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Compound fluorophenylnico injection, prepn. method and use thereof

A technology of florfenicol and injection, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of reducing curative effect, and achieve improved survival rate, weight gain, The effect of broadening the antimicrobial spectrum

Inactive Publication Date: 2006-11-15
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, tylosin has been listed as the first choice drug for the treatment of mycoplasma pneumonia in swine all over the world. Due to the long-term repeated use of an antibiotic, the pathogenic microorganisms have developed resistance to the drug, reducing the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Compound florfenicol injection is prepared by the following method:

[0026] (1) Take 2.5 grams of florfenicol, 2 grams of doxycycline, 30 grams of dimethylformamide, 2.5 grams of magnesium dichloride, 2 grams of polyvinylpyrrolidone, 1 gram of trimethoprim, and 40 grams of propylene glycol ;

[0027] (2) Put the doxycycline and magnesium dichloride into the dimethylformamide, use the dimethylformamide as a complexing agent for complexing doxycycline and magnesium dichloride, 40- Stir at 50°C for 15 minutes to make it complex until clear, then add florfenicol and stir until clear;

[0028] (3) Heat the propylene glycol to 80°C, add the trimethoprim and polyvinylpyrrolidone and stir to dissolve;

[0029] (4) Combine the solution prepared in step (2) and step (3), heat it to 70-75°C under stirring, and keep it for 20 minutes. After the color of the medicinal solution is orange-red and clear, add water for injection to 1000 grams, and then prepare Become a kind of compo...

Embodiment 2

[0031] Compound florfenicol injection is prepared by the following method:

[0032] (1) Take 1 part of florfenicol, 3 parts of doxycycline, 25 parts of dimethylformamide, 2 parts of magnesium dichloride, 1 part of polyvinylpyrrolidone, 0.5 part of trimethoprim, propylene glycol 35 copies;

[0033] (2) Put the doxycycline and magnesium dichloride into the dimethylformamide, use the dimethylformamide as a complexing agent for complexing doxycycline and magnesium dichloride, 40- Stir at 50°C for 10 minutes to make it complex until clear, then add florfenicol and stir until clear;

[0034] (3) Heat the propylene glycol to 75°C, add the trimethoprim and polyvinylpyrrolidone and stir to dissolve;

[0035] (4) Combine the solution prepared in step (2) and step (3), heat it to 70-75°C under stirring, and keep it for 15 minutes. After the color of the liquid is orange-red and clear, add water for injection to 1000 parts, that is, prepare Become a kind of compound florfenicol injecti...

Embodiment 3

[0037] Compound florfenicol injection is prepared by the following method:

[0038] (1) Take 3 parts of florfenicol, 1 part of doxycycline, 35 parts of dimethylformamide, 3 parts of magnesium dichloride, 3 parts of polyvinylpyrrolidone, 2 parts of trimethoprim, propylene glycol by weight 45 copies;

[0039] (2) Put the doxycycline and magnesium dichloride into the dimethylformamide, use the dimethylformamide as a complexing agent for complexing doxycycline and magnesium dichloride, 40- Stir at 50°C for 25 minutes to make it complex until clear, then add florfenicol and stir until clear;

[0040] (3) Heat the propylene glycol to 85°C, add the trimethoprim and polyvinylpyrrolidone and stir to dissolve;

[0041] (4) Combine the solution prepared in step (2) and step (3), heat it to 70-75°C under stirring, and keep it for 20 minutes. After the color of the liquid is orange-red and clear, add water for injection to 1000 parts, and then prepare Become a kind of compound florfenic...

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Abstract

A compound florfenicol injection for treating the pneumonia and bacterial lung infection of pig is prepared from florfenicol, doxycycline, dimethyl formamide, magnesium dichloride, polyvinyl pyrrolidone, trimethoprim and propanediol. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a medicine injection, a preparation method and use, in particular to a compound florfenicol injection, a preparation method and a use. Background technique [0002] Pig asthma is one of the most common symptoms of pig lung disease. The main reason is pneumonia caused by Mycoplasma suis, or pneumonia caused by Gram-positive bacteria or Gram-negative bacteria, which seriously restricts the development of pig industry. develop. For decades, tylosin has been listed as the first choice drug for the treatment of mycoplasma pneumonia in swine all over the world. Due to the long-term repeated use of an antibiotic, the pathogenic microorganisms have developed resistance to the drug, reducing the curative effect. Florfenicol is a special antibiotic for animals. Its mechanism of action is that it can bind to the ribosomes in the cells of pathogenic microorganisms and prevent the extension of the peptide chain in the process of protein fo...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K9/08A61K31/165A61K31/505A61K47/18A61K47/30A61P11/06A61P31/04
Inventor 王连民魏宗生耿强斌
Owner TIANJIN SHENGJI GRP CO LTD
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