Hyaluronic acid derivative self-crosslinking hydrogel with oxidized hydroxyethyl cellulose as crosslinking agent and preparation method thereof

Abstract

The invention belongs to the field of high polymer chemistry, and in particular relates to hyaluronic acid self-crosslinking hydrogel taking oxidized hydroxyethyl cellulose as a crosslinking agent, and a preparation method thereof. The hydrogel is prepared by taking oxidized hydroxyethyl cellulose and aminated hyaluronic acid as raw materials; the prepared hydrogel has high free water content and high swelling property, overcomes the defect that a polar group easily generates stimulus response on an organism, has the characteristics of high water-absorbing and swelling property, rapid hemostasis, high biocompatibility and the like, and particularly exerts high coagulant property, rapid gelation time and high swelling property; and according to the hydrogel, the maximal swelling property reaches 265 percent, the rapidest gelation time reaches 5 seconds, the minimal clotting index BCI is 0.034, and complete clotting can be realized within 5 minutes. The preparation method is simple to operate and favorable for industrialized large-scale production.

Description

Technical field [0001] The invention belongs to the field of polymer chemistry, and specifically relates to a hyaluronic acid derivative self-crosslinking hydrogel using oxidized hydroxyethyl cellulose as a crosslinking agent and a preparation method thereof. Background technique [0002] Hydrogel is a polymer material that can swell in water but is insoluble in water. It forms a three-dimensional network structure through intermolecular cross-linking, and its molecular chain has hydrophilic groups. It is generally believed that hydrogels have good biocompatibility because they contain a large amount of water, which is very similar to body tissues filled with aqueous liquids. With the development of modern technology, hydrogels have many applications in the fields of controlled drug release, tissue engineering, and organ regeneration. Electrospinning is an emerging technology. Its product is a nanofiber network structure with extremely high porosity and surface area. It can simu...

AI Technical Summary

Problems solved by technology

However, the absorption rate of hyaluronic acid in the body is too fast, it is easy to diffuse in the tissue, the residence time is short, and it is difficult to exist stably, which greatly limits the practical application of hyaluronic acid. Therefore, functional modification of hyaluronic acid is required , expand its scope of application and maximize its value

The current reports on hyaluronic acid hydrogels are mainly formed by chemical cross-linking with small molecule cross-linking agents, which generally have problems such as low mechanical strength, uneven network structure, and poor controllability of degradation rate, especially for small molecule cross-linking agents. The combination agent has certain cytotoxicity

However, the use of some oxidized polysaccharides as cross-linking agents has the disadvantages of poor hydrogel stability, high pH sensitivity, high viscosity of cross-linking agents, inconvenient handling, and polar groups contained in them are prone to irritating reactions to the body.

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