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Compound terramycin injection and preparation method thereof

A technology for oxytetracycline and injection, which is applied in the field of preparation of compound oxytetracycline injection and compound oxytetracycline injection, can solve the problems of easy discoloration, precipitation, and reduced titer, and achieves enhanced activity and improved stability. , to avoid wasteful effects

Inactive Publication Date: 2014-11-26
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a compound oxytetracycline injection, which solves the problem that the existing oxytetracycline injection is easy to change color or precipitate when heated or stored for a long time, resulting in a decrease in potency

Method used

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  • Compound terramycin injection and preparation method thereof
  • Compound terramycin injection and preparation method thereof
  • Compound terramycin injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] The compound oxytetracycline injection of the present embodiment is made up of the following raw materials in parts by weight: 20 parts of oxytetracycline, 2 parts of flunixin meglumine, 40 parts of propylene glycol, 10 parts of dimethylformamide, polyvinylpyrrolidone 3 parts of K30, 6 parts of magnesium oxide, 0.5 parts of sodium formaldehyde sulfoxylate, 6.5 parts of ethanolamine, and 28 parts of water for injection.

[0020] The preparation method of the compound oxytetracycline injection of the present embodiment may further comprise the steps:

[0021] 1) Add 0.5 parts by weight of sodium formaldehyde sulfoxylate into 20 parts by weight of water for injection and stir to dissolve to obtain mixture A;

[0022] 2) Add 40 parts by weight of propylene glycol and 10 parts by weight of dimethylformamide to mixture A, stir well, add 3 parts by weight of polyvinylpyrrolidone and stir to dissolve, then add 20 parts by weight of oxytetracycline and 2 parts by weight The flu...

Embodiment 2

[0025] The compound oxytetracycline injection of the present embodiment is made up of the following raw materials in parts by weight: 20 parts of oxytetracycline, 2 parts of flunixin meglumine, 35 parts of propylene glycol, 15 parts of dimethylformamide, polyvinylpyrrolidone 3 parts of K30, 6.5 parts of magnesium oxide, 0.5 parts of sodium formaldehyde sulfoxylate, 6.3 parts of ethanolamine, and 28 parts of water for injection.

[0026] The preparation method of the compound oxytetracycline injection of the present embodiment may further comprise the steps:

[0027] 1) Add 0.5 parts by weight of sodium formaldehyde sulfoxylate into 20 parts by weight of water for injection and stir to dissolve to obtain mixture A;

[0028] 2) Add 35 parts by weight of propylene glycol and 15 parts by weight of dimethylformamide to mixture A, stir well, add 3 parts by weight of polyvinylpyrrolidone and stir to dissolve, then add 20 parts by weight of oxytetracycline and 2 parts by weight The f...

Embodiment 3

[0031] The compound oxytetracycline injection of the present embodiment is made up of the following raw materials in parts by weight: 20 parts of oxytetracycline, 2 parts of flunixin meglumine, 30 parts of propylene glycol, 12 parts of dimethylformamide, polyvinylpyrrolidone 3 parts of K30, 7 parts of magnesium oxide, 0.5 parts of sodium formaldehyde sulfoxylate, 6.1 parts of ethanolamine, and 28 parts of water for injection.

[0032] The preparation method of the compound oxytetracycline injection of the present embodiment may further comprise the steps:

[0033] 1) Add 0.5 parts by weight of sodium formaldehyde sulfoxylate into 20 parts by weight of water for injection and stir to dissolve to obtain mixture A;

[0034] 2) Add 30 parts by weight of propylene glycol and 12 parts by weight of dimethylformamide to mixture A, stir well, add 3 parts by weight of polyvinylpyrrolidone and stir to dissolve, then add 20 parts by weight of oxytetracycline and 2 parts by weight The flu...

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Abstract

The invention discloses a compound terramycin injection and a preparation method thereof. The compound terramycin injection comprises, by weight, 20 parts of terramycin, 2 parts of flunixin meglumine, 30-40 parts of propylene glycol, 10-15 parts of dimethyl formamide, 3 parts of polyvinylpyrrolidone, 6-7 parts of magnesium oxide, 0.5 parts of an anti-oxidant, 6.1-6.5 parts of ethanolamine and 28 parts of injection water. The compound terramycin injection can be used for treating therapy-sensitive infectious diseases caused by gram-positive bacteria and gram-negative bacteria, rickettsia and mycoplasma and has good treatment effects. The compound terramycin injection has good stability, does not discolor after being heated or stored for a long time, does not product precipitates, solves the problem that under the acid or alkaline conditions, the existing terramycin injection discolors or precipitates after being heated or stored for a long time so that titer is reduced, and can slowly release drug active components in the human body so that long-acting effects are obtained.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, in particular to a compound oxytetracycline injection, and also relates to a preparation method of the compound oxytetracycline injection. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic, which has a good inhibitory effect on Gram-positive bacteria and Gram-negative bacteria, and also has certain inhibitory effects on Chlamydia, Rickettsia, Mycoplasma, Spirochetes, etc. Oxytetracycline is mainly used to prevent and control livestock and poultry Escherichia coli, Salmonella infection (such as calf pullorum, lamb dysentery, piglet yellow and white scour, young animal paratyphoid, etc.), Pasteurella, Brucellosis infection and swine panting disease, chicken chronic respiratory disease It is also commonly used to treat rickettsial disease in dogs, infectious anemia in cats, and prevent chlamydial disease and spirochetal disease in dogs; it is also used locally...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K9/08A61P31/04A61P29/00A61K31/44
CPCY02A50/30
Inventor 董晓盈李建正吴红云
Owner ZHENGZHOU HOUYI PHARMA
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