Oral disintegrating tablet for preventing and treating toxoplasmosis for cats and preparation method thereof
A technology of orally disintegrating tablets and toxoplasmosis, which is applied in the field of orally disintegrating tablets for the prevention and treatment of toxoplasmosis in cats and its preparation field, can solve the problem of poor taste of ordinary tablet drugs, difficulty in keeping cats in place, and difficulty in Injection and other problems to achieve the effect of solving compliance problems, reducing the number of administrations, and accurate dosage
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Embodiment 1
[0026] Prescription: The following is the amount of 1000 tablets, each weighing 150mg, 150g in total.
[0027] Pyrimethamine 10g
[0028] Sulfamethoxazole 25g
[0029] Trimethoprim 5g
[0030] Low-substituted hydroxypropyl cellulose 7.5g
[0031] Microcrystalline cellulose 30g
[0032] Mannitol 51.5g
[0033] Lactose 10g
[0034] Magnesium stearate 2g
[0035] Micropowder silica gel 6g
[0036] Sodium Lauryl Sulfate 1g
[0037] Fish flavor 1g
[0038] Acesulfame K 1g
[0039] Preparation:
[0040] (1) The raw materials pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, mannitol, sodium lauryl sulfate, acesulfame potassium, Lactose and fish meat flavor essence are respectively passed through a 100-mesh sieve for later use.
[0041] (2) Weigh the corresponding amount of pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulos...
Embodiment 2
[0044] Embodiment 2 clinical trials
[0045] 1. Materials and animals: orally disintegrating tablets (200 mg / tablet) for prevention and treatment of Toxoplasma gondii in cats made in the laboratory. A pet cat from a veterinary hospital.
[0046] 2. Experimental method:
[0047]2.1 Select the pet cats from the veterinary hospital for diagnosis and treatment, and the pet cats diagnosed with Toxoplasma gondii by laboratory examination.
[0048] 2.2 The dosage for cats is 1 tablet per 1kg body weight. The route of administration is direct oral administration. 1 tablet per day for 7 consecutive days.
[0049] 2.3 Administration compliance check: observe the reaction of the cat to the medicine.
[0050] 2.4 Effect check: After 7 days of medication, the feces of the treated cats were collected to check whether there was excretion of Toxoplasma gondii oocysts. Set the following indicators respectively:
[0051] Invalid: Toxoplasma gondii oocysts in feces.
[0052] Effective: N...
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