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Method for preparing veterinary oxytetracycline-artemisinin injection and clinical application of veterinary oxytetracycline-artemisinin injection

An injection and compound technology, which is applied in the field of preparation of veterinary Tuqing injection, achieves the effect of small dose, significant effect and strong drug effect

Inactive Publication Date: 2011-11-02
SHANDONG DEZHOU SHENNIU ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of the injection are oxytetracycline and trimethoprim, and the efficacy of the product has reached or exceeded that of similar imported products - oxytetracycline injection, but without artemisinin and flunixin meglumine, etc. special effects ingredients

Method used

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  • Method for preparing veterinary oxytetracycline-artemisinin injection and clinical application of veterinary oxytetracycline-artemisinin injection
  • Method for preparing veterinary oxytetracycline-artemisinin injection and clinical application of veterinary oxytetracycline-artemisinin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, preparation method of compound Tuqing injection

[0031] A kind of veterinary compound Tuqing injection, which contains the following components, all in parts by weight:

[0032] Oxytetracycline 10g, artemisinin 4g, trimethoprim 4g, flunixin meglumine 4g, magnesium chloride 4g, sodium thiosulfate 0.5g, ethanolamine 6g, α-pyrrolidone 30g, N,N-dimethyl Formamide 10g, propylene glycol 10g, ethanol 10g, water for injection 8g.

[0033] The Veterinary Compound Tuqing Injection is prepared by the following method:

[0034] (1) Take 30 g of α-pyrrolidone and 10 g of N,N-dimethylformamide in a container, stir evenly, add 10 g of oxytetracycline and stir evenly to obtain liquid A.

[0035](2) Dissolve 4 g of magnesium chloride and 0.5 g of sodium thiosulfate in water, stir and dissolve evenly to obtain liquid B.

[0036] (3) 4 g of trimethoprim was heated with 10 g of propylene glycol at 85° C. to dissolve evenly, and the temperature was lowered to below 30° C. ...

Embodiment 2

[0042] Embodiment 2, preparation method of compound Tuqing injection

[0043] A kind of veterinary compound Tuqing injection, which contains the following components, all in parts by weight:

[0044] Oxytetracycline 15g, Artemisinin 6g, Trimethoprim 5g, Flunixin Meglumine 4g, Magnesium Oxide 6g, Thiourea 0.7g, Ethanolamine 5g, α-Pyrrolidone 25g, N,N-Dimethylformazol Amide 5g, propylene glycol 10g, ethanol 10g, water for injection 9g.

[0045] The Veterinary Compound Tuqing Injection is prepared by the following method:

[0046] (1) Take 15 g of α-pyrrolidone and 5 g of N,N-dimethylformamide in a container, stir evenly, add 15 g of oxytetracycline and stir evenly to obtain liquid A.

[0047] (2) Dissolve 6 g of magnesium oxide and 0.7 g of thiourea in water, stir and dissolve evenly to obtain liquid B.

[0048] (3) 5 g of trimethoprim was heated with 10 g of propylene glycol at 85° C. to dissolve evenly, and the temperature was lowered to below 30° C. to obtain liquid C.

...

Embodiment 3

[0054] Embodiment 3, preparation method of compound Tuqing injection

[0055] A kind of veterinary compound Tuqing injection, which contains the following components, all in parts by weight:

[0056] Oxytetracycline 30g, artemisinin 3g, trimethoprim 3g, flunixin meglumine 2g, magnesium oxide 4g, formaldehyde sodium bisulfite 0.3g, diethanolamine 5g, α-pyrrolidone 15g, N, N-dimethylformamide 10g, propylene glycol 15g, ethanol 7g, water for injection 6g.

[0057] The Veterinary Compound Tuqing Injection is prepared by the following method:

[0058] (1) Take 15 g of α-pyrrolidone and 10 g of N,N-dimethylformamide in a container, stir evenly, add 30 g of oxytetracycline and stir evenly to obtain liquid A.

[0059] (2) Dissolve 4 g of magnesium oxide and 0.3 g of sodium formaldehyde sulfoxylate in water, stir and dissolve evenly to obtain liquid B.

[0060] (3) 3 g of trimethoprim was heated with 15 g of propylene glycol at 85° C. to dissolve evenly, and the temperature was lowe...

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Abstract

The invention relates to a method for preparing a veterinary oxytetracycline-artemisinin injection and clinical application of the veterinary oxytetracycline-artemisinin injection. Raw materials of the injection mainly comprise oxytetracycline, artemisinin, trimethoprim, flunixin meglumine, magnesium oxide or magnesium chloride, an antioxidant, a pH regulator, a compound organic solvent and water. As a veterinary compound preparation, the veterinary oxytetracycline-artemisinin injection is mainly used for treating infectious diseases and secondary infection which are caused by sensitive gram positive bacteria and negative bacteria, eperythrozoon, rickettsia and mycoplasma. The method for preparing the veterinary compound oxytetracycline-artemisinin injection is simple, the production process is mild, the chelating temperature is low, the stability is high, and the injection is convenient to use and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a preparation method and clinical application of tuqing injection for veterinary use, in particular to a preparation method composed of oxytetracycline, artemisinin, trimethoprim, flunixin meglumine and magnesium chloride (or magnesium oxide). The preparation method of the compound preparation. The injection of the invention has significant curative effect on infectious diseases caused by swine asthma, Haemophilus parasuis, enteritis, diarrhea, pasteurella bovine, Eperythroplasma, rickettsia and mycoplasma. Background technique [0002] Oxytetracycline is a tetracycline antibiotic. This product is a broad-spectrum antibacterial agent. Many Rickettsia, Mycoplasma, Chlamydia, Spirochetes, Amoeba and some Plasmodium are sensitive to this product. Others such as Actinomyces, Bacillus anthracis, mononuclear Listeria, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are also sensitive to this product. Oxytetr...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K31/366A61K31/505A61K31/44A61K33/06A61K33/08A61K9/08A61P11/06A61P11/00A61P29/00A61P31/04A61P1/12A61P1/00A61P33/02
CPCY02A40/70
Inventor 郭丽华李逐波刘在青肖建森李莎田洪强陈冰
Owner SHANDONG DEZHOU SHENNIU ANIMAL HEALTH PROD CO LTD
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