting caspase-mediated, proteolytic cleavage of functional cellular enzymes. Specifically, subjects undergoing chemotherapy are first exposed to a pretreatment regimen. Under this regimen, a GLP-2 receptor activator, such as h[GLY2]-GLP2, is administered each day for a predetermined beneficial period, e.g., three consecutive days. Approximately about 1 week following pretreatment, the subjects are exposed to an appropriate chemotherapy treatment regimen. Pretreatment with a GLP-2 receptor activator followed by administration of chemotherapeutic agents improves cell survival, reduces bacteremia, attenuates epithelial injury, and inhibits cellular apoptosis. Moreover, it does not impair the effectiveness of chemotherapy nor result in weight loss. The anti-apoptotic effects of GLP-2 may be useful in the reduction of cytoxicity and bacterial infection induced by chemotherapeutic agents.

Streptococcus pneumoniae is a major cause of pneumoniae, meningitis, and major cause of morbidity and mortality throughout the world by bacterial otitis media, pneumoniae, meningitis, and bacteraemia. It is an important agent of disease in man especially among infants, the elderly and immunocompromised persons. The present invention provides a solution to this problem by providing a substantially pure or isolated disease related antigen selected from the group consisting of the isolated, recombinant or synthetic S. pneumoniae human immunogenic antigens of SP_0562, SP_0965, SP_0082 (in particular the fragments SP4 and SP 17 of said SP_0082), and a Periplasmic Binding Protein (PBP) (in particular SP_1683 or SP_1386), or a fragments thereof or substantially identical antigen for use in a treatment to induce a immunological memory in a human against S. pneumoniae cells for use in a vaccination treatment of S. pneumoniae disorder in human or against S. pneumoniae in a human. In a particular embodiment, the present invention provides an isolated, recombinant or synthetic S. pneumoniae Periplasmic Binding Protein (PBP) (in particular SP_1683 or SP_1386) as a disease related antigen for use in a treatment to induce a immunological memory in a human against S. pneumoniae cells for use in a vaccination treatment of S. pneumoniae disorder in human or for use in the treatment of an S. pnewnoniae infection in a human. It further provides antibodies that specifically bind to the S. pneumoniae disease related antigens identified herein for use in the treatment of a an S. pneumoniae infection in a human, such as for example in a treatment to induce immunological memory in a human against S. pneumoniae, i.e. in a vaccination treatment of S. pneumoniae. It is also an aspect of the present invention to provide the use of any one of the S. pneumoniae disease related antigens as identified herein, or of the antibodies specific for said antigens in methods to diagnose for a S. pneumoniae disorder in a human.

The present invention provides a method of preventing or treating bacteremia caused by Staphylococcus aureus, comprising administering a monoclonal or polyclonal antibody composition comprising antibodies specific for one or more S. aureus antigens. In one specific embodiment, the composition is a hyperimmune specific IGIV composition. In another specific embodiment, the composition comprise antibodies to a capsular polysaccharide S. aureus antigen, such as the Type 5 and/or Type 8 antigens. In another embodiment, the composition comprises monoclonal antibodies to a capsular polysaccharide S. aureus antigen. This method provides an effective tool for preventing or treating S. aureus bacteremia, and can be used alone or in combination with other therapies.

This invention relates to a method for identifying 28 kinds of common pathogens of clinical bacteremias, which crosslinks 30 types of specific probes against the 28 kinds of common pathogens on 30 kinds of different fluorescent microspheres to be reacted with the being tested specimens then to be reacted with the report molecules labeled by fluorescent elements to test the specific 23SrDNA of them on a fluorescent test device.

The invention relates to a lignin compound that could prevent yellow staphylococcal bacteria and B type hemolytic streptococcus, and the medicine combination of the compound. The invention of lignin Morgan dandehon herb acid A and Rufescidride has obviously effect restraining yellow staphylococcal and B type hemolytic streptococcus. It is also respected to prevent the diseases caused by them, like boil, blain, toxicity epidermis necrolysis, pneumonia, etc.

The invention provides a group ABC meningococcus combined vaccine and a preparing method thereof. The group ABC meningococcus combined vaccine is prepared from a group A and group C meningococcus polysaccharide-protein conjugate, and recombinant protein of a human H factor binding protein (fHBP) subgroup A and a human H factor binding protein (fHBP) subgroup B of group B meningococcus. The invention further provides a preparing method of the recombinant fHBP-A protein and fHBP-B protein. The combined vaccine is used for immunity of children 2 or more years old, and used for preventing invasive diseases such as cerebrospinal meningitis, bacteremia, pneumonia and pericarditis caused by group A or group B or group C meningococcus, and providing a better and wider protection effect on meningococcus.

This invention relates to Ligulatrovine A separated from Ligularia actroviolacea that can prevent and treat diseases related to Staphylococcus aureus and beta hemolytic streptococcus, its pharmaceutical salts and drug composition. Ligulatrovine A has significant inhibitive effect on Gram-positive bacteria, and can prevent and treat diseases such as boil, pustule, pneumonia, osteomyelitis, acute myocarditis, endocarditis, meningitis, mastitis, cystitis, pelvic inflammation, urinary inflammation, prostatitis, bacteremia, or abscess in muscle, skin, urogential region or central nervous system caused by Gram-positive bacteria infection.

A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species.

The invention discloses antibacterial and anti-inflammatory mouthwash and a preparation method thereof. A main effective component of the mouthwash is a traditional Chinese medicinal extract. The Chinese medicinal extract is prepared from the following raw materials in parts by weight: 25 to 30 parts of rose flower, 4 to 8 parts of flower and root of rosa multiflora, 15 to 20 parts of honeysuckle flower, 6 to 12 parts of herba houttuyniae, 8 to 13 parts of fructus forsythia, 3 to 6 parts of all grass of tagetes patula L, 2 to 4 parts of fructus toosendan, 6 to 8 parts of cortex magnoliae officinalis, 10 to 15 parts of Chinese gall, 4 to 6 parts of roughhaired holly root, 6 to 8 parts of rhizoma polygoni cuspidati, 8 to 12 parts of radix bupleuri, 28 to 35 parts of fresh green lemon, 7 to 10 parts of radix paeoniae alba, 8 to 12 parts of eucalyptus globules and 6 to 9 parts of prepared liquorice root. The mouthwash can realize antibacterial and anti-inflammatory effects while teeth are cleaned in a mouth rinsing process; the mouthwash has the efficacy of effectively inhibiting pathogenic bacteria in an oral cavity from breeding, preventing and treating diseases such as pericoronitis of the wisdom tooth, and preventing serious systemic complications caused by oral diseases such as bacteremia and septicemia.

The invention discloses a flavonoid glycoside and medical salt and application to prevent Micrococcus pyogenes and beta hemolytic streptococcus, which is characterized by the following: preventing pustule, toxic epidermal decay, acute myocarditis, cystitis, cervicitis and tumour of neutral nerve system; fitting for treating prostatitis, pneumococcus, medullitis and knuckle disease.

The invention provides a multi-component group B meningococcus vaccine and a preparation method thereof. The multi-component group B meningococcus vaccine disclosed by the invention comprises a groupB meningococcus low-endotoxin mutant outer membrane vesicle (OMV), recombinant lipoproteins (fHbp-A, fHbp-B) of group B meningococcus subfamily A and subfamily B human factor H binding proteins (fHbp), a group B meningococcus neisserial adhesion A (NadA) recombinant protein, and a group B meningococcus neisseria heparin binding antigen (NHBA) recombinant protein. The vaccine disclosed by the invention is used for preventing cerebrospinal meningitis, bacteremia, pneumonia, pericarditis and other invasive diseases caused by the group B meningococcus, and provides wide effective protection effects to the group B meningococcus.

The invention relates to the field of clinical microorganism identification, and provides a kit for rapidly identifying a bacterium in a blood source and a method thereof. The kit comprises: two universal primers amplify the V1 variable region of a bacterium 16S r RNA, one sequencing primer measures the sequence of a V1 forward sector, HRP-avidin labels a magnetic bead, and genus is judged by comparing sequencing results and a database. The kit can sequence and distinguish the bacterium in the blood source at a time, can be used for clinical diagnosis of bacteriaemia and ichorrhemia, not only saves the valuable rescuing time for clinical diagnosis and treatment, and has low cost, convenient operation and strong specificity.

The present invention discloses an application of typhoid and paratyphoid salmonella in the anti-tumor aspect, which is invented to solve the problems of great side effects and poor effects of the prior art in the treatment of tumors. The present invention provides the application of the typhoid and paratyphoid salmonella in the rapid anti-tumor aspect. Wherein, the tumors are one or more of gastric cancer, lung cancer, liver cancer, tongue squamous cancer, breast cancer, colon cancer, leukemia, brain tumor and sarcoma. The invention makes use of the rapid combination of the typhoid and paratyphoid salmonella with the mononuclear cells after entering into the human body, the strong endotoxin and bacteremia are released and the temperature reaches highly around 40 DEG C to 42 DEG C, so as to affect and inhibit the growth and the life cycle of the tumor cells, furthermore, the large mononuclear cells-macrophages in the reticuloendothelial system are proliferated greatly, thus enhancing the ability of the macrophages in vivo to swallow the cancer cells, so the invention has very significant inhibiting and killing effects of a variety of tumors.