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Hemostatic gel suppository

A hemostatic gel and suppository technology, applied in the directions of suppository delivery, blood diseases, cardiovascular system diseases, etc., can solve the problems of secondary bleeding, bleeding ineffective, etc., and achieve the effects of accelerating blood coagulation, being easy to accept, and inhibiting bacterial growth.

Inactive Publication Date: 2009-09-09
大连永兴生物医药孵化器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cushion layer can only stop the bleeding on the surface and has no effect on the bleeding in the cavity. After the gauze block is stuffed to stop the bleeding, it is easy to cause secondary bleeding when it is taken out.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] In 1000g of hemostatic gel suppositories:

[0014] (1) Mix 380g sodium carboxymethylcellulose, 150g sodium alginate, and 400g polyvinyl alcohol;

[0015] (2) Add 50 g of glycerin, 20 g of Tween-80, and 2000 ml of deionized water into (1), and fully stir at a temperature of 50° C. to 90° C. to prepare a composite gel suppository raw material;

[0016] (3) When the temperature of the suppository raw material drops to 45°C, it is injected into a mold for molding, and after cooling and solidifying, a hollow thin-shell suppository is obtained.

Embodiment 2

[0018] In 1000g of hemostatic gel suppositories:

[0019] (1) 320g sodium carboxymethylcellulose, 300g chitosan, 300g polyvinyl alcohol are mixed;

[0020] (2) Add 60g of glycerin, 20g of Tween-80, and 2000ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare the composite gel suppository raw material;

[0021] (3) When the temperature of the suppository raw material drops to 45°C, it is injected into a mold for molding, and after cooling and solidifying, a hollow thin-shell suppository is obtained.

Embodiment 3

[0023] In 1000g of hemostatic gel suppositories:

[0024] (1) 400g sodium carboxymethylcellulose, 130g carbomer, 400g polyvinyl alcohol are mixed evenly;

[0025] (2) Add 50 g of glycerin, 20 g of Tween-80, and 2000 ml of deionized water into (1), and fully stir at a temperature of 50° C. to 90° C. to prepare a composite gel suppository raw material;

[0026] (3) When the temperature of the suppository raw material drops to 45°C, it is injected into a mold for molding, and after cooling and solidifying, a hollow thin-shell suppository is obtained.

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PUM

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Abstract

The invention relates to a hemostatic gel suppository, which is characterized in that the hemostatic gel suppository is compounded by sodium carboxymethyl cellulose and other gels. The suppository has shape of hollow thin shell. The hemostatic gel suppository has the advantages that the hemostatic gel suppository has stronger induction function for the aggregation of platelet, can accelerate the deformation, adhesion, aggregation and release of the platelet so as to accelerate human physiological hemostasis, can activate blood clotting factors XII at a bleeding part to accelerate blood clotting, quickly absorbs water in blood and tissue fluid to form a gel closed blood capillary end face so as to function as mechanical blockage and stanch, can be firmly adhered to a wound surface to mechanically press the wound surface so as to stanch, does not adhere to the skin, has the function of inhibiting bacteria growth, and is accepted more easily by a patient.

Description

technical field [0001] The invention relates to a suppository using gel for hemostasis, which is compounded by sodium carboxymethyl cellulose and other gels. Background technique [0002] Bleeding due to anal fissures, hemorrhoids, etc., nasal bleeding, and vaginal and uterine bleeding due to gynecological diseases are common diseases. At present, the common methods and materials for hemostasis are: gauze block pad compression for hemostasis, and gauze block packing for hemostasis. The cushion layer can only stop the bleeding on the surface and has no effect on the bleeding in the cavity. After the gauze block is packed to stop the bleeding, it is easy to cause secondary bleeding when it is taken out. Contents of the invention [0003] In order to overcome the shortcomings that the gauze pad can only stop bleeding on the surface and the gauze pad is filled with hemostasis, it is easy to cause secondary bleeding after taking it out. Hemostatic suppositories. [0004] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K31/717A61K47/36A61K47/34A61K47/32A61K47/40A61K47/42A61K9/02A61L15/28A61L15/32A61L15/26A61L15/24A61P7/04A61P15/00A61P9/14
Inventor 冯伯智滕锡山
Owner 大连永兴生物医药孵化器有限公司
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