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Preparation method and application of a pyrimethamine molecularly imprinted composite membrane based on double-sided loading of click chemistry

A technology of pyrimethamine and molecular imprinting, applied in chemical instruments and methods, inorganic chemistry, and other chemical processes, can solve the problems of lower thermal stability requirements of basement membranes, long and shortened preparation time of molecularly imprinted membranes, etc. Achieve the effect of improved selective separation efficiency, convenient subsequent separation and high selectivity

Active Publication Date: 2021-05-25
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the deficiencies in the above-mentioned prior art, the purpose of the present invention is to overcome the technical defects in the prior art, solve the problems of long preparation time, high temperature, and low selectivity of traditional molecularly imprinted membranes, and make the thermal stability of the basement membrane The requirements are greatly reduced, the preparation time is greatly shortened, and the selective separation efficiency of the target molecule (pyrimethamine) is greatly improved

Method used

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  • Preparation method and application of a pyrimethamine molecularly imprinted composite membrane based on double-sided loading of click chemistry
  • Preparation method and application of a pyrimethamine molecularly imprinted composite membrane based on double-sided loading of click chemistry
  • Preparation method and application of a pyrimethamine molecularly imprinted composite membrane based on double-sided loading of click chemistry

Examples

Experimental program
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Effect test

Embodiment 1

[0057] S1, preparation of dopamine-modified basement membrane:

[0058] Dissolve 0.1211g tris(hydroxymethyl)aminomethane hydrochloride and 0.2g dopamine hydrochloride in 100mL water to obtain a mixed solution, use a dilute solution of hydrochloric acid and sodium hydroxide to adjust the pH value of the solution to 8.5, and place the basement membrane (diameter 25mm) Immerse in the mixed solution, shake at room temperature for 3 hours, wash with water and dry to modify the basement membrane with dopamine.

[0059] S2. Preparation of double-sided carbon nanotube supported film:

[0060] Mix 0.01g of carbon nanotubes, 0.42g of N,N-dimethyl-N-(3-sulfopropyl)-1-octadecyl ammonium inner salt and 4mL of glycerol, add 4mL of an aqueous solution containing 0.01g of κ-carrageenan, After centrifugation at 4250rpm for 15min, the supernatant was taken, and 0.4mL of the supernatant was vacuum-filtered on the surface of the dopamine-modified basement membrane obtained in S1. After drying, 0...

Embodiment 2

[0076] S1, preparation of dopamine-modified basement membrane:

[0077] Dissolve 0.1211g tris(hydroxymethyl)aminomethane hydrochloride and 0.2g dopamine hydrochloride in 100mL water to obtain a mixed solution, use a dilute solution of hydrochloric acid and sodium hydroxide to adjust the pH value of the solution to 8.5, and place the basement membrane (diameter 25mm) Immerse in the mixed solution, shake at room temperature for 6 hours, wash with water and dry to modify the basement membrane with dopamine.

[0078] S2. Preparation of double-sided carbon nanotube supported film:

[0079] Mix 0.12g of carbon nanotubes, 0.42g of N,N-dimethyl-N-(3-sulfopropyl)-1-octadecyl ammonium inner salt and 4mL of glycerin and grind for 20min, add 4mL containing 0.01gκ-carrageenan After the aqueous solution was ground for 40 minutes, centrifuged at 4250 rpm for 15 minutes, the supernatant was taken and diluted with water to 1 / 20 of the original concentration, and 0.4 mL of the diluted solution...

Embodiment 3

[0096] S1, preparation of dopamine-modified basement membrane:

[0097] Dissolve 0.1211g tris(hydroxymethyl)aminomethane hydrochloride and 0.2g dopamine hydrochloride in 100mL water to obtain a mixed solution, use a dilute solution of hydrochloric acid and sodium hydroxide to adjust the pH value of the solution to 8.5, and place the basement membrane (diameter 25mm) Immerse in the mixed solution, shake at room temperature for 24 hours, wash with water and dry to modify the basement membrane with dopamine.

[0098] S2. Preparation of double-sided carbon nanotube supported film:

[0099] Mix 0.50g of carbon nanotubes, 0.42g of N,N-dimethyl-N-(3-sulfopropyl)-1-octadecyl ammonium inner salt and 4mL of glycerin and grind for 30min, add 4mL containing 0.01gκ-carrageenan After the aqueous solution was ground for 60 minutes, centrifuged at 4250 rpm for 15 minutes, the supernatant was taken and diluted with water to 1 / 40 of the original concentration, and 0.4 mL of the diluted solutio...

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Abstract

The invention belongs to the technical field of preparation of functional materials, and discloses a preparation method and application of a pyrimethamine molecularly imprinted composite membrane based on double-sided loading of click chemistry; the preparation steps are as follows: dopamine is used as a bionic modification material, and carbon nanotubes are used as a membrane Loading material, pyrimethamine as template molecule, methacrylic acid as functional monomer, tetrakis(3-mercaptopropionate) pentaerythritol ester as cross-linking agent, dipentaerythritol pentyl- / hexyl-acrylic acid as auxiliary cross-linking agent, combined with double-sided Suction filtration loading means, based on the "click chemistry" polymerization method, prepares a double-sided loaded pyrimethamine molecularly imprinted composite membrane; the double-sided loaded pyrimethamine molecularly imprinted composite membrane prepared by the present invention effectively solves the problem of existing pyrimethamine molecularly imprinted composite membranes. Molecularly imprinted polymers have the disadvantages of difficult recovery and secondary pollution; in addition, they have good specific recognition and adsorption and separation capabilities for pyrimethamine.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional materials, and in particular relates to a preparation method and application of a pyrimethamine molecularly imprinted composite film loaded on both sides based on click chemistry. Background technique [0002] Pyrimethamine is a broad-spectrum antibacterial veterinary drug, mainly used for the prevention and treatment of chicken coccidiosis, fowl cholera and pullorum of piglets. In addition, pyrimethamine is also widely used in the aquaculture industry. Appropriate use can enhance the disease resistance of aquatic animals. However, pyrimethamine has a high degree of accumulation in aquatic products. If it exceeds a certain range, human consumption will destroy the human hematopoietic system, cause hemolytic anemia, and even cause potential carcinogenicity. At the same time, it has a direct effect on the central nervous system. Toxic effects. In 2017, the list of carcinogens rel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D69/12B01D69/02B01D67/00B01J20/26B01J20/28B01J20/30C08F220/06C08F222/20C08J9/26
Inventor 卢健秦莹莹董泽清于超吴易霖孟敏佳李春香闫永胜
Owner JIANGSU UNIV
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