483 results about "Berberine hydrochloride" patented technology

The invention discloses a probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as a preparation method and application of the composition. The probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar is prepared from extracts of the following traditional Chinese medicines: compound arrowroot, yam, mulberry leaf, medlar, purslane, dry ginger, tartary buckwheat, American ginseng, liquorice, silkworm chrysalis and porcine pancreas, which are taken as a fermentation substrate through probiotic fermentation. The probiotic fermented traditional Chinese medicinal compound composition can be used for preparing medicines or healthcare food or food for treating diabetes. The probiotic fermented traditional Chinese medicinal compound composition has easily acceptable taste and has no irritation to gastrointestinal tract; meanwhile, the probiotic fermented traditional Chinese medicinal compound composition, due to the probiotic bacterium as well as a metabolic product thereof, can condition a gastrointestinal environment, enhance absorption to medicines, and relieve irritation of berberine hydrochloride on the gastrointestinal tract.

The invention discloses preparation and quality detection method of compound prescription cortex phellodendri chinensis fluid. The quality detection method comprises the identification of forsythia fruit, cortex phellodendri, honeysuckle and dandehon herb, the checking of lonicerae flos, and the content determination of forsythin and berberine hydrochloride. According to the determination method, spots with the same colors are formed in a qualified test article thin-layer chromatogram and in corresponding positions of a reference substance thin-layer chromatogram, and negative control is interference-free, and the method is good in selectivity, simple and accurate. The checking method of lonicerae flos adopts a high performance liquid chromatography, is good in specificity, and can distinguish the situation that lonicerae flos is adopted in the compound prescription cortex phellodendri chinensis fluid to pretend honeysuckle flower to charge material. The content determination of forsythin and berberine hydrochloride is good in linear relation and high in recovery test accurancy, has good repeatability and stability, can accurately and strictly detect the quality of the compound prescription cortex phellodendri chinensis fluid, and guarantees a high quality standard level of the compound prescription cortex phellodendri chinensis fluid.

The invention relates to a preparation method of berberine hydrochloride which is a broad spectrum antibiotic. The method takes 2, 3-dimethoxy benzyl alcohol and homopiperony lamine as raw materials to prepare the berberine hydrochloride by six steps of reaction, namely, alkylation, chloromethylation, cyanidation, alcoholysis, condensation and cyclization. The synthetic technology has easily available materials, high yield but low cost, thus being suitable for industrial production.

The invention discloses a synthetic process of berberine. The synthetic process comprises the following synthetic route: pyrocatechol and dichloromethane are taken as raw materials and dimethyl sulphoxide is taken as a solvent to synthesize 1,3-benzodioxole; 1,3-benzodioxole is subjected to ViLsmeiar formylation to synthesize heliotropin; heliotropin undergoes nitration through a Henry reaction to generate beta-nitro-3,4-dioxomethenyl styrene; beta-nitro-3,4-dioxomethenyl styrene is subjected to Clemmensen reduction to generate 3,4-(methylenedioxyphenyl)ethylamine; and 3,4-(methylenedioxyphenyl)ethylamine and 2,3-dimethoxy benzaldehyde condense, and the obtained product is reduced to generate N-2,3-dimethoxybenzyl [3,4-(methylenedioxy)phenyl]ethylamine hydrochloride. N-2,3-dimethoxybenzyl [3,4-(methylenedioxy)phenyl]ethylamine hydrochloride is cyclized in a condition of glyoxal, formic acid and copper sulphate to generate berberine hydrochloride. According to the synthetic route, cyanation is avoided and toxicity is reduced. Zinc amalgam is adopted to replace H2Ni and LiAlH4, so that the cost is greatly reduced, the process difficulty is reduced, and the product yield is increased.

The invention relates to a quality detecting method for a traditional Chinese medicine compound preparation, in particular to a quality detecting method for a traditional Chinese medicine composition for treating hematuresis. According to the technical scheme, the quality detecting method for the traditional Chinese medicine composition for treating hematuresis is prepared from cortex phellodendri, lalang grass rhizome, clerodendranthus spicatus and linarin in herba cepbalanoplosis segeti. The invention further provides a method for detecting the content of berberine hydrochloride in cortex phellodendri and the content of rosmarinic acid in clerodendranthus spicatus. High performance liquid chromatography is adopted. According to the method, lalang grass rhizome, cortex phellodendri, clerodendranthus spicatus and herba cepbalanoplosis segeti in the traditional Chinese medicine composition for treating hematuresis are qualitatively detected through thin-layer chromatography, and the method is simple and stable. The high performance liquid chromatography is used for detecting the content of berberine hydrochloride in cortex phellodendri and the content of rosmarinic acid in clerodendranthus spicatus, the method is easy and convenient and high in repeatability and stability, the result is accurate, the method serves as a method for detecting the content of ingredients of the traditional Chinese medicine compound preparation, and the rationality and reliability of the whole quality control method are enhanced.

The present invention discloses one kind of nanometer berberine hydrochloride emulsion. The nanometer berberine hydrochloride emulsion consists of berberine hydrochloride 0.1-2 wt%, surfactant 20-40 wt%, co-surfactant 10-20 wt%, solvent 1-10 wt%, oil phase 5-30 wt%, sweetener 1-5 wt% and distilled water 27.5-70 wt%. The nanometer berberine hydrochloride emulsion has raised berberine hydrochloride dissolubility, raised bioavailability, lowered toxic side effect, simple preparation process and low production cost.

A method for preparing a macrocyclic lipidosome of berberine hydrochloride with ammonium sulphate gradient method-thin film evaporation method is provided, which comprises: 1) dissolve egg yolk lecithin, cholesterin with 1/3 egg yolk lecithin quality, polyethyleneglycol 2000 with 1/20 to 1/5 egg yolk lecithin quality; 2) decompress the recycled ethanol to form a film on vessel wall; infuse ammonium sulphate solution to dissolve the film material; hydrate for 1h to 2h; 3) take distilled water as dialysis medium to dialyse for 15 to 20h, make ammonium sulphate gradient to get blank lipidosome; 4) add berberine hydrochloride solution into the blank lipidosome; 5) incubate under the temperature of 30 to 60 degree for 10 to 60 minutes; 6) take the solution after inculation, dialyse it under different temperatures for 12h with distilled water as dialysis medium, get colorless and transparent fluid. Transfer and define constant volume of the dialysis fluid to get macrocyclic lipidosome with high encapsulation rate, excellent stability and even grain diameter. The macrocyclic lipidosome prepared in the invention has the advantages of high encapsulation rate, excellent stability and even grain diameter.

The invention discloses a berberine hydrochloride solid lipid nano preparation and a preparation method thereof, relates to berberine hydrochloride, and provides the berberine hydrochloride solid lipid nano preparation which has the advantages of simple method, low production cost, convenience in carrying and transportation and suitability for any administration route and the preparation method thereof. The berberine hydrochloride solid lipid nano preparation comprises the following raw materials in percentage by mass: 1 percent of berberine hydrochloride, 5-15 percent of solid lipid, 5-15 percent of emulsifier and 1-3 percent of surfactant. The solid lipid and the emulsifier are added into an organic solvent; after the solid lipid is fully dissolved, the berberine hydrochloride is added and is dissolved to obtain an oil phase; the obtained oil phase is added into a water phase containing the surfactant and is stirred until the organic solvent is fully removed; the obtained material is subjected to ultrasonography, is cooled and then is filtered by using a micro-porous filter membrane to obtain berberine hydrochloride solid lipid nanoparticle suspension; and the obtained berberine hydrochloride solid lipid nanoparticle suspension is added into a free-dry protecting agent to be freeze-dried to obtain the berberine hydrochloride solid lipid nano preparation which is in the form of nanoparticle freeze-dried powder.

The invention discloses a natural feed additive and a preparation method thereof. The additive is prepared by taking berberine hydrochloride and astragalus polyose as raw materials and combining the raw materials according to a proper proportion. The natural feed additive has the advantages of having the capability of improving the immunity and disease resistance of animals, promoting the growth and development of the animals and increasing the productivity.

The invention provides a preparation method of a traditional Chinese medicine for treating kidney failure, which comprises the following steps of preparing traditional Chinese medicinal raw materials, including radix pseudostellariae, rheum officinale, rhizoma coptidis, poria cocos, rhizoma pinellinae praeparata, radix salviae miltiorrhizae, 80 to 120 parts of dried orange peel, safflower, radix achyranthis bidentatae and liquorice, preparing rheum officinale powder, preparing radix pseudostellariae powder, preparing thick paste and obtaining the preparation. The invention also provides a quality inspection method of the traditional Chinese medicine, which comprises the following steps of checking according to each rule under a granule item of a pharmacopoeia, and content determination according to high performance liquid chromatography, and the rhizoma coptidis content of each granule of the traditional Chinese medicine cannot be less than 15.0mg by berberine hydrochloride C20H17NO4.HCl. The preparation process provided by the invention is reasonable in design, is advanced, and has the advantages that the characteristic of coldness of the existing medicine Shenshuaining can be effectively improved, the dissolving-out amounts of effective components of the rheum officinale and the radix pseudostellariae and the extraction rate are increased, effective components of a product are completely saved, and besides, the problems of instability and uncontrollability of the effective components of the rheum officinale and the radix pseudostellariae in the medicine are also effectively improved. The quality inspection method provided by the invention has the advantages that the stability and the controllability of the quality of the medicine Shenshuaining can be guaranteed.

The invention discloses non-toxic colored plasticine. The non-toxic colored plasticine contains the following ingredients: wheat flour, glutinous rice flour, plant protein powder, starch, carrageenan, clay, maltose, refined salt, edible oil, berberine hydrochloride, a humectant, vitamin E, potassium sorbate and water. The invention further discloses a corresponding preparation method of the non-toxic colored plasticine. According to the non-toxic colored plasticine and the preparation method thereof, the formula is reasonable, and natural raw materials are adopted, so that the non-toxic colored plasticine is non-toxic, odorless, environmentally friendly and pollution-free, is high in plasticity, good in toughness and bright-colored in color and does not stick hands; children are prevented from mistakenly eating the plasticine, and the safety is guaranteed.

The invention relates to a plant extract composition, a preparation method thereof and application of the plant extract composition in preparing the antifungal products. The composition comprises one or more components of matrine extract, scutelloside extract, berberine hydrochloride extract, agrimophol extract, caffeic acid extract and asiaticosid extract. The antifungal products comprise antidandruff shampoo, mouth cleaning products, female sanitary products, itching-relieving shower bath and antifungal medicaments. The invention also relates to an antifungal product using the composition.

The invention discloses a berberine hydrochloride medicinal composition and a preparation method thereof, which are used for increasing the dissolution rate of berberine hydrochloride in water and enhance the in-vivo absorption of berberine hydrochloride. According to the specific technical scheme, berberine hydrochloride serves as a medicinal active ingredient of the composition; and a filling agent, a disintegrating agent, a flavoring agent and a lubricating agent in the weight ratio (1-50):(25-60):(3-15):(1.5-3):(0.4-1.2) serve as auxiliary materials. The method for preparing the berberine hydrochloride medicinal composition comprises the following steps of: (1) dissolving; (2) drying; (3) screening; and (4) tableting. The berberine hydrochloride medicinal composition prepared with the method has high disintegrating and dissolving speeds and a good medicament effect, and the problems of low solubility and unstable absorption of berberine hydrochloride are solved. The berberine hydrochloride medicinal composition is effective to enteral infection caused by dysentery bacillus and colon bacillus, and is used for treating enteral infection and diarrhea.

The invention discloses an anti-releasing compound flexible liposome with positive charges and a preparation method thereof. The anti-releasing compound flexible liposome is prepared from the following components in parts by weight: 0.1-10 parts of linoleic acid, 5-30 parts of berberine hydrochloride, 5-30 parts of glycyrrhizic acid, 2-15 parts of glutathione, 0.01-5 parts of phytosphingosine, 1-40 parts of matrine and 1-25 parts of tea polyphenols. By researching a multi-target formula which has a clear mechanism and aims at androgenetic alopecia, an anti-hair loss composition is obtained; and the composition is prepared into the compound liposome with the positive charges, so that the flexible application of the composition on a preparation is improved, and adsorption of the preparation on scalps and deep osmosis of the preparation into hair follicles are promoted. The multi-target compounding effect of the preparation can effectively inhibit further development of hair loss, and the growth of new hairs is promoted.

The invention discloses a preparation method of a berberine hydrochloride tablet, and the preparation method is applied to the field of pharmaceutical preparation. The berberine hydrochloride tablet consists of a tablet core and a coating material, wherein the tablet core consists of berberine hydrochloride and auxiliary materials, each tablet contains 300mg of the berberine hydrochloride, and the auxiliary materials contains one or a plurality of a filling agent, a disintegrating agent, a lubricant, a surfactant and a wetting agent; a coating layer consists of the coating material and water; the coating layer further contains a plasticizer or an antiadherent, wherein the filling agent contains one or a random composition of starch, lactose, pregelatinized starch and microcrystalline cellulose; the disintegrating agent contains one or a random composition of crosslinking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, sodium carboxymethyl starch, hydroxypropyl starch and low-substitution hydroxyl propyl cellulose; and the lubricant contains one or a random composition of aerosol, talc powder and magnesium stearate. The method is suitable for the large-scale and long-time production of production departments, and has the advantages of stable technology, no dependence on tablet machines, good particle liquidity and formation, controllable tablet weight difference, stable quality, high tablet core hardness, difficulty in wearing and coating suitability.

The invention relates to a berberine hydrochloride compound preparation made from the following components in terms of weight percentage: 0.5-1% of berberine hydrochloride, 2-5% of antibacterial medicament, 0-0.1% of antiviral medicament, 1-1.5% of antibacterial synergist, 0-15% of stabilizer, 0-30% of cosolvent, 0-5% of local anodyne, 0-2% of antioxidant and balance of disperse medium. The inventive compound preparation has the following advantages: (1) the compound preparation solves the instability problem of berberine injection by making the berberine into orally taken liquid; (2) the berberine hydrochloride when used with enrofloxacin and TMP together can be used as the preferable medicament for intestinal infections, is more advantageous in treating intestinal infections caused by escherichia coli and salmonella than other single antibiotics sold in the market, especially good for drug resistant strains, is applied two times a day for three constant days, and prevention and treatment rate is up to 100%; (3) the berberine hydrochloride when used with enrofloxacin, gentamicin sulphate and TMP together is used to treat septicaemia, respiratory tract infections and intestinal infections caused by sensitive bacteria.

The invention discloses a preparation method of an alpha-glycosidase inhibitor 2,3,4-trihydroxy benzaldehyde-9'-O-berberine acylhydrazone, and can be used for preparing the medicines to treat diabetes. A structural formula of a compound is shown in the description. The preparation method comprises the following steps: 1) taking berberine hydrochloride as an initial raw material, demethylating under pressure reduction 190 DEG C condition, wherein the products can not be separated to obtain berberrubine (I), bridging the obtained compound I and alpha-ethyl bromoacetate through a nucleophilic substitution reaction to form a berberine ethyl acetate derivative (II); 2) performing hydrazinolysis of the compound II and hydrazine hydrate to obtain berberine hydrazides (III); and 3) performing nucleophilic addition-dehydration reaction on the compound III and the 2,3,4-trihydroxy benzaldehyde to obtain the 2,3,4-trihydroxy benzaldehyde-9'-O-berberine acylhydrazone (TM), and purifying the products through a recrystallization method. The 2,3,4-trihydroxy benzaldehyde-9'-O-berberine acylhydrazone has strong alpha-glucosidase inhibition activity through alpha-glucosidase inhibition experiment, and its inhibition performance is higher than that of a comparison product acarbose by 1.2 times.

A microsoftgel of berberine hydrochloride is prepared from the berberine hydrochloride and acrylic resin through dissolving acrylic resin in acetone, adding berberine hydrochloride and antisticking agent, dispersing, stirring, adding it to atoleine, heating for removing acetone, washing by hexane and drying.

A quality test method for the Chinese medicine used to treat ophthalmopathy, myopia and eye strain features that a qualitative discrimination is used for paeonol, chrysophanol, emodin, ararobinol, paeoniflorin, danshensu sodium and icariin, and a high-effect liquid-phase chlomatography is used to test the content of berberine hydrochloride.

The invention relates to a quality detection method for Jinhuaxiaocuo pills (WS3-B-2169-96) in the eleventh volume of Drug Standard of Ministry of Public Health of the Peoples Republic of China (Chinese patent medicaments). Through the quality detection method for the Jinhuaxiaocuo pills, the quality control standard for the Jinhuaxiaocuo pills is improved, a method for detecting the content of a main ingredient in a preparation is established, physical and chemical reaction identification with poor specificity is eliminated, and thin layer chromatography identification methods for geniposide and berberine hydrochloride are improved to have the advantages of simplness and clear characteristic spots, thin layer chromatography identification methods for rhubarb, golden thread, amur corktree bark and baical skullcap root in the Jinhuaxiaocuo pills are increased, and the high quality standard level of the compound preparation is guaranteed.