The invention provides a
cefminox sodium preparation method, which comprises: (1) dispersing a compound having a structure represented by a formula (VII) in an
organic solvent A to prepare a solutionor a suspension, adding a compound having a structure represented by a formula (VII), and carrying out
vacuum drying to obtain a compound having a structure represented by a formula (VI); (2) dispersing the compound with the structure represented by the formula (VI) into an
organic solvent C, adding a compound having a structure represented by a formula (V) in a dropwise manner, and
drying to obtain a compound having a structure represented by a formula (IV); (3) dispersing the compound having the structure represented by the formula (IV) in an
organic solvent, and removing the
solvent by rotary
evaporation under a pressure reducing condition to obtain an organic phase containing a compound having a structure represented by a formula (II); and (4) adding
purified water into the solution containing the compound having the structure represented by the formula (II), heating, adjusting the pH value, adding a compound having a structure represented by a formula (III), carrying out
temperature control stirring, transferring the water phase into a crystallizing tank, crystallizing, and carrying out pressure reducing
drying to obtain the
cefminox sodium heptahydrate. According to the invention, the synthesis process is shortened, the cost is reduced, and the product yield and the purity are high.