Oral disintegrating tablet for preventing and treating toxoplasmosis for cats and preparation method thereof

A technology of orally disintegrating tablets and toxoplasmosis, which is applied in the field of orally disintegrating tablets for the prevention and treatment of toxoplasmosis in cats and its preparation field, can solve the problem of poor taste of ordinary tablet drugs, difficulty in keeping cats in place, and difficulty in Injection and other problems to achieve the effect of solving compliance problems, reducing the number of administrations, and accurate dosage

Inactive Publication Date: 2016-05-18
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for pet cats, because their skin tissue structure is very dense, it is not easy to inject, and cats are not easy to hold, easy to scratch people
For oral tablets, it is a laborious task to stuff the medicine into the cat's mouth, and because the taste of ordinary tablet medicine is not good, cats are not willing to swallow it at all, and often spit it out directly
Therefore, cat medication has become a headache for pet breeders, and going to the veterinary hospital every day will delay a lot of time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: The following is the amount of 1000 tablets, each weighing 150mg, 150g in total.

[0027] Pyrimethamine 10g

[0028] Sulfamethoxazole 25g

[0029] Trimethoprim 5g

[0030] Low-substituted hydroxypropyl cellulose 7.5g

[0031] Microcrystalline cellulose 30g

[0032] Mannitol 51.5g

[0033] Lactose 10g

[0034] Magnesium stearate 2g

[0035] Micropowder silica gel 6g

[0036] Sodium Lauryl Sulfate 1g

[0037] Fish flavor 1g

[0038] Acesulfame K 1g

[0039] Preparation:

[0040] (1) The raw materials pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, mannitol, sodium lauryl sulfate, acesulfame potassium, Lactose and fish meat flavor essence are respectively passed through a 100-mesh sieve for later use.

[0041] (2) Weigh the corresponding amount of pyrimethamine, sulfamethoxazole, trimethoprim, low-substituted hydroxypropyl cellulose, microcrystalline cellulos...

Embodiment 2

[0044] Embodiment 2 clinical trials

[0045] 1. Materials and animals: orally disintegrating tablets (200 mg / tablet) for prevention and treatment of Toxoplasma gondii in cats made in the laboratory. A pet cat from a veterinary hospital.

[0046] 2. Experimental method:

[0047]2.1 Select the pet cats from the veterinary hospital for diagnosis and treatment, and the pet cats diagnosed with Toxoplasma gondii by laboratory examination.

[0048] 2.2 The dosage for cats is 1 tablet per 1kg body weight. The route of administration is direct oral administration. 1 tablet per day for 7 consecutive days.

[0049] 2.3 Administration compliance check: observe the reaction of the cat to the medicine.

[0050] 2.4 Effect check: After 7 days of medication, the feces of the treated cats were collected to check whether there was excretion of Toxoplasma gondii oocysts. Set the following indicators respectively:

[0051] Invalid: Toxoplasma gondii oocysts in feces.

[0052] Effective: N...

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PUM

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Abstract

The invention discloses an orally disintegrating tablet for preventing and treating and a preparation process thereof, and belongs to the field of veterinary drug preparations. The orally disintegrating tablet comprises the following components in parts by weight: 0.01-0.2 parts of pyrimethamine, 0.1-0.2 parts of sulfamethoxazole, 0.03-0.04 parts of trimethoprim, 20-30 parts of disintegrating agent, 15-40 parts of filler, 1-2 parts of lubricant, 1-5 parts of flow aid, 2-5 parts of adhesive, 1-2 parts of surfactant, and 1-2 parts of flavoring agent. According to the orally disintegrating tablet, pyrimethamine, sulfamethoxazole and trimethoprim are combined to prepare the orally disintegrating tablet, the principle of drug combination is accorded, the drug synergism can be improved, and the administration times can be reduced. The preparation is an orally disintegrating tablet, has the characteristics of simple production, accurate dosage and high bioavailability, has a key point that the administration means of medicine is changed, and can be used for solving the problem that a pet cat cannot be easily subjected to injection administration and oral tablet administration. The orally disintegrating tablet can be taken without water, does not need swallow, can be disintegrated in the oral cavity when encountering saliva, and can be absorbed by virtue of oral mucosa.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to an orally disintegrating tablet for cats for preventing and treating toxoplasmosis and a preparation method thereof. Background technique [0002] With the development of our country's economic level and the advancement of science and technology, the material and spiritual cultural levels of residents have been greatly improved. The pet economy has developed vigorously, and the number of pets has risen sharply. Pet cats are loved by many pet breeders for their beauty, gentleness and easy feeding. They not only bring the joy of life to the breeders, but also bring spiritual support and comfort to the lonely. Become one of the indispensable family members. [0003] Toxoplasmosis is a zoonotic protozoan disease caused by toxoplasma infecting animals and humans. The clinical manifestations of the patients are complicated, and the symptoms and signs lack specificity, w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/20A61P33/02A61K31/505
Inventor 褚秀玲苏建青
Owner LIAOCHENG UNIV
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