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Oil adjuvant of inactivated vaccine

An inactivated vaccine and oil adjuvant technology, which is applied to medical preparations containing active ingredients, antibody medical ingredients, refining to remove heteroatoms, etc., can solve the problem of poor performance stability of white oil injections, unstable vaccine performance, and fragile Dairy product performance and other issues, to achieve the effect of reducing vaccine cost, small resistance, and single component

Active Publication Date: 2009-07-08
兆丰华生物科技(南京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the number of carbon atoms is too small, the viscosity of the oil is too low, it is easy to break the emulsion during the vaccine preparation process and make the product performance unstable, so the carbon number distribution must be more reasonable
[0006] At present, the general production and production of injection white oil in our country is made by acid-base or deep hydrogenation of lubricating oil base oil with corresponding viscosity. At present, lubricating oil base oil is basically blended according to certain physical properties such as viscosity and flash point. Therefore, the performance stability of the injection white oil prepared by it is poor, and the performance of the vaccine produced is also unstable.

Method used

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  • Oil adjuvant of inactivated vaccine
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  • Oil adjuvant of inactivated vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] One, first prepare mannitol oleate

[0024] Take 40g of mannitol under the protection of nitrogen, and dehydrate at 195°C for 0.50 hours, then slowly add 80g of oleic acid and 0.20g of sodium hydroxide NaOH, which are equivalent to 2.0 times and 1 / 200 times the weight of 40g of mannitol, respectively, and keep the temperature constant Fatification 3 hours, obtain the emulsifier of mannitol oleate, the structural formula of this mannitol oleate is:

[0025]

[0026] 2. Preparation of white oil for injection

[0027] 1. Preparation of raw materials

[0028] The paraffin base is distilled by a distillation method, and the distilled fraction at 270-320° C. is used as the white oil raw material for injection.

[0029] 2. Remove impurities from raw materials

[0030] The hydrogen and white oil raw materials are simultaneously fed into the hydrogenation reactor at a volume ratio of 500 to carry out the first-stage hydrogenation reaction. The hydrogen passes through the r...

Embodiment 2

[0043] One, first prepare mannitol oleate

[0044]Also get 40g mannitol under the protection of nitrogen, dehydrate under the condition of 190 ℃ for 0.40 hours, then slowly add 60g oleic acid and 0.18g sodium hydroxide NaOH which are equivalent to 1.5 times and 1 / 220 times of the weight of 40g mannitol respectively, Constant temperature lipidation for 2.5 hours, the emulsifier of mannitol oleic acid was obtained, the structural formula of this mannitol oleic acid was the same as the above-mentioned embodiment.

[0045] 2. Preparation of white oil for injection

[0046] 1. Preparation of raw materials

[0047] The intermediate crude oil base is distilled by distillation method, and the distilled fraction at 279-312° C. is used as the white oil raw material for injection.

[0048] 2. Remove impurities from raw materials

[0049] The hydrogen and white oil raw materials are simultaneously fed into the hydrogenation reactor at a volume ratio of 750 to carry out the first-stage ...

Embodiment 3

[0062] One, first prepare mannitol oleate

[0063] Take 40g mannitol in the same nitrogen or take 40g mannitol under nitrogen protection, dehydrate under the condition of 200 ℃ for 0.60 hours, then slowly add 100g oleic acid and 0.22g sodium hydroxide NaOH, constant temperature lipidation 3.5 hours, obtain the emulsifier of mannitol oleate, the structural formula of this mannitol oleate is identical with embodiment 1.

[0064] 2. Preparation of white oil for injection

[0065] 1. Preparation of raw materials

[0066] The paraffin-based oil is distilled by distillation, and the distilled fraction at 270-320°C is used as the raw material for white oil for injection.

[0067] 2. Remove impurities from raw materials

[0068] The hydrogen and white oil raw materials are simultaneously fed into the hydrogenation reactor at a volume ratio of 1000 to carry out the first-stage hydrogenation reaction. The hydrogen passes through the reaction bed in the hydrogen reactor and is separat...

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Abstract

The invention relates to an oil adjuvant of inactivated vaccine. The oil adjuvant consists of white oil for injection and mannitol olein which are mixed in volume proportion of 90:10 to 100:8. The oil adjuvant of the inactivated vaccine has the advantages that: 1) the oil adjuvant of the inactivated vaccine is convenient for use, the process for manufacturing the inactivated vaccine is simplified, the inactivated vaccine is manufactured by one step in stead of three steps at present, and the cost of the vaccine is reduced; 2) the oil adjuvant of the inactivated vaccine is almost nontoxic, the content of aromatic hydrocarbon of the white oil used in the invention is low and is less than 50ppm, after the vaccine is injected into an animal body, the vaccine causes very small erythema and does not influence the quality and the appearance of meat; and 3) the oil adjuvant of the inactivated vaccine has low viscosity coefficient, has low resistance for pushing a pin when being used for animal epidemic prevention injection and is convenient for injecting.

Description

technical field [0001] The invention relates to intermediate preparations for animal inactivated vaccines, in particular to oil adjuvants for inactivated vaccines. Background technique [0002] At present, the production process of inactivated vaccines generally requires three steps: the first step is to mix the white oil for injection and the oil-soluble emulsifier evenly, the second step is to mix the antigen solution and the water-soluble emulsifier evenly, and the third step is to mix the above two steps evenly The solutions are put together for emulsification to prepare a uniform and stable water-in-oil inactivated vaccine. The method is complicated in process, long in process, high in energy consumption and low in production efficiency. The main reason is that oil-soluble emulsifiers are insoluble in water, and water-soluble emulsifiers are insoluble in oil, so the emulsification process must be completed in three steps. Both oil-soluble and water-soluble emulsifiers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39C10G45/02C07D307/12
Inventor 陈锡武刘卫星薛家兵
Owner 兆丰华生物科技(南京)有限公司
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