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Preparation method of hydroxyapatite/drug-loaded hydrogel composite coating on surface of micro-arc titanium oxide

A technology of hydroxyapatite and composite coating, which is applied in the direction of surface reaction electrolytic coating, coating, superimposed layer plating, etc. The problems of regionalized loading and poor bioactivity of the implant surface can achieve the effects of good apatite induction ability, good plasticity and toughness, and controllable performance.

Active Publication Date: 2021-04-16
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing techniques cannot enhance the bonding of titanium implants to bone, and the surface of the implant is less bioactive
Chitosan hydrogels with controllable mechanical properties cannot be prepared, and controlled compartmentalized loading of gels cannot be achieved

Method used

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  • Preparation method of hydroxyapatite/drug-loaded hydrogel composite coating on surface of micro-arc titanium oxide
  • Preparation method of hydroxyapatite/drug-loaded hydrogel composite coating on surface of micro-arc titanium oxide
  • Preparation method of hydroxyapatite/drug-loaded hydrogel composite coating on surface of micro-arc titanium oxide

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preparation example Construction

[0032] The preparation method of a kind of micro-arc oxidation titanium surface hydroxyapatite / medicine-loaded hydrogel composite coating of the present invention comprises the following steps:

[0033] 1) Dissolve one or more of lithium salts, calcium salts, tin salts, magnesium salts, potassium salts and sodium salts in water to form an electrolyte, use the titanium sample as the anode, and use the stainless steel tank as the cathode. The sample is immersed in the electrolyte for micro-arc oxidation, and a micro-arc oxidation coating is formed on the surface of the titanium sample; among them, the lithium salt is lithium phosphate, lithium silicate or lithium sulfate, and the calcium salt is calcium phosphate, calcium dihydrogen phosphate, Calcium silicate or calcium sulfate, tin salt as tin silicate, stannous sulfate or stannous pyrophosphate, magnesium salt as magnesium silicate, magnesium sulfate or magnesium phosphate, potassium salt as potassium silicate, potassium dihyd...

Embodiment 1

[0052] 1) Micro-arc oxidation treatment: Disodium EDTA, Ca(H 2 PO 4 ) 2 and NaOH are dissolved in water to form an electrolyte, the concentration of disodium EDTA in the electrolyte is 15g / L, Ca(H 2 PO 4 ) 2 The concentration of NaOH is 12g / L, and the concentration of NaOH is 5g / L. The titanium sample is used as the anode, the stainless steel tank is used as the cathode, and the electrolyte is added to the stainless steel tank, and the titanium sample is immersed in the electrolyte at 30°C for micro-arc oxidation. The parameters of the micro-arc oxidation are as follows: pulse voltage is used for oxidation, The positive pressure is 250V, the negative pressure is 80V, the micro-arc oxidation pulse frequency is 400Hz, the duty cycle is 10%, and the micro-arc oxidation time is 5mim. A micro-arc oxidation coating on the titanium surface was obtained. Among them, the titanium sample is TA2 industrial pure titanium.

[0053] 2) Hydrothermal treatment: adding NaOH to water to ...

Embodiment 2

[0062] 1) Micro-arc oxidation treatment: dissolve lithium phosphate, calcium sulfate and NaOH in water to form an electrolyte, the concentration of lithium phosphate in the electrolyte is 10g / L, the concentration of calcium sulfate is 15g / L, and the concentration of NaOH is 5g / L . The titanium sample is used as the anode, the stainless steel tank is used as the cathode, and the electrolyte is added to the stainless steel tank, and the titanium sample is immersed in the electrolyte at 20°C for micro-arc oxidation. The parameters of the micro-arc oxidation are as follows: pulse voltage is used for oxidation, The positive pressure is 500V, the negative pressure is 80V, the micro-arc oxidation pulse frequency is 500Hz, the duty cycle is 20%, and the micro-arc oxidation time is 7min. A micro-arc oxidation coating on the titanium surface was obtained. Among them, the titanium sample is TA3 industrial pure titanium.

[0063] 2) Hydrothermal treatment: adding NaOH to water to form a...

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Abstract

The invention relates to a preparation method of a hydroxyapatite / drug-loaded hydrogel composite coating on the surface of micro-arc titanium oxide. The preparation method comprises the following steps of: soaking a titanium sample subjected to micro-arc oxidation treatment in an alkaline solution, and carrying out hydrothermal treatment to form a hydroxyapatite bioactive coating on the surface of micro-arc titanium oxide; putting an aluminum template into a culture dish, then adding a mixture of a prepolymer of PDMS and a curing agent, and curing to obtain a PDMS template; and mixing a chitosan aqueous solution and a sodium alginate aqueous solution, adding a drug to obtain a drug-loaded hydrogel solution, adding a photoinitiator to the drug-loaded hydrogel solution, dropwise adding to the template, placing a sample on the PDMS template, curing under ultraviolet light, and carrying out freeze drying. According to the method, a composite coating with a porous structure and a nanorod shape is generated through micro-arc oxidation and hydrothermal treatment, and the bonding strength and the biological activity of the implant and bones are improved. The drug-loaded composite hydrogel is loaded on the surface of the micro-arc titanium oxide through the PDMS template, so that the implant coating is endowed with more biological functions.

Description

technical field [0001] The invention relates to the technical field of metal surface modification, in particular to a method for preparing a hydroxyapatite / drug-loaded hydrogel composite coating on the surface of titanium by micro-arc oxidation. Background technique [0002] As metal materials with good biocompatibility, titanium and titanium alloys are widely used in the field of medical implants. However, its combination with bone tissue is poor, and its elastic modulus does not match that of bone tissue. And its biological inertia limits its development and application. Micro-arc oxidation can form an oxide layer with a microscopic porous structure, which improves the integration of implants and bone tissue. The composition of hydroxyapatite is similar to that of bone tissue, and it has good osteoinductive ability and biological activity. Chitosan has good biocompatibility, biodegradability and antibacterial properties, and is often used as a medical dressing and drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C28/00C25D11/26C23C26/00A61L27/06A61L27/30A61L27/32A61L27/34A61L27/50A61L27/54A61L27/56
CPCY02A50/30
Inventor 周睿周颖李明靳国瑞程嘉辉憨勇
Owner XI AN JIAOTONG UNIV
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