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Veterinary compound enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, applied in the field of compound enrofloxacin injection for veterinary use, can solve the problems of small application range and poor antibacterial performance, and achieve the effects of broadening the antibacterial spectrum, maintaining stability and good absorption

Inactive Publication Date: 2010-12-29
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no flunixin meglumine is used in the composition, which is mainly suitable for infectious diseases of pigs, and has disadvantages such as small scope of application and poor antibacterial performance

Method used

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  • Veterinary compound enrofloxacin injection and preparation method thereof
  • Veterinary compound enrofloxacin injection and preparation method thereof
  • Veterinary compound enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:

[0036]Enrofloxacin 10g, Sulfamethoxazole 10g, Trimethoprim 5g, Flunixin Meglumine 0.5g, Tylosin 10g, Benzyl Alcohol 10g, Ethanol 20g, N, N Dimethylformamide 10g, α-pyrrolidone 20g, water for injection 4.5g;

[0037] The veterinary compound enrofloxacin injection is prepared by the following steps:

[0038] 1) Mix and dissolve 10 g of enrofloxacin with 10 g of benzyl alcohol to obtain 20 g of enrofloxacin solution;

[0039] 2) Mix and dissolve 10 g of sulfamethoxazole, 5 g of trimethoprim, 0.5 g of flunixin meglumine, 10 g of N, N-dimethylformamide, and 20 g of α-pyrrolidone to obtain sulfamethoxazole, methoxy 45.5 g of mixed solution of benzidine and flunixin meglumine;

[0040] 3) Dissolve 10 g of tylosin in 20 g of ethanol to obtain 30 g of tylosin solution;

[0041] 4) 20 g of enrofloxacin solution prepared in step 1) and 45.5 g of the mixed solution ...

Embodiment 2

[0044] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:

[0045] Enrofloxacin 6g, Sulfamethoxazole 12g, Trimethoprim 4g, Flunixin Meglumine 0.3g, Tylosin 8g, Benzyl Alcohol 15g, Ethanol 15g, N, N Dimethylformamide 20g, α-pyrrolidone 15g, water for injection 5g;

[0046] The preparation steps were the same as in Example 1 to obtain compound enrofloxacin injection for veterinary use, with a pH of 9.5.

Embodiment 3

[0048] A compound enrofloxacin injection for veterinary use contains the following components, all in parts by weight:

[0049] Enrofloxacin 13g, Sulfamethoxazole 6g, Trimethoprim 8g, Flunixin Meglumine 0.5g, Tylosin 5g, Benzyl Alcohol 20g, Ethanol 10g, N,N Dimethylformamide 15g, α-pyrrolidone 20g, water for injection 3g;

[0050] The preparation steps were the same as in Example 1 to obtain compound enrofloxacin injection for veterinary use, with a pH of 9.7.

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PUM

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Abstract

The invention relates to a veterinary compound enrofloxacin injection and a preparation method thereof. The veterinary compound enrofloxacin injection mainly comprises enrofloxacin, sulfamethoxazole, trimethoprim, flunixin meglumine, tylosin, organic solvent and water for injection. The veterinary compound enrofloxacin injection is used as a veterinary special compound preparation, used for treating various infectious diseases of a respiratory system, a digestive system and a skin soft tissue caused by livestock and poultry bacterial and mycoplasma infection, particularly has special effects on secondary hemophilus disease of pigs and poultries caused by hemophilus and has the advantages of convenient use, short course, low drug resistance and the like.

Description

technical field [0001] The invention relates to a veterinary compound enrofloxacin injection, especially a compound made of enrofloxacin, sulfamethoxazole, trimethoprim, fluninew meglumine and tylosin Formulations and methods for their preparation. Background technique [0002] Enrofloxacin, a representative of the new generation of quinolones, is designated as a special drug for animals. It has a significant effect on various infections caused by a variety of bacteria, and its lethality against various mycoplasma is significantly higher than that of Other quinolone drugs and various drugs such as tylosin and tiomycin, which have been used for many years, have broad spectrum, high efficiency, low toxicity, good absorption and convenient administration. The MIC against most strains is lower than 1 μg / ml, and it has obvious post-antibacterial effect (PAE) on sensitive bacteria. It is suitable for various infectious diseases of digestive system, respiratory system, urinary sy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/635A61K31/505A61K31/496A61K31/44A61K9/08A61P31/04A61P11/00A61P1/00A61P17/00A61P29/00
Inventor 陈建波
Owner 陈建波
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