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35 results about "Pyrimethamine" patented technology
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This medication is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection.
Preparation method and application of double-sided loaded pyrimethamine molecularly imprinted compound membrane based on click chemistry
ActiveCN109772178AEasy to separateSolve difficult to recycleSemi-permeable membranesOther chemical processesFunctional monomerFiltration
The invention belongs to the technical field of functional material preparation and discloses a preparation method and application of a double-sided loaded pyrimethamine molecularly imprinted compoundmembrane based on click chemistry. The preparation method comprises the following step of preparing the double-sided loaded pyrimethamine molecularly imprinted compound membrane by combining a double-sided suction filtration loading means based on a click chemistry polymerization method by taking dopamine as a bionic modified material, a carbon nanotube as a membrane loading material, pyrimethamine as a template molecule, methylacrylic acid as a functional monomer, tetra(3-thiohydracrylic acid) pentaerythritol ester as a crosslinking agent and dipentaerythritol pentenoic acid-hexenic acid-acrylic acid as a co-crosslinking agent. The prepared double-sided loaded pyrimethamine molecularly imprinted compound membrane overcomes the defects that an existing pyrimethamine molecularly imprintedcompound membrane is hard to recover, easy to generate secondary pollution and the like effectively. In addition, the pyrimethamine molecularly imprinted compound membrane has good specific recognition ability and adsorption separation ability to pyrimethamine.
Owner:JIANGSU UNIV
Injection calcium folinate composite and preparation method thereof
InactiveCN102178681AReduce or even eliminate the phenomenon of low temperature devitrificationImprove stabilityPowder deliveryHydroxy compound active ingredientsFreeze-dryingAntidote
The invention relates to an injection calcium folinate composite and a preparation method thereof. The calcium folinate composite prepared through the method is mainly used as detoxicant of a folic acid antagonist (such as methotrexate, pyrimethamine or trimethoprim and the like). The injection calcium folinate composite is clinically used for preventing serious toxic actions caused by excessive methotrexate or large dose treatment. The injection calcium folinate composite comprises calcium folinate and mannitol. The preparation method comprises the steps of: 1, preparing: placing the calciumfolinate and the mannitol in a preparing tank according to the weight ratio of 1:(0.1-0.5), adding injection water, adding active carbon for boiling for 20min; 2, aseptically filtering, packaging, half-plugging; and 3, freeze-drying in vacuum to obtain the injection calcium folinate composite. The injection calcium folinate composite has the advantages of simple formula, advanced process, uniformand stable quality, thorough moisture drying and better dissolvability.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD
Medicinal composition and injecta for curing avian toxoplasmosis, and preparation method thereof
InactiveCN101816663ARelieve complicationsAvoid secondary infectionOrganic active ingredientsPharmaceutical product form changeAntioxidantSulfamonomethoxine
The invention relates to a medicinal composition and injecta for curing avian toxoplasmosis, and a preparation method thereof. The medicinal composition comprises the following components in percentage by weight: 18 to 36 percent of sulfamonomethoxine, 16 to 65 percent of sulfamethoxazole, 7 to 18 percent of trimethoprim, 4 to 14 percent of pyrimethamine and 6 to 16 percent of nonsteroidal anti-inflammatory medicament. The injecta comprises the following components in percentage by weight: 5 to 10 percent of sulfamonomethoxine, 4 to 20 percent of sulfamethoxazole, 2 to 5 percent of trimethoprim, 1 to 3 percent of pyrimethamine, 1.5 to 4 percent of nonsteroidal anti-inflammatory medicament, 5 to 10 percent of polyethyleneglycol-400, 10 to 30 percent of propylene glycol, 30 to 60 percent of alpha-pyrrolidone, 0.1 to 0.2 percent of antioxidant, 0.01 to 0.02 percent of metal complexing agent and the balance of water for injection. Sulfamonomethoxine, sulfamethoxazole, trimethoprim and pyrimethamine are jointly applied and a long-acting preparation is prepared by adopting composite solvent, so that the medicinal composition and the injecta can prevent the secondary infection of other pathogen at the same time of destroying and expelling toxoplasma so as to relieve different symptoms and complicating diseases caused by the toxoplasma.
Owner:HENAN HUITONGTIANXIA ANIMAL MEDICINE
New application of pyrimethamine and medicinal composition for treating for tumor
InactiveCN104398517AGood synergyOrganic active ingredientsAntineoplastic agentsActive componentCell growth
The invention belongs to the field of medicines and particularly relates to a new application of pyrimethamine and a medicinal composition for treating for tumor. The new application means the application of the pyrimethamine for treating ovarian cancer. The medicament for treating the ovarian cancer is a medicament prepared by taking the pyrimethamine with effective dose as an active component and adding pharmaceutically-acceptable accessory or auxiliary components. The pyrimethamine disclosed by the invention is used for treating the ovarian cancer, can be used for effectively killing ovarian cancer cells and inhibiting the growth of tumor cells, has good medicinal value and provides a new selection for clinically treating the ovarian cancer.
Owner:SICHUAN UNIV
Controllable genome-modified plasmodium, recombinant expression vector and construction method and application of controllable genome-modified plasmodium and recombinant expression vector
The invention relates to a controllable genome-modified plasmodium, a recombinant expression vector and the construction method and application of the controllable genome-modified plasmodium and the recombinant expression vector. The recombinant expression vector comprises a gene targeting long homologous arm, a gene targeting short homologous arm, a tetracycline repression protein gene expression cassette, a pyrimethamine resistance gene expression cassette and a target gene expression cassette, wherein the tetracycline repression protein gene expression cassette, the pyrimethamine resistance gene expression cassette and the target gene expression cassette are located between the gene targeting long homologous arm and the gene targeting short homologous arm, and tetracycline operator gene sequences are inserted in multiple transcriptional start sites of a target gene promoter, so that the recombinant expression vector can be used for conditional research of the functions of a certain functional gene in a plasmodium genome. Furthermore, a functional gene expression sequence, corresponding to a target gene, in the plasmodium genome is knocked out by means of the gene knockout technique; meanwhile, the recombinant expression vector is transfected into a plasmodium with genes knocked out, so that the controllable genome-modified plasmodium is obtained; a new technical scheme is provided for further research of the functions of all functional genes in the plasmodium genome, and application prospects are broad.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
Preparation of chicken eimeria tenella strain with EYFP knocked into Et.Actin gene
PendingCN113583876ANo distractionSolve pollutionProtozoaStable introduction of DNAAnticoccidial AgentsCecum mucosa
The invention discloses preparation of a chicken eimeria tenella strain with EYFP knocked into an Et.Actin gene. According to the invention, an FnCas12a protein, crRNA synthesized in vitro and a homologous recombination fragment (an Et.Actin gene containing a P2A-DHFR-EYFP expression cassette) are introduced into chicken eimeria tenella sporozoite by utilizing a Lonza 4D-Nucleofector nuclear transformation instrument, so that the editing of the chicken eimeria tenella is realized. The edited insect strain is screened through pyrimethamine in a chicken body to obtain a high-purity gene edited insect strain. Then, the gene edited insect strain is verified by utilizing PCR and Sanger sequencing technologies, and it is proved that the EYFP successfully marks the Et.Actin gene. After sporozoites of the strain are subjected to cell culture and a chicken is infected, cecum mucosa is taken and smeared to show that the EYFP is expressed in the whole life history of the gene edited strain. The gene editing method can be used for performing fixed-point marking on a chicken coccidiosis gene, and is beneficial to analyzing the function of the coccidiosis gene. The invention also has important significance for research and development of novel anticoccidial drugs and vaccines.
Owner:SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
Enhanced immunotherapy of cancer using targeted transcriptional modulators
ActiveUS20200230135A1Improving immunogenicityImprove efficiencyOrganic active ingredientsPharmaceutical delivery mechanismDiseaseAntiendomysial antibodies
The present invention relates to a combination of a signal transducer and activator of transcription 3 (STAT3) activity inhibitor; and an immune checkpoint inhibitor for use in treating or preventing the hyperproliferative disorder in a subject. Preferably, the STA3 activity inhibitor is pyrimethamine or atovaquone, and the immune checkpoint inhibitor is an anti-PD1 antibody. Preferably, the hyperproliferative disorder is a glioma or a glioblastoma.
Owner:DANA FARBER CANCER INST INC
Anti-toxoplasma composition drug and screening method thereof
ActiveCN104998277AGood against Toxoplasma gondiiClean up thoroughlyOrganic active ingredientsAntiparasitic agentsSulfamonomethoxineSulfanilamide
The invention discloses an anti-toxoplasma composition drug and a screening method thereof, and belongs to the field of medicine. According to the anti-toxoplasma composition drug and the screening method thereof, mouse test toxoplasmosis animal models are established, the ten drugs of a sulfadiazine sodium injection, a compound sulfamethoxazole, a lincomycin hydrochloride injection, a sulfamonomethoxine sodium injection, a florfenicol injection, acetylspiramycin, pyrimethamine, roxithromycin, artemisinin and radix sophorae flavescentis are selected out, two compositions which have the best anti-toxoplasma effect are screened out, one composition comprises the sulfamonomethoxine, the pyrimethamine and TMP, and the other composition comprises the compound sulfamethoxazole and the acetylspiramycin; animal models in mice and pigs are established, it is verified that the two compositions are both effective on the treatment of artificially infected toxplasmosis in pigs, and the treatment effect on the pigs is in accordance with that of the mouse models. By means of the anti-toxoplasma composition drug and the screening method thereof, it is proved that the the feasible method is achieved by utilizing the mouse test toxoplasmosis models to evaluate the efficacy of drugs on treating toxplasmosis in pigs, and meanwhile two anti-toxoplasma drug compositions with good effects are provided.
Owner:SOUTH CHINA AGRI UNIV
Synergistic combination kit of alpha,beta-arteether, sulfadoxin and pyrimethamine for treatment of severe/multi-drug resistant cerebral malaria
InactiveUS20060141024A1Significant clinical effectToxic reductionBiocideOrganic active ingredientsGreek letter betaMalaria
The present invention relates to a method for preparation of synergistic combination kits of α,β-arteether, sulfadoxin and pyrimethamine for the treatment of severe / multi-drug resistant cerebral malaria.
Owner:COUNCIL OF SCI & IND RES
Microencapsulated preparation for preventing and treating chicken leukocytopathy and preparation method
InactiveCN109172599AMicrocapsules have a smooth surfaceUniform colorOrganic active ingredientsAntiparasitic agentsAstragalus polysaccharideAfter treatment
The invention discloses a microencapsulated preparation for preventing and treating chicken leukocytopathy, which comprises the following components in parts by weight: 0.1-2 parts of pyrimethamine, 1-10 parts of astragalus polysaccharide, 40-80 parts of carrier and 30-70 parts of emulsifier. The invention provides a microencapsulated preparation containing pyrimidine for preventing and treating chicken leukocytopathy, combined with Astragalus polysaccharide, which can enhance immunity and improve production performance of chicken, pyrimidine can effectively improve drug efficacy and reduce side effects of pyrimidine, so that the body can recover quickly after treatment.
Owner:FOSHAN STANDARD BIO TECH
Toxoplasma wx2 gene deletion strain, construction method and application
PendingCN111304088AMake sure the functionality is completely missingPromote growthProtozoa antigen ingredientsProtozoaRh strainDrug target
The invention discloses a toxoplasma wx2 gene deletion strain, a construction method and application. The wx2 gene of a toxoplasma RH strain is knocked out through CRISPR / Cas9 technology to successfully obtain the wx2 gene deletion strain with pyrimethamine drug resistance. The specific method is that CRISPR plasmid Psag1-Cas9-U6-sgwx2 and drug-resistant fragment wx2-DHFR are constructed, targetedshearing of the CRISPR plasmid and homologous recombination of the drug-resistant fragment are utilized, the identification of a monoclonal strain and a monoclonal deletion strain is carried out through drug screening, and the wx2 gene deletion strain of the toxoplasma RH strain can be successfully obtained. The toxoplasma wx2 gene deletion strain lays a solid foundation for the study of molecular mechanism of growth of the toxoplasma, and provides a theoretical basis for development of the toxoplasma vaccines and study of the toxoplasma drug target molecules.
Owner:CENT SOUTH UNIV
Antimalarial pyrimidine derivatives and methods of making and using them
Compounds of the formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group have been found to possess antimalarial activity against Plasmodium falciparum lines, including those resistant against pyrimethamine and other antifolates. The compounds themselves, methods of making these compounds, and methods of using these compounds are all disclosed.
Owner:NAT SCI & TECH DEV AGENCY
New application of pyrimethamine and medicinal composition containing pyrimethamine
InactiveCN101843620AReduce synthesisInhibition of divisionOrganic active ingredientsAntiparasitic agentsAdditive ingredientBULK ACTIVE INGREDIENT
The invention discloses a new application of pyrimethamine and a medicinal composition containing the pyrimethamine. The new application is characterized in that: the new application relates to the application of the pyrimethamine in preparing medicaments for preventing and controlling leucocyto zoonosis; and the medicament for preventing and controlling the leucocyto zoonosis is prepared by taking an effective dose of pyrimethamine as an active ingredient and adding pharmaceutically accepted auxiliary materials or auxiliary ingredients. When the pyrimethamine is used for preventing and controlling the leucocyto zoonosis, some functions of chicken bodies are improved, and the productivity of the chicken is also improved. Thus, a new choice for preventing and controlling the leucocyto zoonosis in clinic is provided.
Owner:FOSHAN STANDARD BIO TECH
Oral disintegrating tablet for preventing and treating toxoplasmosis for cats and preparation method thereof
InactiveCN103690546BGood synergyEasy to produceOrganic active ingredientsPill deliveryDrug synergismOrally disintegrating tablet
Owner:LIAOCHENG UNIV
Molecular microemulsion for preventing and treating chicken leukocytosis and preparation method thereof
PendingCN109223710AResidue reductionEnsure safetyOrganic active ingredientsPharmaceutical non-active ingredientsAstragalus polysaccharideLeukocytosis
The invention discloses a molecular microemulsion for preventing and treating chicken leukocytosis. The molecular microemulsion comprises the following components in parts by weight: 0.1 to 1.5 partsof pyrimethamine, 1 to 10 parts of astragalus polysaccharide, 3 to 20 parts of emulsifier, 0.01 to 0.8 part of antioxidant, 1 to 20 parts of solvent and 0.05 to 1 part of preservative. Combined withAstragalus polysaccharide which can enhance immunity and improve production performance, pyrimidine can be used to prevent and treat leukococcosis in chickens, which can effectively improve the efficacy and reduce the side effects of pyrimidine, and make the body recover quickly after treatment.
Owner:FOSHAN STANDARD BIO TECH
Orally disintegrating tablet for preventing and treating toxoplasmosis and preparation method thereof
InactiveCN103690546AGood synergyEasy to produceOrganic active ingredientsPill deliveryDrug synergismTrimethoprim
The invention discloses an orally disintegrating tablet for preventing and treating and a preparation process thereof, and belongs to the field of veterinary drug preparations. The orally disintegrating tablet comprises the following components in parts by weight: 0.01-0.2 parts of pyrimethamine, 0.1-0.2 parts of sulfamethoxazole, 0.03-0.04 parts of trimethoprim, 20-30 parts of disintegrating agent, 15-40 parts of filler, 1-2 parts of lubricant, 1-5 parts of flow aid, 2-5 parts of adhesive, 1-2 parts of surfactant, and 1-2 parts of flavoring agent. According to the orally disintegrating tablet, pyrimethamine, sulfamethoxazole and trimethoprim are combined to prepare the orally disintegrating tablet, the principle of drug combination is accorded, the drug synergism can be improved, and the administration times can be reduced. The preparation is an orally disintegrating tablet, has the characteristics of simple production, accurate dosage and high bioavailability, has a key point that the administration means of medicine is changed, and can be used for solving the problem that a pet cat cannot be easily subjected to injection administration and oral tablet administration. The orally disintegrating tablet can be taken without water, does not need swallow, can be disintegrated in the oral cavity when encountering saliva, and can be absorbed by virtue of oral mucosa.
Owner:LIAOCHENG UNIV
Application of hycanthone in preparation of medicine for treating toxoplasma gondii infection diseases
InactiveCN113398118AEffective chronic infectionStrong inhibitory activityOrganic active ingredientsAntiparasitic agentsSide effectGondii toxoplasma
The invention relates to the technical field of parasitic disease prevention and treatment, and provides application of hycanthone in preparation of a medicine for treating toxoplasma gondii infection diseases. It is found that the thioxanthene compound hycanthone has remarkable inhibitory activity on virulent or attenuated toxoplasma gondii of different genotypes and can inhibit proliferation of the toxoplasma gondii, and tests find that after hycanthone acts on the toxoplasma gondii in cells for 24 h, the survival rate of the toxoplasma gondii is only 14.57%, and the hycanthone is superior to that of an existing drug pyrimethamine for treating the toxoplasma gondii. The medication spectrum of the hycanthone is developed, an effective medicine with low side effect is provided for treating acute and chronic toxoplasma gondii infection, and a good application prospect is achieved.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
Separation detection method for pyrimethamine
ActiveCN106117558AImprove adsorption capacityHigh selectivityOrganic chemistryComponent separationChemical reactionFunctional monomer
The invention discloses a separation detection method for pyrimethamine. The separation detection method for pyrimethamine comprises the following steps that firstly, a sample is treated, and a solution to be detected is obtained; secondly, a pyrimethamine molecularly-imprinted polymer is added into the solution to be detected and is separated through centrifuging; thirdly, pyrimethamine is eluted with a certain volume of an eluting solvent, and eluant is collected; fourthly, the concentration of pyrimethamine in the eluant is measured with HPLC / UV, pyrimethamine serves as a template of the pyrimethamine molecularly-imprinted polymer, functional monomers silicon dioxide microspheres with grafted double bonds, a sulphydryl cross-linking agent and the like are added, and pyrimethamine is obtained through a sulphydryl-alkenyl click reaction. According to the pyrimethamine molecularly-imprinted polymer, the sulphydryl cross-linking agent is used in the preparing process, the sulphydryl-alkenyl click chemistry is used in combination with the molecular imprinting technology, the reaction conditions are mild, and the adsorption capacity and the selective performance to pyrimethamine are improved by optimizing the reaction conditions of synthesizing the molecularly-imprinted polymer through the sulphydryl-alkenyl click reaction.
Owner:FOSHAN UNIVERSITY
Compounds for the treatment of lysosomal storage diseases
InactiveUS20150272951A1Treat, prevent, and/or alleviate the lysosomal storage diseaseOrganic active ingredientsBiocideLysosomal enzyme defectPyrimethamine
Owner:HOSPITAL FOR SICK CHILDREN
A kind of anti-toxoplasma gondii prescription drug and its screening method
ActiveCN104998277BGood against Toxoplasma gondiiClean up thoroughlyOrganic active ingredientsAntiparasitic agentsRoxithromycinSulfamonomethoxine
The invention discloses an anti-toxoplasma composition drug and a screening method thereof, and belongs to the field of medicine. According to the anti-toxoplasma composition drug and the screening method thereof, mouse test toxoplasmosis animal models are established, the ten drugs of a sulfadiazine sodium injection, a compound sulfamethoxazole, a lincomycin hydrochloride injection, a sulfamonomethoxine sodium injection, a florfenicol injection, acetylspiramycin, pyrimethamine, roxithromycin, artemisinin and radix sophorae flavescentis are selected out, two compositions which have the best anti-toxoplasma effect are screened out, one composition comprises the sulfamonomethoxine, the pyrimethamine and TMP, and the other composition comprises the compound sulfamethoxazole and the acetylspiramycin; animal models in mice and pigs are established, it is verified that the two compositions are both effective on the treatment of artificially infected toxplasmosis in pigs, and the treatment effect on the pigs is in accordance with that of the mouse models. By means of the anti-toxoplasma composition drug and the screening method thereof, it is proved that the the feasible method is achieved by utilizing the mouse test toxoplasmosis models to evaluate the efficacy of drugs on treating toxplasmosis in pigs, and meanwhile two anti-toxoplasma drug compositions with good effects are provided.
Owner:SOUTH CHINA AGRI UNIV
A kind of comprehensive prevention and control method of palm leaf raspberry wilt
Owner:ZHEJIANG JINHENG HEALTH TECH CO LTD +1
Enhanced immunotherapy of cancer using targeted transcriptional modulators
ActiveUS11285149B2Improving immunogenicityImprove efficiencyPharmaceutical delivery mechanismImmunoglobulins against cell receptors/antigens/surface-determinantsDiseaseAntiendomysial antibodies
Owner:DANA FARBER CANCER INST INC
A kind of separation and detection method of pyrimethamine
ActiveCN105738498BEfficient separation and detection methodComponent separationFunctional monomerUltraviolet
The invention discloses a method for separation and detection of pyrimethamine, which comprises the following steps: (1) adding acetonitrile to the sample, shaking and mixing, centrifuging, taking the supernatant and drying it with nitrogen, and redissolving the residue with a solvent as The solution to be tested; (2) adding the magnetic molecularly imprinted polymer to the test solution, shaking for 20-120 minutes, magnetically separating the magnetically imprinted polymer; (3) eluting the magnetically imprinted polymer with a certain volume of elution solvent pyrimethamine in the eluate, and collect the eluate; (4) measure the concentration of pyrimethamine in the eluate with HPLC / UV; The functional monomer is prepared. The magnetic molecularly imprinted polymer used in the present invention uses multiple hydrogen bond interactions between template molecules and functional monomers to form an intermolecular interaction matrix, strengthen the interaction between template molecules and functional monomers, and improve the affinity for pyrimethamine and selective.
Owner:SOUTH CHINA NORMAL UNIVERSITY
Controllable Genome Modification Plasmodium, Recombinant Expression Vector and Construction Method, Application
The invention relates to a controllable genome-modified plasmodium, a recombinant expression vector and the construction method and application of the controllable genome-modified plasmodium and the recombinant expression vector. The recombinant expression vector comprises a gene targeting long homologous arm, a gene targeting short homologous arm, a tetracycline repression protein gene expression cassette, a pyrimethamine resistance gene expression cassette and a target gene expression cassette, wherein the tetracycline repression protein gene expression cassette, the pyrimethamine resistance gene expression cassette and the target gene expression cassette are located between the gene targeting long homologous arm and the gene targeting short homologous arm, and tetracycline operator gene sequences are inserted in multiple transcriptional start sites of a target gene promoter, so that the recombinant expression vector can be used for conditional research of the functions of a certain functional gene in a plasmodium genome. Furthermore, a functional gene expression sequence, corresponding to a target gene, in the plasmodium genome is knocked out by means of the gene knockout technique; meanwhile, the recombinant expression vector is transfected into a plasmodium with genes knocked out, so that the controllable genome-modified plasmodium is obtained; a new technical scheme is provided for further research of the functions of all functional genes in the plasmodium genome, and application prospects are broad.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
Preparation method and application of a pyrimethamine molecularly imprinted composite membrane based on double-sided loading of click chemistry
ActiveCN109772178BEasy to separateHigh selectivitySemi-permeable membranesOther chemical processesPolymer scienceFunctional monomer
Owner:JIANGSU UNIV
Separation and detection method of pyrimethamine
ActiveCN105738498AEfficient separation and detection methodComponent separationFunctional monomerUltraviolet
The invention discloses a separation and detection method of pyrimethamine. The separation and detection method comprises the following steps: (1) adding acetonitrile into a sample; after shaking and uniformly mixing, centrifuging; taking supernatant and blowing with nitrogen gas; dissolving residues with a solvent to obtain a solution to be detected; (2) adding a magnetic molecularly imprinted polymer into the solution to be detected; after shaking for 20-120 minutes, magnetically separating the magnetic molecularly imprinted polymer; (3) eluting the pyrimethamine in the magnetic molecularly imprinted polymer with an eluting solvent with a certain volume, and collecting an eluent; and (4) determining the concentration of the pyrimethamine in the eluent by utilizing HPLC / UV (High Performance Liquid Chromatography / Ultraviolet), wherein the magnetic molecularly imprinted polymer is prepared by taking the pyrimethamine as a template and amobarbital as a functional monomer. The magnetic molecularly imprinted polymer provided by the invention forms an intermolecular acting matrix through a multiple-hydrogen-bond effect between a template molecule and the functional monomer, so that the effect between the template molecule and the functional monomer is enhanced, and the affinity and selectivity on the pyrimethamine are improved.
Owner:SOUTH CHINA NORMAL UNIVERSITY
Application of aminothiazole compounds in preparation of medicine for treating toxoplasma gondii infection diseases
PendingCN113509468AStrong inhibitory activityEnhanced inhibitory effectOrganic active ingredientsAntiparasitic agentsGondii toxoplasmaAmino radical
The invention relates to the technical field of parasitic disease prevention and treatment, and provides application of aminothiazole compounds in the preparation of a medicine for treating toxoplasma gondii infection diseases. It is found that the aminothiazole compounds have remarkable inhibitory activity on virulent or attenuated toxoplasma gondii of different genotypes and can inhibit proliferation of the toxoplasma gondii, and the inhibitory effect of the aminothiazole compounds is superior to that of an existing medicine pyrimethamine for treating the toxoplasma gondii. According to the invention, the medication spectrum of the aminothiazole compounds is developed, the effective medicine with low side effect is provided for treating acute and chronic toxoplasma infection, and the application prospect is good.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against Plasmodium falciparum
Owner:NAT SCI & TECH DEV AGENCY
A kind of separation detection method of pyrimethamine
ActiveCN106117558BEasy to operateOrganic chemistryComponent separationFunctional monomerChemical reaction
The invention discloses a separation detection method for pyrimethamine. The separation detection method for pyrimethamine comprises the following steps that firstly, a sample is treated, and a solution to be detected is obtained; secondly, a pyrimethamine molecularly-imprinted polymer is added into the solution to be detected and is separated through centrifuging; thirdly, pyrimethamine is eluted with a certain volume of an eluting solvent, and eluant is collected; fourthly, the concentration of pyrimethamine in the eluant is measured with HPLC / UV, pyrimethamine serves as a template of the pyrimethamine molecularly-imprinted polymer, functional monomers silicon dioxide microspheres with grafted double bonds, a sulphydryl cross-linking agent and the like are added, and pyrimethamine is obtained through a sulphydryl-alkenyl click reaction. According to the pyrimethamine molecularly-imprinted polymer, the sulphydryl cross-linking agent is used in the preparing process, the sulphydryl-alkenyl click chemistry is used in combination with the molecular imprinting technology, the reaction conditions are mild, and the adsorption capacity and the selective performance to pyrimethamine are improved by optimizing the reaction conditions of synthesizing the molecularly-imprinted polymer through the sulphydryl-alkenyl click reaction.
Owner:FOSHAN UNIVERSITY
Method for treating toxoplasmosis by using isoflavanoid compound glabridin
PendingCN113197888AInhibitionPrevent proliferationOrganic active ingredientsOrganic chemistryGondii toxoplasmaGlabridin
The invention discloses a method for treating toxoplasmosis by using an isoflavanoid compound glabridin. The method comprises the following specific steps: step 1, preparing a medicine by using the isoflavanoid compound glabridin; and step 2, resisting invasion of toxoplasma gondii by the prepared medicine. The isoflavanoid compound glabridin has remarkable activity on toxoplasma gondii, can remarkably inhibit invasion and proliferation of the toxoplasma gondii and can be used for treating toxoplasmosis, and the anti-proliferation and anti-invasion effects of the glabridin are even superior to those of an existing clinically used medicine pyrimethamine; and the medicine prepared from the isoflavanoid compound glabridin is effective to acute toxoplasmosis.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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