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Long-acting compound tildipirosin injection and preparation method thereof

A technology of Tedirosin and injection, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of aggravated pain and stress response, and multiple stress responses of sick animals. Stimulate, eliminate short half-life and other problems, achieve the effect of improving clinical symptoms, delaying bacterial drug resistance, and safe antibacterial process

Active Publication Date: 2020-09-01
SOUTH CHINA AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, Tediroxin injections on the market are all single preparations. In the clinical treatment of respiratory infection diseases such as pigs and cattle, it is necessary to inject too much volume of the drug, which is highly irritating and aggravates its pain and stress response; Although flunixin meglumine is absorbed quickly, it is excreted quickly and has a short elimination half-life. Frequent medication increases labor intensity and causes multiple stresses to sick animals.

Method used

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  • Long-acting compound tildipirosin injection and preparation method thereof
  • Long-acting compound tildipirosin injection and preparation method thereof
  • Long-acting compound tildipirosin injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Raw materials: Tedirosin 4g, polyvinylpyrrolidone K10 3g, poloxamer 237 15g, flunixin meglumine 3g, sinomenine 0.02g, β-cyclodextrin 10g.

[0041] Dissolve flunixin meglumine and sinomenine in 10ml of 70% ethanol aqueous solution, add β-cyclodextrin into 2L of 70% ethanol solution, mix the two solutions, and stir at 50°C for reaction 4-6 Hours, until the inclusion reaction is complete, spray-dry to obtain the cyclodextrin inclusion compound of flunixin meglumine and sinomenine.

[0042] Mix polyvinylpyrrolidone K10, poloxamer 237, and 50ml of propylene glycol until dissolved, then add tedirocin and stir for 15min at a speed of 60r / min to obtain solution A. Mix 15ml of polyethylene glycol 300, 15ml of glycerol formal, flunixin meglumine and cyclodextrin inclusion compound of sinomenine and stir at 55r / min for 15min to obtain solution B. After mixing solution A and solution B, dilute to 100ml with propylene glycol, filter with a 0.22μm filter membrane, and inspect the se...

Embodiment 2

[0044] Raw materials: Tedirosin 9g, polyvinylpyrrolidone K15 5g, poloxamer 338 10g, flunixin meglumine 5g, sinomenine 0.1g, β-cyclodextrin 15g.

[0045] Dissolve flunixin meglumine and sinomenine in 10ml of 70% ethanol aqueous solution, add β-cyclodextrin into 2L of 70% ethanol solution, mix the two solutions, and stir at 50°C for reaction 4-6 Hours, until the inclusion reaction is complete, spray-dry to obtain the cyclodextrin inclusion compound of flunixin meglumine and sinomenine.

[0046] Mix polyvinylpyrrolidone K15, poloxamer 338, and 60ml of propylene glycol until dissolved, then add tedirosin and stir for 20min at a speed of 65r / min to obtain solution A. Mix 10ml of polyethylene glycol 300, 10ml of glycerol formal, flunixin meglumine and cyclodextrin inclusion compound of sinomenine and stir at 60r / min for 20min to obtain solution B. After mixing solution A and solution B, dilute to 100ml with propylene glycol, filter through a 0.22μm filter membrane, and inspect the ...

Embodiment 3

[0048] Raw materials: Tedirosin 6g, polyvinylpyrrolidone K30 4g, poloxamer 407 5g, flunixin meglumine 4g, sinomenine 0.2g, hydroxypropyl-β-cyclodextrin 30g.

[0049] Dissolve flunixin meglumine and sinomenine in 10ml of 70% ethanol aqueous solution, add hydroxypropyl-β-cyclodextrin to 2L of 70% ethanol solution, mix the two solutions, and stir at 50°C React for 4-6 hours until the inclusion reaction is complete, and spray dry to obtain the cyclodextrin inclusion compound of flunixin meglumine and sinomenine.

[0050] Mix polyvinylpyrrolidone K30, poloxamer 407, and 70ml of propylene glycol until dissolved, then add tedirosin and stir for 25min at a speed of 70r / min to obtain solution A. Mix 10ml of polyethylene glycol 600, 10ml of glycerol formal, flunixin meglumine, and sinomenine clathrate and stir at a speed of 65r / min for 20min to obtain solution B. After mixing solution A and solution B, dilute to 100ml with propylene glycol, filter through a 0.22μm filter membrane, and ...

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Abstract

The invention discloses a long-acting compound tildipirosin injection and a preparation method thereof. The long-acting compound tildipirosin injection comprises the following main components: tildipirosin, flunixin meglumine and sinomenine. The invention provides a long-acting compound injection special for animals for veterinary clinic, wherein the injection not only can be used for treating respiratory system infectious diseases caused by sensitive bacteria, but also can help to treat or reduce the stress of sick animals; and combination of drugs can significantly improve the clinical symptoms, and can enhance the activity of antibacterial drugs, reduce the use amount of drugs, reduce the administration frequency, reduce animal stress, enhance animal compliance and reduce labor intensity, and the injection is convenient to use.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a long-acting compound tediroxin injection and a preparation method thereof. Background technique [0002] In recent years, with the high intensification of the breeding industry, respiratory infections in pigs and cattle caused by sensitive bacteria such as Actinobacillus pleuropneumoniae, Haemophilus parasuis, Pasteurella multocida and Mannheimia hemolyticus The disease is becoming more and more serious. In most cases, it is clinically accompanied by inflammatory symptoms such as fever and pain, which seriously affects the health of animals and causes serious economic losses. Therefore, a long-acting compound injection that can not only target pathogenic bacteria, but also assist in reducing the stress of sick animals was developed to meet the current veterinary clinical drug needs and ensure and promote the healthy development of the breeding industry. [0003] Tedirosin, a...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61K31/485A61K31/44A61K9/08A61K47/69A61K47/10A61K47/32A61P31/04A61P11/00
CPCA61K9/0019A61K9/08A61K31/44A61K31/485A61K31/706A61K47/10A61K47/32A61K47/6951A61P11/00A61P31/04A61K2300/00
Inventor 方炳虎谢孟娟张桂君梁劲康
Owner SOUTH CHINA AGRI UNIV
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