230 results about "Hydrogel composite" patented technology

The invention provides an antibacterial hydrogel composite material and a preparation method thereof. The antibacterial trauma repair material is hydrogel formed by chitosan and gamma-polyglutamic acid according to a mass ratio of 1/0.5-2 through electrostatic interaction, and nano silver is synthesized and loaded in situ on the hydrogel by taking PVP as a dispersant. the preparation method is simple, convenient and quick, and the trauma repair material is high in practicability. The composite hydrogel trauma repair material integrates bactericidal and immune activity, high biocompatibility and hemostatic activity that chitosan has, high water absorbency that gamma-polyglutamic and broad-spectrum antibacterial property and freeness of drug resistance that nano silver has, and composite hydrogel nano silver is small in grain diameter, uniform in distribution and less prone to aggregation, thereby having high antibacterial performance; when the material is used for wound dressing, wound infection can be avoided effectively, and wound healing can be accelerated.

A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 mu m. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method using the fiber-reinforced composite are also provided.

A method for producing a hydrogel/fibre composite comprises: impregnating fibres of a fibrous material with a precursor solution comprising at least one polymerisable, and optionally also crosslinkable, monomer such that at least partial swelling of the fibres takes place; and polymerising, and optionally also crosslinking, the at least one monomer after impregnation and at least partial swelling of the fibres such that the integrity of the fibrous material is at least partially preserved in the resulting hydrogel/fibre composite, provided that the crosslinking is not initiated solely by cation release from the fibres of the fibrous material. The invention provides a hydrogel/fibre composite prepared or preparable by the said method. The hydrogel/fibre composite may be adhesive to human skin with good properties of performance and subsequent painless removal. The composite is found to maintain acceptable strength and structural integrity on hydration or across one or more hydration/dehydration cycle, and thus finds use in, for example, biomedical products where this property is required.

The present invention includes tailored fiber-reinforced hydrogel composites for implantation into a subject. The present invention also includes systems and methods for controlling the relative percent volume of the hydrogel and fibers, cross-linking, fiber orientation, weave and density, such that the material properties of the composite can be controlled and/or customized to match particular tissue types. The composites of the present invention are suitable for repairing or replacing musculoskeletal tissues and/or fibrocartilage, such as the meniscus, ligaments and tendons.

The invention discloses photocatalyst-supported hydrogel as well as a preparation method and an application thereof and belongs to the field of environment function materials and catalysis. The photocatalyst-supported hydrogel comprises a conventional hydrogel composite conductive material and a photocatalysis material, wherein conventional hydrogel comprises acyclic acid/acrylamide hydrogel and can also be hydrogel formed through polymerization of other monomers. The conductive material comprises graphite, graphene and the like, and a photocatalyst can comprise bismuth oxychloride, titanium dioxide and the like. Bismuth oxychloride is immobilized, and the photocatalysis properties of bismuth oxychloride and electrical stimulation responsiveness of the hydrogel are combined. The conductive material in the compound hydrogel can transfer photo-induced electrons produced by bismuth oxychloride under illumination, the mass transfer rate between a catalyst and a pollutant cannot be affected, and the photocatalysis performance of bismuth oxychloride is improved. The synthesis method is simple and efficient, can realize industrial production and can be used for degrading atenolol, other medicines, personal care products and other organic pollutants in water.

The present invention provides an absorbent hydrogel composite for use in the manufacture of an article for application to a fluid-emitting surface, e.g. a wound, the composite having a laminar structure comprising first and second layers, the first layer being a surface contacting layer comprising a porous net structure having a surface contacting face and an outwardly directed face, the second layer comprising a low-crosslinked absorbent hydrogel disposed over the outwardly directed face of the first layer and arranged so that in use it is in fluid flow communication with the surface through apertures of the net structure.

The invention provides a cobaltosic oxide nanowire/reduction-oxidization graphene hydrogel (Co<3>O<4>/rGH) composite electrode material which can be applied to a supercapacitor, and belongs to the technical field of a composite electrode material. The laminated framework of the reduction-oxidization graphene hydrogel is taken as the conductive substrate; the cobaltosic oxide nanowire is grown on the surface of the graphene nano sheet through a hydrothermal reaction so as to enable the cobaltosic oxide nanowire and the reduction-oxidization graphene hydrogel laminated structure to establish the composite material, wherein the composite material is formed by wires/sheets and has a multi-stage micropore structure, so that the electrochemical performance is improved consequently; meanwhile, the composite material has relatively high specific capacity and cycling stability; in addition, the composite material has the characteristics of low-price and easily-available raw materials, low pollution, and the like, simple preparation process, stable technology, and easy operation; and meanwhile, the composite material can satisfy the basic commercial requirements when the composite material is used as the electrode material of the supercapacitor.

A composite of silica aerogel and a hydrogel synthesized by and a method for the sequential formation thereof including the encapsulation of hydrophobic aerogels with PEG hydrogel via photoinitiated polymerization. The aerogel-hydrogel composite has two layers: the outer layer hydrogel layer is hydrophilic, whereas the inner aerogel core is hydrophobic.

The invention relates to a 3D-printed degradable macromolecular scaffold and photo-crosslinked hydrogel composite scaffold. The 3D-printed degradable macromolecular scaffold and photo-crosslinked hydrogel composite scaffold comprises a 3D-printed degradable macromolecular scaffold, wherein the interior of the 3D-printed degradable macromolecular scaffold comprises photo-crosslinked hydrogel with high substitution degree and photo-crosslinked hydrogel with low substitution degree, the photo-crosslinked hydrogel with high substitution degree is crosslinked with the photo-crosslinked hydrogel with low substitution degree, and preferably, a polycaprolactone (PCL) scaffold and methacrylic anhydride gelatin (GelMA) with different substitution degrees are crosslinked and compounded. In the composite scaffold, the 3D-printed degradable macromolecular scaffold has good mechanical properties; the photo-crosslinked hydrogel with high substitution degree has high crosslinking degree, can form a fiber network and micropores, and well supports cells; and the photo-crosslinked hydrogel with low substitution degree has multiple active sites, is beneficial to cell adhesion growth, and can adsorb alarge amount of nutrient solution. Through cooperation of the 3D-printed degradable macromolecular scaffold, the photo-crosslinked hydrogel with high substitution degree and the photo-crosslinked hydrogel with low substitution degree, the composite scaffold is suitable for cell growth and vascularization from an inner layer to an outer layer, and when the composite scaffold is used for medical human body repair, scaffold integration is realized to promote regeneration of new tissues.

The present invention provides a composite material comprising oxidized bacterial cellulose and calcium-deficient hydroxyapatite, and methods for preparing the composite material. The composite material is useful as a bone graft material. In another embodiment, the invention provides a method for tissue repair in a mammal. The method comprises inserting the composite material into cartilage or bone tissue.

The invention discloses photo-crosslinking/electrostatic spinning preparation and an application of a hydrogel composite scaffold with a double-layer skin structure. According to the composite scaffold, a gelatin electrostatic spinning fiber membrane is used as a substrate, and cylindrical gelatin hydrogel is prepared on one surface of the gelatin electrostatic spinning fiber membrane through a photo-crosslinking effect, so that the hydrogel composite scaffold with the double-layer skin structure is obtained. The composite scaffold has a double-layer structure, the fiber membrane is equivalentto the epidermal layer of the skin, foreign matter and pathogen invasion can be blocked, and tissue fluid loss can be prevented; the patterned cylindrical gelatin not only can support cell viabilityand cell adhesion, but also can promote cell migration and proliferation and promote regeneration and formation of skin tissues; due to the unique shape, the composite scaffold has good air permeability, large porosity and pore diameter while good fitness with wounds is guaranteed, transportation of oxygen and nutrient substances of the wounds is facilitated, generation of blood vessels at the wounds can be promoted, the degradation speed of the composite scaffold is close to the wound healing period, and wound healing is facilitated.

The invention discloses a method for preparing injection polylactic acid microcarrier/ chitose aqueous gel composite cradle, grafting the methacrylic acid and lactic acid onto the chitose molecular chain in order with carbodiimide condensation method, and getting the polymerized water soluble chitose derivative, mixing the polylactic acid microcarrier and chitose aqueous gel, adding thickening agent konjak glucomannan to increase the viscosity of the prepolymer solution to guarantee the polylactic acid microcarrier suspension, which is facilitate for the injection operation, employing the redox initiating system of ammonium peroxodisulfate and tetramethylethylenediamine to make the composite mentioned above gelify to composite cradle of cell microcarrier/ chitose aqueous gel under body temperature in home position. The process of this invention is simple, the prepared composite cradle not only solves the problems of uneasy to shape and mobile of the injection microcarrier in the body, but also can distinctively increase the aqueous gel intensity. The composite cradle is non toxic, biodegradable and biological compatibility, and is expected to be used for injection cradle in tissue engineering.

The invention discloses a metal nanoparticle loaded on graphene hydrogel composite material and a preparation method and an application thereof. The composite material is prepared by executing the following steps: uniformly dispersing graphene oxide into a weakly acidic aqueous solution containing a metal salt, performing a water bath reaction at 80-100 DEG C, cooling and washing, naturally shrinking and drying at the room temperature, and then performing heat treatment at 130-140 DEG C under a reducing atmosphere. The composite material maintains a small particle size of metal nanoparticles and is uniformly loaded on the surface of graphene, the average particle size of the metal nanoparticles is 1-5nm, a high density and a self-supporting structure are also realized, and the density canreach 1.5-2.0g/cm3. According to the scheme of the invention, the composite material is prepared by a one-step water bath ion induction method, the composite material can add a binding agent to directly serve as an electrode of a lithium ion battery or a sodium ion battery after being sliced, and can achieve the electrochemical performance of high volume specific capacity, high rate performance and high cycling stability.

The invention belongs to the field of functional gel composite materials, and particularly discloses a hydrogel composite material with a near-infrared response temperature sensitive characteristic. The hydrogel composite material is mainly prepared from raw materials including polymerization monomers, polydopamine, nanometer celluloses, cross-linking agents and initiators. 2-methyl-2-acrylic acid-2(2-methoxyl ethoxy) ethyl ester and oligo-polyethylene glycol methyl ether methyl methacrylate are mixed with each other according to a molar ratio of (50-100):(0-50) to obtain the polymerization monomers. The invention further discloses a method for preparing the hydrogel composite material. The hydrogel composite material and the method have the advantages that the hydrogel composite materialprepared by the aid of the method is excellent in tenacity and mechanical strength, the temperatures can be quickly increased after near-infrared light irradiation is carried out, phase can be transformed, initial states can be quickly restored after illumination is removed, and the hydrogel composite material is excellent in repeatability; the method includes simple procedures and is easy to operate, and reaction conditions are mild.

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.