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Sinomenine hydrochloride slow-release injection and preparation method thereof

A technology of sinomenine hydrochloride and sustained-release injection, which can be used in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., and can solve problems such as large side effects and frequent use.

Active Publication Date: 2011-06-08
HUNAN ZHENGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sinomenine hydrochloride is mainly used as an injection for clinical treatment. Although sinomenine hydrochloride injection has a definite curative effect, it has the disadvantages of frequent use (injection once a day) and large side effects in clinical practice.

Method used

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  • Sinomenine hydrochloride slow-release injection and preparation method thereof
  • Sinomenine hydrochloride slow-release injection and preparation method thereof
  • Sinomenine hydrochloride slow-release injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Dissolve 10Kg of sinomenine hydrochloride in 0.2KL of water as the internal water phase, and dissolve 100Kg of lactide-glycolide copolymer 50 / 50 or lactide-glycolide copolymer 75 / 25 in 5KL of ethyl acetate as the organic phase, add the inner water phase to the outer water phase, and form water / oil type colostrum by high-speed shearing; add the formed colostrum drop by drop into 20KL aqueous solution containing 1% polyvinyl alcohol, and form water / oil type by high-speed shearing / water-type double emulsion; add this double emulsion to 100KL0.1% polyvinyl alcohol aqueous solution, stir magnetically at room temperature for 20 minutes, evaporate under reduced pressure to remove the organic solvent, centrifuge, wash with water, and dry to obtain synthetic polymer nanoparticles .

Embodiment 2

[0063] Dissolve 15Kg of sinomenine hydrochloride in 0.1KL of water as the internal water phase, and dissolve 140Kg of lactide-glycolide copolymer 50 / 50 or lactide-glycolide copolymer 75 / 25 in 4KL of ethyl acetate as the organic phase, add the inner water phase to the outer water phase, and form water / oil type colostrum by high-speed shearing; add the formed colostrum drop by drop into 30KL aqueous solution containing 0.5% polyvinyl alcohol, and form water / oil type by high-speed shearing / water-type double emulsion; add this double emulsion to 140KL0.08% polyvinyl alcohol aqueous solution, stir magnetically at room temperature for 25 minutes, evaporate under reduced pressure to remove the organic solvent, centrifuge, wash with water, and dry to obtain synthetic polymer nanoparticles .

Embodiment 3

[0065] Dissolve 8Kg of sinomenine hydrochloride in 0.3KL of water as the internal water phase, and dissolve 90Kg of lactide-glycolide copolymer 50 / 50 or lactide-glycolide copolymer 75 / 25 in 7KL of ethyl acetate as the organic phase, add the inner water phase to the outer water phase, and form water / oil type colostrum by high-speed shearing; add the formed colostrum drop by drop to 10KL aqueous solution containing 1.5% polyvinyl alcohol, and form water / oil type by high-speed shearing / water-type double emulsion; add this double emulsion to 90KL0.15% polyvinyl alcohol aqueous solution, stir magnetically at room temperature for 15 minutes, then evaporate under reduced pressure to remove the organic solvent, centrifuge, wash with water, and dry to obtain synthetic polymer nanoparticles .

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Abstract

The invention discloses a sinomenine hydrochloride slow-release injection and a preparation method thereof. The slow-release injection comprises one of a synthetic high molecular polymer nanoparticle sinomenine hydrochloride slow-release injection, a natural high molecular material microsphere sinomenine hydrochloride slow-release injection, a liposome sinomenine hydrochloride slow-release injection, a multi-vesicle liposome sinomenine hydrochloride slow-release injection and a gel sinomenine hydrochloride slow-release injection. In the invention, various sinomenine hydrochloride slow-release injections prepared by different methods can prolong drug action time, reduce medication frequencies, maintain relatively stable in-vivo blood concentration and reduce toxic side effects of drugs.

Description

[0001] The patent application of the present invention is a divisional application, the original application number is 200710175540.3, the application date is September 30, 2007, and the invention name is sinomenine hydrochloride sustained-release injection and its preparation method. technical field [0002] The invention relates to a new pharmaceutical dosage form of sinomenine hydrochloride, in particular to a sinomenine hydrochloride sustained-release injection and a preparation method thereof. Background technique [0003] Sinomenine is an active ingredient extracted from the traditional Chinese medicine Qingfengteng. It is an effective Chinese medicine for treating rheumatism and rheumatoid arthritis. Its hydrochloride is often used in medicine. This variety has remarkable curative effect and good market promotion, and has now become a commonly used drug. At present, sinomenine hydrochloride is mainly used as an injection for clinical treatment. Although sinomenine hyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/485A61K31/473A61K47/42A61P19/02A61P19/04A61P29/00
Inventor 奉建芳吴飞驰邹凌燕仇萍滕健
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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