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Molecular microemulsion for preventing and treating chicken leukocytosis and preparation method thereof

A leukocyte and protozoan disease technology, which is applied in the field of molecular microemulsion and its preparation for the prevention and treatment of chicken leukocytic protozoa disease, can solve the problem of uneven mixing of pyrimethamine addition, damage to the reproductive system of livestock and poultry, and pyrimethamine drug residues To achieve the effect of enhancing cellular immunity and humoral immunity, reducing drug residues, and less toxic and side effects

Pending Publication Date: 2019-01-18
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pyrimethamine has relatively large side effects and a small safety range. Excessive use will damage the reproductive system of livestock and poultry, and it is not easy to recover. When applying it to livestock and poultry, attention should be paid to the dosage and time
[0005] Pyrimethamine Use 1 mg of pyrimethamine per kilogram of body weight to prevent and treat chicken leukocytosis. The effect is good. Common pyrimethamine premixes and granules often cause mixed Uneven situation
Incomplete cleaning during production and use will lead to pyrimethamine drug residues. How to ensure the safety of pyrimethamine use and prevent drug residues during use has always been a key issue in the production and use of pyrimethamine

Method used

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  • Molecular microemulsion for preventing and treating chicken leukocytosis and preparation method thereof
  • Molecular microemulsion for preventing and treating chicken leukocytosis and preparation method thereof
  • Molecular microemulsion for preventing and treating chicken leukocytosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of molecular microemulsion that is used for preventing and treating leukocytic protozoon disease of chicken, comprises the component of following parts by weight:

[0034]

[0035] A method for preparing a molecular microemulsion for preventing and treating leukocytic protozoon disease in chickens, comprising the following steps:

[0036] (1) take each component by weight parts;

[0037] (2) dissolving pyrimethamine with glacial acetic acid to obtain a pyrimethamine solution;

[0038] (3) BHA is dissolved in ethanol and potassium sorbate is dissolved in water to obtain BHA solution and potassium sorbate solution;

[0039] (4) Heat Tween 80 and Tween 20 to 60° C., add the pyrimethamine solution and astragalus polysaccharide in step (2) under heating and stir for 60 minutes until all substances are melted to obtain an emulsion;

[0040] (5) Mix the emulsion obtained in step (4) with the BHA solution and potassium sorbate solution obtained in step (3) and stir ...

Embodiment 2

[0042] A kind of molecular microemulsion that is used for preventing and treating leukocytic protozoon disease of chicken, comprises the component of following parts by weight:

[0043]

[0044] A method for preparing a molecular microemulsion for preventing and treating leukocytic protozoon disease in chickens, comprising the following steps:

[0045] (1) take each component by weight parts;

[0046] (2) dissolving pyrimethamine with glacial acetic acid to obtain a pyrimethamine solution;

[0047] (3) Heat Tween 80 and Tween 20 to 70°C, add pyrimethamine solution and astragalus polysaccharide in step (1) under heating and stir for 60 minutes until all substances are melted to obtain an emulsion;

[0048] (4) BHA is dissolved in ethanol and potassium sorbate is dissolved in water to obtain BHA solution and potassium sorbate solution;

[0049] (5) Mix the emulsion obtained in step (3) with the BHA solution and potassium sorbate solution obtained in step (4) and stir and di...

Embodiment 3

[0051] A kind of molecular microemulsion that is used for preventing and treating leukocytic protozoon disease of chicken, comprises the component of following parts by weight:

[0052]

[0053]

[0054] A method for preparing a molecular microemulsion for preventing and treating leukocytic protozoon disease in chickens, comprising the following steps:

[0055] (1) take each component by weight parts;

[0056] (2) dissolving pyrimethamine with glacial acetic acid to obtain a pyrimethamine solution;

[0057](3) After heating the hydrogenated polyoxyethylene castor oil to 65° C. to melt, add the pyrimethamine solution and astragalus polysaccharide in step (1) under heating and stir for 60 minutes until all the substances are melted to obtain an emulsion;

[0058] (4) BHA is dissolved in ethanol and potassium sorbate is dissolved in water to obtain BHA solution and potassium sorbate solution;

[0059] (5) Mix the emulsion obtained in step (3) with the BHA solution and pot...

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Abstract

The invention discloses a molecular microemulsion for preventing and treating chicken leukocytosis. The molecular microemulsion comprises the following components in parts by weight: 0.1 to 1.5 partsof pyrimethamine, 1 to 10 parts of astragalus polysaccharide, 3 to 20 parts of emulsifier, 0.01 to 0.8 part of antioxidant, 1 to 20 parts of solvent and 0.05 to 1 part of preservative. Combined withAstragalus polysaccharide which can enhance immunity and improve production performance, pyrimidine can be used to prevent and treat leukococcosis in chickens, which can effectively improve the efficacy and reduce the side effects of pyrimidine, and make the body recover quickly after treatment.

Description

technical field [0001] The invention relates to the field of animal medicines, in particular to a molecular microemulsion for preventing and treating leukocytozoonosis in chickens and a preparation method thereof. Background technique [0002] Chicken leukocytozoon disease is a kind of acute blood spore protozoan disease caused by various leukocytozoon parasitic in chicken's white blood cells and red blood cells. Due to the destruction of red blood cells and extensive hemorrhage, sick chickens have pale combs, so they are also called white crown disease. In recent years, the disease has broken out and become popular in many areas of our country, and the harm to the chicken industry is becoming more and more serious. Indigenous Leukocytozoa belong to the phylum Protozoa, the subphylum Polytopia, the class Sporozoa, the suborder Haemosporidia, the family Plasmodium, and the genus Leukocytozoa. my country has found that there are two kinds of leukocytosis in chickens: leukocy...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/715A61K31/505A61P33/02
CPCA61K9/1075A61K31/505A61K31/715A61K47/26A61P33/02A61K2300/00
Inventor 刘肖娟谭志坚黎剑坤翁亚彪符德文陈艺青袁增辉
Owner FOSHAN STANDARD BIO TECH
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