Orally disintegrating tablet for preventing and treating toxoplasmosis and preparation method thereof
A technology for oral disintegrating tablets and toxoplasmosis, which is applied in the field of oral disintegrating tablets for preventing and treating toxoplasmosis for cats and the field of preparation thereof, and can solve the problems of poor taste of ordinary tablet medicines, difficult for cats to be stabilized, and difficult to maintain. Injection and other problems, to achieve the effect of solving compliance problems, reducing the number of administrations, and accurate doses
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Embodiment 1
[0026] Recipe: The following is the amount of 1000 tablets, each weighing 150mg, totaling 150g.
[0027] Pyrimethamine 10g
[0028] Sulfamethoxazole 25g
[0029] Trimethoprim 5g
[0030] Low-substituted hydroxypropyl cellulose 7.5g
[0031] Microcrystalline cellulose 30g
[0032] Mannitol 51.5g
[0033] 10g lactose
[0035] Micro powder silica gel 6g
[0036] Sodium lauryl sulfate 1g
[0037] Fish flavor 1g
[0038] Acesulfame 1g
[0039] Preparation:
[0040] (1) The raw materials pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, mannitol, sodium lauryl sulfate, acesulfame potassium, The lactose and fish flavors are passed through a 100-mesh sieve and set aside.
[0041] (2) Weigh the corresponding amount of pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, mannitol, lactose and fish flavors according to the amou...
Embodiment 2
[0044] Example 2 Clinical trial
[0045] 1. Materials and animals: Toxoplasma prevention and treatment orally disintegrating tablets for cats made in the laboratory (200mg / tablet). Pet cat from the veterinary hospital.
[0046] 2. Experimental method:
[0047] 2.1 Select pet cats from the veterinary hospital for treatment, and the pet cats diagnosed with Toxoplasma gondii by laboratory examination.
[0048] 2.2 The dosage for cats is 1 tablet per 1kg body weight. The route of administration is direct oral administration. Take 1 tablet a day for 7 days.
[0049] 2.3 Dosing compliance inspection: observe the cat's response to medication.
[0050] 2.4 Effect inspection: 7 days after the medication, collect the feces of the treated cat to check whether toxoplasma oocysts are discharged. Set the following indicators respectively:
[0051] Invalid: Toxoplasma oocysts in feces.
[0052] Effective: No Toxoplasma oocysts in feces.
[0053] 3. Experimental results
[0054] 3.1 Observation of medic...
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