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Medical dust cloud agent or granular agent and its use

A powder spray and analgesic technology, which is applied in the field of medical preparations, can solve problems such as unreported applications, and achieve the effects of convenient use, remarkable wound repair and healing, and stable quality.

Active Publication Date: 2007-01-24
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports on powder sprays and granules made of chitosan derivatives as main components and their applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Preparation of medical powder spray A: Weigh 20g of carboxymethyl chitin powder and 10g of carboxymethyl cellulose powder, put them in a 10L stainless steel bucket, add 3L of distilled water and stir until completely dissolved, then slowly stir at 800rpm. Add 95% aqueous ethanol until the mixture of carboxymethyl chitin and carboxymethyl cellulose is dehydrated in the solution to form a uniform emulsion suspension, continue to stir for 30 minutes, place the precipitate, remove the supernatant, and filter the precipitate with suction to obtain solids. The solid was then dehydrated three times with absolute ethanol, filtered with suction, and dried in vacuum to obtain a fine powder solid. The fine powder of the solid is sieved through 500 meshes, and the prepared fine powder is packed in an aluminum foil bag. 60 Co irradiation sterilization, get medical powder A.

[0011] In this embodiment, the weight ratio range of carboxymethyl chitin to carboxymethyl cellulose is 10...

Embodiment 2

[0013] Preparation of medical powder spray B: Weigh 30 g of hydroxypropyl chitosan powder, put it in a solid pulverizer, add 3 mg of anti-inflammatory analgesic diphenhydramine hydrochloride, pulverize it into fine powder at high speed, and then grind the fine powder into 200 mesh Sieve, pack the fine powder passing through 200 meshes in an aluminum foil bag, and sterilize with ethylene oxide to obtain medical powder aerosol B.

[0014] The weight ratio scope of the hydroxypropyl chitosan described in the present embodiment and the anti-inflammatory analgesic diphenhydramine hydrochloride is 100: 0.001~10; Hydroxypropyl chitosan can use the following chitin derivatives instead One: carboxymethyl chitosan, carboxymethyl chitin, hydroxypropyl chitin, succinyl chitosan, succinyl chitin; anti-inflammatory analgesic diphenhydramine can also be other anti-inflammatory analgesic: Amitriptyline, ketoserin, promethazine, ibuprofen, indomethacin, and other known drugs with anti-inflamma...

Embodiment 3

[0017] Adhesion prevention effect test of medical powder aerosol and medical powder aerosol B:

[0018] 30 female Wistar rats weighing 200±20 g were selected and randomly divided into 3 groups, 10 rats in each group. The three groups are: blank control test group, powder spray A test group, powder spray B test group. All animals were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 30 mg / Kg. Take an incision about 3 cm in the middle of the abdomen, open the abdominal cavity, find out the cecum under aseptic conditions, squeeze out the contents from the end of the cecum, and rub the surface of the cecum with sterile gauze until the outer layer of the serosa is damaged. There is beaded bleeding on the surface of the cecum. Each group was treated as follows: (1) blank control group: put the bruised cecum back into the abdominal cavity directly, and suture the incision; (2) powder aerosol A test group: uniformly put Sprinkle 0.1g of medical powder ...

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PUM

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Abstract

The medical atomized agent consists of chitin derivative and macromolecular isolator in the weight ratio of 100 to 0.1-99.9; or consists of chitin derivative and anti-phlogistic anodyne or spasm inhibitor in the weight ratio of 100 to 0.001-10. The medical atomized agent is used in surgical operation for preventing tissue adhesion and relieving pain and in clinical treatment for promoting wound healing and relieving pain.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a medical powder or granule and its application. Background technique [0002] Postoperative interstitial adhesion is a common complication in abdominal surgery, gynecology, orthopedics, and cardiothoracic surgery, and the incidence rate can be as high as 90%. Postoperative adhesions can lead to different degrees of clinical symptoms, such as abdominal pain, pelvic pain, intestinal obstruction, infertility, etc., causing great pain to patients. Therefore, preventing postoperative interstitial adhesions is an urgent problem to be solved. At present, there are two main clinical measures to prevent postoperative adhesions: one is to use drugs for adjuvant therapy, such as antibiotics, anti-inflammatory drugs, anticoagulants, etc. Not ideal, and some drugs have obvious side effects; the second is to use spacers, such as colloidal solutions of hyaluronic acid, dextran, sodium carboxymethylcel...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/722A61K45/00A61K47/38A61K47/36A61P41/00A61P17/02
Inventor 顾其胜刘万顺韩宝芹
Owner 青岛博益特生物材料股份有限公司
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