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New application of pyrimethamine and medicinal composition for treating for tumor

A technology of pyrimethamine and composition, applied in the directions of drug combination, antitumor drug, medical preparation containing active ingredient, etc.

Inactive Publication Date: 2015-03-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no relevant report about using pyrimethamine as an active ingredient or a pharmaceutical composition containing pyrimethamine for the treatment of ovarian cancer

Method used

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  • New application of pyrimethamine and medicinal composition for treating for tumor
  • New application of pyrimethamine and medicinal composition for treating for tumor
  • New application of pyrimethamine and medicinal composition for treating for tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] 1. Materials and methods

[0018] 1.1 Materials

[0019] Female BALB / C nude mice were provided by Jianyang Dashuo Animal Technology Co., Ltd.; pyrimethamine was provided by sigma company with molecular formula C12H13ClN4, molecular weight: 248.7114, CAS number: 58-14-0; DMSO was provided by sigma company with a purity of >99.5% ; DMEM medium was purchased from Gibio BRL; Fetal calf serum (FCS): purchased from Gibio BRL; Amikacin was purchased from sigma; Digestion with trypsin (Tyrisin) was purchased from Invitrogen;

[0020] 1.2 Reagent preparation

[0021] DMEM complete medium: Add 400mL of ultrapure water, 50mL of 10×DMEM, 50mL of 10% fetal bovine serum and 50mg of amikacin into a 500mL sterile bottle in turn in the ultra-clean bench, tighten the bottle cap, and mix well Store at 4°C.

[0022] 1.3 Cell culture

[0023] SKOV3 cells are adherent cells and cultured in DMEM tissue culture medium containing 10% fetal bovine serum and amikacin. When passaging, take ou...

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Abstract

The invention belongs to the field of medicines and particularly relates to a new application of pyrimethamine and a medicinal composition for treating for tumor. The new application means the application of the pyrimethamine for treating ovarian cancer. The medicament for treating the ovarian cancer is a medicament prepared by taking the pyrimethamine with effective dose as an active component and adding pharmaceutically-acceptable accessory or auxiliary components. The pyrimethamine disclosed by the invention is used for treating the ovarian cancer, can be used for effectively killing ovarian cancer cells and inhibiting the growth of tumor cells, has good medicinal value and provides a new selection for clinically treating the ovarian cancer.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of pyrimethamine and a pharmaceutical composition for treating tumors. Background technique [0002] Gynecological malignant tumors seriously endanger women's health. Ovarian cancer is one of the three major malignant tumors of the female reproductive system. Its onset is hidden. About 75% of patients are in the advanced stage when they are diagnosed clinically. According to reports, there are 230,000 new ovarian cancer patients in the United States every year, and more than 140,000 patients die during the same period. In recent years, the incidence of ovarian cancer in China has also increased year by year. Although cytoreductive surgery combined with chemotherapy has benefited patients with advanced ovarian cancer, its five-year survival rate is still very low, hovering at 25-30%. [0003] Pyrimethamine (daraprim) is a synthetic non-quinoline antimalarial...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61P35/00
CPCA61K31/505A61K45/06
Inventor 易韬周鸿鹰赵霞
Owner SICHUAN UNIV
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