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Compound long-acting injection containing enrofloxacin and flunixin and preparation method of compound long-acting injection

A technology of enrofloxacin and flunixin, which is applied in the field of compound long-acting injection and its preparation, can solve the problems of not exceeding 40°C, the injection is not subjected to terminal sterilization, and animal stress, etc., and can promote the prognosis and prognosis, enhancing animal compliance, improving outcomes and prognosis

Active Publication Date: 2019-10-15
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the enrofloxacin oil suspension injection needs to be carried out under sterile conditions, and the material temperature cannot exceed 40°C during grinding
The preparation process requires high production conditions, which restricts the promotion of industrialization, and the injection is not terminally sterilized, so it is difficult to effectively ensure sterility and endanger animal safety
Chinese patent CN 102697784 A discloses a veterinary enrofloxacin injection and its preparation method, which involves a compound injection containing enrofloxacin and flunixin meglumine, but the injection is an aqueous solution, and the recommended usage is Twice a day, continuous use for 2 to 3 days, requires multiple administrations, time-consuming and laborious, and it is easy to cause animal stress and affect the efficacy of the drug
Chinese patent CN 105213402 A discloses a soluble powder of livestock and poultry compound enrofloxacin and meloxicam, but drinking water is required for administration, and it is suitable for intensively farmed poultry, but there is a lot of waste of drinking water for pigs, dogs, cats, etc. , cattle, sheep, horses, etc. are inconvenient to use based on individual administration, and also require multiple administrations, which is time-consuming and laborious and is not conducive to the efficacy of the drug.

Method used

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  • Compound long-acting injection containing enrofloxacin and flunixin and preparation method of compound long-acting injection
  • Compound long-acting injection containing enrofloxacin and flunixin and preparation method of compound long-acting injection
  • Compound long-acting injection containing enrofloxacin and flunixin and preparation method of compound long-acting injection

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Experimental program
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specific Embodiment approach

[0035] Enrofloxacin or its salts are ultrafinely pulverized, and 90% of the particles have a particle size of ≤15 μm, and particles above 50 μm cannot be detected.

[0036] Flunixin and flunixin meglumine in dispersed form are ultrafinely pulverized, and 90% of the particles have a particle size of ≤5 μm, and no particles larger than 25 μm can be detected.

[0037] The ultrafine pulverization process of enrofloxacin or its salt, flunixin and flunixin meglumine: a fluidized bed supersonic airflow ultrafine pulverization classification system is adopted, and the amount of material entering is controlled at 60-80g. The materials collide with each other at the speed of Mach 2.5 in the crushing chamber, and are crushed quickly. The crushed particles rise to the classification chamber with the airflow, and the qualified particles enter the cyclone separator with the airflow, and finally obtain the desired product, and the tail gas enters the dust collector to be discharged. Under t...

Embodiment 1

[0040] prescription

[0041]

[0042]

[0043] Preparation method: take an appropriate amount of ethyl oleate, heat it to 150-180°C, and continue for 1 hour; take 700mL of heated ethyl oleate and cool it down to 120-140°C, add aluminum monostearate and hydrogenated castor oil, and keep 1-2h to completely gel the aluminum monostearate and hydrogenated castor oil; then let cool to 40-60°C, add microcrystalline wax, Tween 80, Span 60, lecithin, enrofloxacin, enrolactate Flunixin, flunixin inclusion compound and flunixin, stir evenly, and dilute to 1000mL with ethyl oleate cooled to room temperature after heat treatment; test the particle size and content; subpackage after passing the test, and sterilize at 115°C for 30 minutes , the compound long-acting injection containing enrofloxacin injection and flunixin was obtained, and its in vitro performance evaluation was carried out, including the determination of properties, particle size, 3h sedimentation volume ratio, redispe...

Embodiment 2

[0050] prescription

[0051]

[0052]

[0053] Preparation method: Take an appropriate amount of medium-chain fatty acid, heat it to 150-180°C, and keep it for 1 hour; take 600mL of medium-chain fatty acid after heat treatment, cool it down to 120-140°C, add aluminum monostearate and hydrogenated castor oil, and keep it for 1 hour -2h, make it completely gelled; let cool to 40-60°C, add polyvinyl alcohol, Tween 80, Span 85, hydroxylated lecithin, enrofloxacin, flunixin meglumine inclusion compound, Stir well and evenly, use the medium-chain fatty acid cooled to room temperature after heat treatment to make up to 1000mL; test the particle size and content; subpackage after passing the test, and sterilize at 115°C for 30 minutes to obtain the compound containing enrofloxacin and flunixin For long-acting injections, the in vitro performance evaluation was carried out, including the determination of properties, particle size, 3h sedimentation volume ratio, redispersibility, ...

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Abstract

The invention discloses a compound long-acting injection containing enrofloxacin and flunixin. Each 1000mL of the injection is prepared from 50-300g of enrofloxacin or / and a salt thereof, 0-200g of flunixin or flunixin meglumine in a dispersed form, 0-150g of flunixin or flunixin meglumine inclusion compound, 5-20g of a suspending agent, 5-15g of a wetting agent and the balance of dispersion medium, and the flunixin and / or flunixin meglumine in the dispersed form, flunixin and / or flunixin meglumine inclusion compound cannot be zero at the same time. The injection can be used only for one injection, can address both symptoms and root causes, improves the compliance of animals, reduces the stress of the animals, and promotes and improves the outcome and prognosis of diseases. After long-termplacement, drug particles can be evenly dispersed; the injection does not need to be operated under aseptic conditions and can be sterilized only by sterilizing at 115 DEG C for 30 minutes after dispensing, indexes of the injection before and after sterilization are in compliance with the regulations, and the injection is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to a compound long-acting injection containing enrofloxacin and flunixin and a preparation method thereof. Background technique [0002] Enrofloxacin is very slightly soluble in acetone, almost insoluble in water, and its hydrochloride, sodium salt and lactate are easily soluble in water. Enrofloxacin is a special-purpose fluoroquinolone for animals. It is the most commonly used in veterinary clinics. It has special effects on mycoplasma and is stronger than tylosin and colistin. Good; strong against Gram-negative bacteria; good against Staphylococcus aureus, Actinomyces pyogenes, Erysipelas, Chlamydia, etc.; weak against Pseudomonas aeruginosa and Streptococcus; against anaerobic bacteria The effect is weak. Enrofloxacin has obvious post-antibacterial effect on sensitive bacteria, and the antibacterial activity is concentration-dependent. [0003] Since its l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K47/69A61K47/44A61K47/24A61K47/26A61K47/10A61K31/496A61K31/44A61P31/04A61P29/00
CPCA61K9/10A61K9/0019A61K47/6951A61K47/44A61K47/24A61K47/26A61K47/10A61K31/496A61K31/44A61P31/04A61P29/00A61K2300/00Y02A50/30
Inventor 余祖功郭凡溪苗晋锋
Owner NANJING AGRICULTURAL UNIVERSITY
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