The present invention relates to a plaster of Shexiang Zhuifeng Zhipain Ointment and a preparation method thereof. The plaster comprises: a medicinal patch and an independently packaged wetting agent; wherein, the medicinal patch comprises: an adhesive backing layer, adhered to The medicament layer on the backing layer and the covering layer covering the backing layer and the medicament layer; the medicament in the medicament layer is a powdered plaster of Musk Zhuifeng Analgesic Ointment, and the powdery The plaster is mainly prepared from the following raw materials: Raw Aconitum Aconitum, Raw Chuanwu, Frankincense, Myrrh, Raw Nuxychnya, Clove, Cinnamon, Nepeta, Fangfeng, Geranium, Xiangjiapi, Centella asiatica, and bone fragments Tonic, Angelica dahurica, Kaempferum, Ginger, Musk, Rue Extract Powder, Belladonna Liquid Extract Powder, Camphor, Borneolum, Menthol, Wintergreen Oil, Rosin and Zinc Oxide. The plaster agent of the invention has good therapeutic effect, strong air permeability, no allergic stimulation, and convenient tear-off; the method has simple process, low energy consumption, no environmental pollution, and is suitable for large-scale production.