31 results about "Cefotetan Disodium" patented technology

This invention provides a method for preparing disodium cefotetan. The method has such advantages as abundant raw material (7-BAMCA), mild reaction conditions, no need for separation and purification of intermediate, and easy operation, thus is suitable for industrialization.

The invention relates to a cefotetan disodium hydrate and a preparation method and application thereof. The cefotetan disodium hydrate has high storage stability, and is applicable to the preparation of medicines for treating or preventing diseases of the human being or animals caused by gram-positive or gram-negative sensitive bacteria, such as respiratory system diseases, hepatobiliary system diseases, five-sense organ diseases, urinary tract infection, celiac infection, pelvic infection, ichorrhemia, skin tissue infection, bone and joint infections, cephalomeningitis and endocarditis.

The invention relates to a cephamycin intermediate compound and a preparation method thereof. The cephamycin intermediate compound has a structure of formula (I), and is prepared by directly reacting 7beta-chloroacetamide-7alpha-methoxy-3-(1-methyl-1H-tetrazole-5-thiomethyl)-3-cephem-4-carboxylic acid and dicyclohexylamine in a specific solvent to form a salt and crystallizing. The cephamycin intermediate compound has the characteristics of high purity, high stability and the like, is conductive to improving the purity of cephamycin final products such as cefminox sodium, cefmetazole sodium and cefotetan disodium, and is beneficial to large-scale production and application.

The invention discloses a preparation method of cefotetan disodium and belongs to the technical field of medicine. The preparation method includes the steps of A, adding methanol to a reactor by stirring and controlling the temperature, and then adding cefotetan disodium and salt-forming agent by stirring until dissolved clarification is achieved to obtain a mixed solution; B, controlling the temperature of the reactor and adding a small amount of organic solvent to the reactor till the system is a bit muddy for primary crystallization; C, after the completion of primary crystallization, adding an organic solvent for secondary crystallization, and performing filtration to obtain cefotetan disodium solid crystal; D, washing the cefotetan disodium solid crystal prior to atomizing drying andvacuum drying to obtain a cefotetan disodium product. The cefotetan disodium is low in the content of purities, good in fluidity, uniform in size distribution, stable in quality, convenient for subsequent sub-packaging of powder and needle preparation products and high in safety of drug use. The preparation method has the advantages of simpleness in operation and energy conservation and environment protection.

The invention discloses a medicinal composition of cefotetan disodium, which comprises the cefotetan disodium, and also comprises minor ingredients; the percentage by mass of the cefotetan disodium is 50 to 99 percent; and the percentage by mass of the minor ingredients is 1 to 50 percent. The medicinal composition of the cefotetan disodium is added with the minor ingredients capable of strengthening the stability of the cefotetan disodium to inhibit the quick degradation of the cefotetan disodium when the cefotetan disodium meets water in the processes of production, storage and use and improve the stability of the cefotetan disodium, so that a high-efficiency and stable medicinal composition product of the cefotetan disodium is obtained.

The invention discloses a novel crystal form of cefotetan acid, a method for preparing cefotetan disodium by the novel crystal form of the cefotetan acid and a pharmaceutical composition containing the cefotetan disodium. The X-ray diffraction pattern of the novel crystal form appears no X-ray diffraction peak; the endothermic peak in the differential thermal analysis pattern is positioned at 158.3 DEG C; the exothermic peak is positioned at 144.6 DEG C. The novel crystal form solves the technical problem of instability of the cefotetan disodium prepared by using the cefotetan acid in the prior art. The used preparation method has good operability and few residues of organic solvent, and is specifically suitable for large-scale industrial production.

The invention relates to a method for removing an impurity, namely delta<2>-isomer from cefotetan disodium. Specifically, the method comprises the following steps of: adding crude cefotetan disodium, copper (I) hydride and tri-n-butyl tin hydride into acetonitrile, stirring uniformly under the protection of nitrogen, reacting under thermal insulation, pouring the obtained product into 5 percent diluted hydrochloric acid, extracting an aqueous phase by using ethyl acetate, mixing ethyl acetate phases, washing the merged ethyl acetate phase by using water, drying by using anhydrous sodium sulfate, filtering, concentrating ethyl acetate under reduced pressure, treating by using sodium bicarbonate, and filtering to obtain the cefotetan disodium. The yield is up to 94 percent.

The invention relates to a preparation method of cefmetazole. The preparation method comprises the steps of adopting a one-pot method containing 7-ACA, 1-methyl-5-tetrazole-thione and chloroacetyl chloride, obtaining 7-DCT, then using seven-position methoxy groups of sodium methylate and tert-butyl hypochlorite, and obtaining methoxy cephalosporin mother nuclei which are shared mother nuclei. The cefmetazole can serve as four methoxy cephalosporin products, namely cefminox, cefmetazole, cephalosporin and cefotetan disodium, three steps are omitted, the processing steps are greatly shortened, cost is lowered, and the overall yield is raised to 70%.