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Antibacterial cationic injectable hydrogel dressing and preparation method thereof

A technology for injecting water and cations, which can be used in pharmaceutical formulations, bandages, and drug delivery. It can solve the problems of unstable Schiff base bonds and poor mechanical strength, and achieve improved mechanical strength, good biocompatibility, and good promotion. The effect of repair ability

Pending Publication Date: 2021-10-19
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this hydrogel needs the participation of catalase when forming a gel, and what forms is that the Schiff base bond is unstable, resulting in poor mechanical strength of its gelation. When the mass concentration is 25%, its mechanical strength only reaches 5800Pa

Method used

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  • Antibacterial cationic injectable hydrogel dressing and preparation method thereof
  • Antibacterial cationic injectable hydrogel dressing and preparation method thereof
  • Antibacterial cationic injectable hydrogel dressing and preparation method thereof

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preparation example Construction

[0044] The invention provides a kind of preparation method of antibacterial cationic injectable hydrogel dressing, comprises the following steps:

[0045] a) The multi-arm polyethylene glycol terminated by phthalaldehyde is dissolved in a solvent to obtain solution A;

[0046] b) the cationic polymer is dissolved in a solvent to obtain solution B;

[0047] c) mixing and reacting the solution A and the solution B to obtain an antibacterial cationic hydrogel dressing;

[0048] The steps a) and b) are not limited in sequence.

[0049] Regarding step a): The ortho-phthalaldehyde-terminated multi-armed polyethylene glycol is dissolved in a solvent to obtain solution A.

[0050] In the present invention, the multi-arm polyethylene glycol terminated by phthalaldehyde is selected from one or more of the compounds shown in formula 1 to formula 4:

[0051]

[0052] in:

[0053] p, n, x, m are degrees of polymerization;

[0054]35≤p≤133, 25≤n≤100, 17≤x≤75, 12≤m≤50. If the above-...

Embodiment 1

[0076] 1. Sample preparation:

[0077] S1. At 37°C, dissolve the four-armed polyethylene glycol (n=63) capped with phthalaldehyde shown in formula 2 in PBS buffer solution with pH=7.4 to prepare a solution with a mass fraction of 5%; then , the pH of the system was adjusted to 7.4 with NaOH solution to obtain solution A.

[0078] S2. Dissolve ε-poly L-lysine (molecular weight 5000) in PBS buffer solution with pH=7.4 at 37°C to prepare a solution with a mass fraction of 5%; then, adjust the pH of the system to 7.4, to obtain solution B.

[0079] S3. The mass ratio of multi-armed polyethylene glycol capped with cationic polymer: o-phthalaldehyde = 1: 2, mix solution A and solution B at 37°C, and vortex for 5s to obtain antibacterial cationic hydrogel Gum dressing.

[0080] 2. Sample test:

[0081] (1) Gel forming time:

[0082] The test tube inversion method was used to measure the gelation time of the sample at 37°C, and the results showed that the gelation time of the sam...

Embodiment 2

[0091] 1. Sample preparation:

[0092] Carry out according to the preparation process of embodiment 1, difference is, in step S2, the molecular weight of ε-poly L-lysine is 18000.

[0093] 2. Sample test:

[0094] The test was carried out according to the test method of Example 1, and the result showed that the gelation time was 175±7s. The modulus of elasticity is 9500Pa, see Figure 5 , Figure 5 It is the effect figure of the mechanical properties of the antibacterial cationic hydrogel dressing obtained in embodiment 2. The degradation time is 15d, see Figure 6 , Figure 6 It is the in vitro degradability effect figure of embodiment 2 gained antibacterial cationic hydrogel dressing. Antibacterial live-death test results show: Staphylococcus aureus all died, the results see Figure 7 , Figure 7It is the antibacterial effect figure of embodiment 2 gained antibacterial cationic hydrogel dressing to Staphylococcus aureus.

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Abstract

The invention provides an antibacterial cationic injectable hydrogel and a preparation method thereof. According to the antibacterial cationic injectable hydrogel dressing provided by the invention, hydrogel is obtained by self-crosslinking multi-arm polyethylene glycol, of which the end group is modified by phthalic dialdehyde, as a cross-linking agent with a cationic polymer in a solvent. The antibacterial cationic injectable hydrogel dressing provided by the invention can form gel without participation of catalase, and the obtained antibacterial cationic injectable hydrogel dressing has better gel forming time, does not form gel too slowly or too fast, can be injected for in-situ molding, and can be used for treating deep wounds (hydrogel in the prior art is too fast or too slow in gelling and can only be directly made into gel to be used for superficial wounds); moreover, the mechanical strength of the gel can be improved; and the dressing also has good biocompatibility, degradability and antibacterial property, and good repair promotion capability.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an antibacterial cationic injectable hydrogel and a preparation method thereof. Background technique [0002] In recent years, judging from the global trend, the market demand for multifunctional, new materials and high value-added medical dressings has become increasingly urgent, and the high-end medical dressing industry has ushered in a good opportunity for development. At present, the main manufacturers in this field are international manufacturers such as 3M; with the continuous improvement of technology and quality of domestic manufacturers, there will be a large space for domestic substitution in the field of high-end medical dressings in the future. From 2014 to 2019, the scale of my country's dressing market increased from 3.9 billion yuan to 7.3 billion yuan, and is expected to reach 8.2 billion yuan in 2020. The continuous improvement of people's living standards and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0052A61L26/0061A61L26/009A61L2300/404A61L2400/06A61L2300/412A61L2300/252C08L71/02C08L77/04C08L89/00
Inventor 贺超良邹政张震陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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