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Salt-tolerant ceramide liposome with skin repairing effect and preparation method of salt-tolerant ceramide liposome

A technology of ceramide lipid and ceramide, which is applied in the field of salt-tolerant ceramide liposome and its preparation, and can solve the problems of instability and liposome structure destruction.

Active Publication Date: 2021-11-19
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]Prepare ceramide into liposome form, which can solve the application problem and skin absorption problem of ceramide, but the traditional ceramide prepared from lecithin and hydrogenated lecithin Liposomes will be unstable when encountering salt components, and the liposome structure will be destroyed

Method used

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  • Salt-tolerant ceramide liposome with skin repairing effect and preparation method of salt-tolerant ceramide liposome
  • Salt-tolerant ceramide liposome with skin repairing effect and preparation method of salt-tolerant ceramide liposome
  • Salt-tolerant ceramide liposome with skin repairing effect and preparation method of salt-tolerant ceramide liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: a kind of preparation method of the salt-resistant ceramide liposome with skin repairing effect, is characterized in that adopting the following steps:

[0048] A. Weigh the above 2% ceramide mixture (ceramide NP: ceramide NG: ceramide AP mass ratio is 22.1:9.2:8.9), salicyl phytosphingosine 0.01%, phytosphingosine 2% , 8% hexyldecanol, 0.5% cholesterol, 20% vegetable oil, 2% liposome membrane material (the mass ratio of hydrogenated lecithin: tricetyl phosphate is 10:0.01), heated to 75 in a stainless steel container ℃, stir with an IKA stirrer at 300rpm until completely dissolved, and this mixture is called the oil phase component;

[0049] B. Weigh the water and 60.49% polyols of the above 5% mass percentage, mix them uniformly in another stainless steel container, and heat to 75°C. This mixture is called the water phase component;

[0050] C. Mix the oil phase components obtained in step A and the water phase components obtained in step B, and use an ...

Embodiment 2

[0052] Embodiment 2: a kind of preparation method of the salt-tolerant ceramide liposome with skin repairing effect, is characterized in that adopting the following steps:

[0053] A. Weigh the above 7% ceramide mixture (ceramide NP: ceramide NG: ceramide AP mass ratio is 22.1:9.5:8.8), 0.3% salicyl phytosphingosine, 0.05% phytosphingosine , 25% hexyldecanol, 2% cholesterol, 4% vegetable oil, 5.5% liposome membrane material (the mass ratio of hydrogenated lecithin: tricetyl phosphate is 5:0.5), heated to 76 in a stainless steel container ℃, stir with an IKA stirrer at 400rpm until completely dissolved, and the mixture is called the oil phase component;

[0054] B. Weigh the water and 40.15% polyol of the above-mentioned 16% by mass percentage, mix them uniformly in another stainless steel container, and heat to 76°C. The mixture is called the water phase component;

[0055] C. Mix the oil phase components obtained in step A with the water phase components obtained in step B, ...

Embodiment 3

[0057] Embodiment 3: a kind of preparation method of the salt-resistant ceramide liposome with skin repairing effect, is characterized in that adopting the following steps:

[0058] A. Weigh the above 5.2% ceramide mixture (ceramide NP: ceramide NG: ceramide AP mass ratio is 22.1:9.5:8.5), salicyl phytosphingosine 0.5%, phytosphingosine 0.02% , 18% hexyldecanol, 1.2% cholesterol, 5% vegetable oil, 6% liposome membrane material (the mass ratio of hydrogenated lecithin: tricetyl phosphate is 3:0.2), heated to 77 in a stainless steel container ℃, stir with an IKA stirrer at 450rpm until completely dissolved, and the mixture is called the oil phase component;

[0059] B. Weigh the water and 49.08% polyol of the above-mentioned 15% by mass percentage, mix them uniformly in another stainless steel container, and heat to 77°C. The mixture is called the water phase component;

[0060] C. Mix the oil phase components obtained in step A with the water phase components obtained in step ...

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Abstract

The invention relates to a salt-tolerant ceramide liposome with a skin repairing effect and a preparation method. The salt-tolerant ceramide liposome is characterized by comprising the following raw material components in percentage by mass: 2%-20% of a ceramide mixture, 0.01%-1% of salicyloyl phytosphingosine, 0.01%-2% of phytosphingosine, 0.5%-5% of cholesterol, 0.01%-20% of vegetable fat, 8%-30% of hexyldecanol, 5%-60% of water, 10%-70% of polyhydric alcohol and 2%-10% of a liposome membrane material. The ceramide mixture is composed of ceramide NP, ceramide NG and ceramide AP according to the mass ratio of 22.1:(8-10):(8-10), and the liposome membrane material is composed of hydrogenated lecithin and tricetyl phosphate according to the mass ratio of (1-10):(0.01-2). The ceramide liposome disclosed by the invention has the advantages of good salt resistance and good repairing effect.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a salt-tolerant ceramide liposome with skin repairing effect and a preparation method thereof. Background technique [0002] With the deterioration of the environment, sudden changes in climate, high pressure of life and work, and excessive skin care, the skin with allergic problems has increased dramatically. [0003] The causes of sensitive skin are complex, and impaired skin barrier function is one of the important reasons. Studies have shown that individuals with sensitive skin have an increased transepidermal water loss rate. It suggests that the permeability of its skin barrier increases, which is the main reason for the generation of sensitive skin. Poor skin barrier function increases the penetration of topical chemicals and reduces the protection of nerve endings, resulting in a significant increase in sensory nerve signal input. Sensitive skin is prone to skin allergies due ...

Claims

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Application Information

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IPC IPC(8): A61K8/68A61K8/92A61K8/34A61K8/55A61K8/63A61K8/14A61Q19/00
CPCA61K8/68A61K8/63A61K8/922A61K8/34A61K8/345A61K8/14A61K8/553A61K8/55A61Q19/00A61K2800/5922
Inventor 蒋丽刚刘晓青黄洁芳杨盼盼涂静平吕璐王丽娜张甜
Owner PROYA COSMETICS
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