Orally disintegrating tablet for preventing and treating toxoplasmosis and preparation method thereof

A technology for oral disintegrating tablets and toxoplasmosis, which is applied in the field of oral disintegrating tablets for preventing and treating toxoplasmosis for cats and the field of preparation thereof, and can solve the problems of poor taste of ordinary tablet medicines, difficult for cats to be stabilized, and difficult to maintain. Injection and other problems, to achieve the effect of solving compliance problems, reducing the number of administrations, and accurate doses

Inactive Publication Date: 2014-04-02
LIAOCHENG UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for pet cats, because their skin tissue structure is very dense, it is not easy to inject, and cats are not easy to hold, easy to scratch people
For oral tablets, it is a laborious task to stuff the medicine into the cat's mouth, and because the tast

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Recipe: The following is the amount of 1000 tablets, each weighing 150mg, totaling 150g.

[0027] Pyrimethamine 10g

[0028] Sulfamethoxazole 25g

[0029] Trimethoprim 5g

[0030] Low-substituted hydroxypropyl cellulose 7.5g

[0031] Microcrystalline cellulose 30g

[0032] Mannitol 51.5g

[0033] 10g lactose

[0034] Magnesium stearate 2g

[0035] Micro powder silica gel 6g

[0036] Sodium lauryl sulfate 1g

[0037] Fish flavor 1g

[0038] Acesulfame 1g

[0039] Preparation:

[0040] (1) The raw materials pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, mannitol, sodium lauryl sulfate, acesulfame potassium, The lactose and fish flavors are passed through a 100-mesh sieve and set aside.

[0041] (2) Weigh the corresponding amount of pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, mannitol, lactose and fish flavors according to the amou...

Embodiment 2

[0044] Example 2 Clinical trial

[0045] 1. Materials and animals: Toxoplasma prevention and treatment orally disintegrating tablets for cats made in the laboratory (200mg / tablet). Pet cat from the veterinary hospital.

[0046] 2. Experimental method:

[0047] 2.1 Select pet cats from the veterinary hospital for treatment, and the pet cats diagnosed with Toxoplasma gondii by laboratory examination.

[0048] 2.2 The dosage for cats is 1 tablet per 1kg body weight. The route of administration is direct oral administration. Take 1 tablet a day for 7 days.

[0049] 2.3 Dosing compliance inspection: observe the cat's response to medication.

[0050] 2.4 Effect inspection: 7 days after the medication, collect the feces of the treated cat to check whether toxoplasma oocysts are discharged. Set the following indicators respectively:

[0051] Invalid: Toxoplasma oocysts in feces.

[0052] Effective: No Toxoplasma oocysts in feces.

[0053] 3. Experimental results

[0054] 3.1 Observation of medic...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an orally disintegrating tablet for preventing and treating and a preparation process thereof, and belongs to the field of veterinary drug preparations. The orally disintegrating tablet comprises the following components in parts by weight: 0.01-0.2 parts of pyrimethamine, 0.1-0.2 parts of sulfamethoxazole, 0.03-0.04 parts of trimethoprim, 20-30 parts of disintegrating agent, 15-40 parts of filler, 1-2 parts of lubricant, 1-5 parts of flow aid, 2-5 parts of adhesive, 1-2 parts of surfactant, and 1-2 parts of flavoring agent. According to the orally disintegrating tablet, pyrimethamine, sulfamethoxazole and trimethoprim are combined to prepare the orally disintegrating tablet, the principle of drug combination is accorded, the drug synergism can be improved, and the administration times can be reduced. The preparation is an orally disintegrating tablet, has the characteristics of simple production, accurate dosage and high bioavailability, has a key point that the administration means of medicine is changed, and can be used for solving the problem that a pet cat cannot be easily subjected to injection administration and oral tablet administration. The orally disintegrating tablet can be taken without water, does not need swallow, can be disintegrated in the oral cavity when encountering saliva, and can be absorbed by virtue of oral mucosa.

Description

Technical field [0001] The present invention relates to the technical field of veterinary medicine, in particular to an orally disintegrating tablet for preventing and treating toxoplasmosis for cats and a preparation method thereof. Background technique [0002] With the development of my country's economic level and the progress of science and technology, the material and spiritual cultural level of residents has greatly improved. The pet economy has been booming, and the number of pets kept rising sharply. Pet cats are loved by many pet owners for their beauty, docility, and ease of keeping. They not only bring the joy of life to breeders, but also bring spiritual support and comfort to the lonely. Become one of the indispensable family members. [0003] Toxoplasmosis is a zoonotic protozoan caused by toxoplasma infection of animals and humans. The clinical manifestations of the patients are complicated, and their symptoms and signs lack specificity, which can easily cause m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/635A61K9/20A61P33/02A61K31/505
Inventor 褚秀玲苏建青
Owner LIAOCHENG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap