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Lyophilized collagen mask and preparation method thereof

A technology of freeze-dried glue and facial mask, applied in the field of medical supplies, can solve the problems of harsh storage conditions, prone to allergies, short storage period, etc., and achieve the effects of reducing transportation and storage costs, good water-locking effect, and strong water-retaining effect.

Pending Publication Date: 2021-03-16
西安博和医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preservation of wet facial masks is not easy. Since the ingredients of the essence are mostly high-nutrient substances, the humid environment with high water activity can easily promote the growth of bacteria or mold. The storage period is short, and antimicrobial agents such as parabens must be added. Preserved with preservatives, it is easy to cause allergies, and then cause contact dermatitis, causing damage to users
[0003] In addition, most of the collagen used in existing facial masks is animal collagen, which has hidden dangers of immune response and virus. It needs to be transported and stored in a cold chain, otherwise it will lose its activity due to variability, and the activity of collagen after production is unstable. Many raw materials with high biological activity are used in facial masks. Systems with high water activity will attenuate and deteriorate easily, which is not conducive to preservation and exert its biological effects, and the preservation period is short and the preservation conditions are harsh
If the existing commercial formula is to be sterile, the product needs to be irradiated with Co 60, but irradiation will cause structural changes in some components, thereby losing their activity
The ingredients of the formula are relatively single, and other ingredients that help skin repair but are not resistant to radiation cannot be compounded

Method used

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  • Lyophilized collagen mask and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A freeze-dried collagen facial mask, comprising the following components in parts by weight: 0.05 part of recombinant human collagen, 0.01 part of sodium hyaluronate, 0.01 part of betaine, 0.01 part of hydroxyethyl cellulose, 0.5 part of vitamin B5, vitamin 0.5 parts of B6, 0.1 parts of vitamin B11, 0.1 parts of vitamin B12, 0.1 parts of cysteine, 0.1 parts of tryptophan, 0.1 parts of methionine, 0.02 parts of tetrahydromethylpyrimidinecarboxylic acid, 1 part of nicotinamide, and 1 part of trehalose , 1 part of pullulan, 1 part of mannitol, and the balance is deionized water.

[0028] Present embodiment also provides a kind of preparation method of freeze-dried collagen facial mask, comprises the steps:

[0029] (1) Pour deionized water into a stirring container, heat to 80°C, then cool down to 65°C;

[0030] (2) Weigh sodium hyaluronate, betaine and hydroxyethyl cellulose according to the above mass ratio, add them into a stirring container, and stir at constant tempe...

Embodiment 2

[0035] A freeze-dried collagen facial mask, comprising the following components in parts by weight: 1 part of recombinant human collagen, 2 parts of sodium hyaluronate, 0.2 part of betaine, 0.2 part of hydroxyethyl cellulose, 3 parts of vitamin B5, vitamin B6 2 parts, 0.5 parts of vitamin B11, 0.5 parts of vitamin B12, 2 parts of cysteine, 2 parts of tryptophan, 2 parts of methionine, 1 part of tetrahydromethyl pyrimidine carboxylic acid, 10 parts of nicotinamide, 10 parts of hydroxyethyl urea 5 parts of trehalose, 5 parts of pullulan, 5 parts of mannitol, and the balance is deionized water.

[0036] Present embodiment also provides a kind of preparation method of freeze-dried collagen facial mask, comprises the steps:

[0037] (1) Pour deionized water into a stirring container, heat to 100°C, then cool down to 75°C;

[0038] (2) Weigh sodium hyaluronate, betaine and hydroxyethyl cellulose according to the above mass ratio, add them into a stirring container, and stir at cons...

Embodiment 3

[0043]A freeze-dried collagen facial mask, comprising the following components in parts by weight: 0.5 parts of recombinant human collagen, 0.08 parts of sodium hyaluronate, 0.08 parts of betaine, 0.08 parts of hydroxyethyl cellulose, 1.5 parts of vitamin B5, 1.2 parts of vitamin B6, 0.3 parts of vitamin B11, 0.3 parts of vitamin B12, 1 part of cysteine, 1 part of tryptophan, 1 part of methionine, 0.5 parts of tetrahydromethyl pyrimidine carboxylic acid, 5 parts of nicotinamide, hydroxyethyl 5 parts of urea, 3 parts of trehalose, 3 parts of pullulan, 3 parts of mannitol, and the balance is deionized water.

[0044] Present embodiment also provides a kind of preparation method of freeze-dried collagen facial mask, comprises the steps:

[0045] (1) Pour deionized water into a stirring container, heat to 90°C, then cool down to 70°C;

[0046] (2) Weigh sodium hyaluronate, betaine and hydroxyethyl cellulose according to the above mass ratio, add them into a stirring container, an...

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Abstract

The invention provides a lyophilized collagen mask. The lyophilized collagen mask is prepared from recombinant human-derived collagen, sodium hyaluronate, betaine, hydroxyethyl cellulose, a first nutrient, a second nutrient, a third nutrient, a lyophilizing adjuvant and deionized water. By reasonably proportioning collagen, nutrient substances and other components, the lyophilized collagen refreshing mask which is convenient to store, not easy to deteriorate, high in activity and easy to use can be prepared and can be used immediately after being dissolved, so that the safety of the raw materials can be kept, and the use convenience is improved. Hydroxyethylurea, tetrahydromethylpyrimidine carboxylic acid and nicotinamide are added into the formula, so that the stable state of human skin can be maintained, the epidermal repair speed is accelerated, and wound healing is promoted. Compared with the formula in the prior art, the product has the advantages of high safety, low irritation risk, rich composition, high effectiveness, high security, high bioactivity, good moisturizing effect, human body absorption improvement, epidermal repair speed acceleration and wound healing promotion.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to a freeze-dried collagen facial mask and a preparation method thereof. Background technique [0002] The common form of collagen mask is usually made in a wet method. The non-woven or elastic mask paper is soaked in the essence with beauty ingredients, and then sealed and packaged into a small package that can be carried around. When using it, take out the mask that is full of essence. Apply to face. However, the preservation of wet facial masks is not easy. Since the ingredients of the essence are mostly high-nutrient substances, the humid environment with high water activity can easily promote the growth of bacteria or mold. The storage period is short, and antimicrobial agents such as parabens must be added. Preserved with high-grade preservatives, it is easy to cause allergies, and then cause the suspicion of contact dermatitis, causing damage to users. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/44A61K8/42A61K8/49A61K8/67A61K8/65A61K8/60A61K8/34A61K8/02A61Q19/00
CPCA61K8/735A61K8/44A61K8/42A61K8/731A61K8/4953A61K8/675A61K8/65A61K8/60A61K8/73A61K8/345A61K8/673A61K8/447A61K8/492A61K8/0212A61Q19/00A61K2800/592A61K2800/52A61K2800/84A61K2800/85
Inventor 卢敏
Owner 西安博和医疗科技有限公司
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