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Probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as preparation method and application of composition

The technology of probiotic bacteria and composition is applied to the probiotic fermented traditional Chinese medicine compound composition for assisting hypoglycemia and the fields of preparation and application thereof, which can solve the problems of long-term use, lack of coordination, side effects, etc. Gastrointestinal function, easy to accept mouthfeel, increase absorption effect

Active Publication Date: 2014-02-05
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine has strong hypoglycemic effect and quick onset. However, it often lacks overall coordination and has obvious side effects, which is not conducive to long-term use by diabetic patients.

Method used

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  • Probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as preparation method and application of composition
  • Probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as preparation method and application of composition
  • Probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Probiotics fermented Chinese medicine compound composition method in the composition of composite compositions

[0029] Take 24g of silkworm pupae, dry the washed silkworm pupa at 100 ° C until the moisture is less than 5.0%, crushed, over 40 mesh sieves, add 95%ethanol (weight / volume) of 3 times the pupa powder, 60 ° C for 2.0 hours, pump up, smokeAfter filtering, dry at 80 ° C and over 40 measuring sieves. Disastersed silkworm pupa powder. Add 6 times water (weight / volume) to the abandoned silkworm pupa powder, soak for 30 minutes, heat and boil for 30 minutes, and cool to 45 ° C for later use.This is a lipstick liquid.Take 60g of fresh pork pancreas, remove the fat tendons, mix with abandoned silkworm pupa powder after beating, use sodium hydroxide to adjust the pH value of 8.0, enzymes disintegrate for about 3 hours, and pH drop to 6.5-6.8End the enzymatic disintegration.The pH value of the enzyme disintegration is 4.5 with hydrochloric acid, and heated to bo...

Embodiment 2

[0030] Example 2 Probiotics Fermentation of Chinese Medicine Compound Composition Preparation

[0031] Crush the western ginseng, go over 100 measuring sieves, get western ginseng powder; according to the following weights, we can take various traditional Chinese medicines: Pink Ge 80g, yam 40g, mulberry leaves 40g, 40g of wolfberry, purslane 60g, dry ginger 25g, 100g of bitter buckwheat, 100g, 100g of bitter buckwheats, 100g of bitter buckwheat,Western ginseng 50g (fine powder), 8g of licorice, soak 8 times water for 1 hour, and extract for 1 hour at 100 ° C, filtrate, add 6 times water to the filter slag, extract for 1 hour to 100 ° C, filter and combine the filter liquid.And add the solution of the silkworm pupa enzymes extracted in the Example 1, and condensed to 1000ml under the decompression, which gets the Chinese medicine compound extract.Then add glucose (weight / volume ratio 0.5%), protein cymbal (weight / volume ratio 0.2%), yeast powder (weight / volume ratio 0.1%), yeast p...

experiment example 1

[0035] Experimental Example 1: The compound composition of the Chinese medicine compound composition of the present invention assists blood sugar and sugar tolerance experiments

[0036] The examples of this embodiment are designed to use the high blood sugar model of rats to describe the effect of preparation of poipher fermented Chinese medicine compound compositions to reduce blood sugar effects according to the method of the invention.

[0037] Emptor blood sugar experiment: Take the compound compound composition of the Chinese medicine and hydrochloric acid (Qingdao Huanghai Pharmaceutical Co., Ltd.) prepared by Practice Example 2 as a sample for testing.Johnson & Johnson Globe measurement instrument measures blood glucose value.

[0038] 80 male rats with 180 ± 20g, adaptive breeding for 3 days, randomly remove 10 separate feeding, for blank control group, and the remaining 70 inject chain diapers in the dose of 60 mg / kg.To determine the empty blood glucose, if it is lower t...

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Abstract

The invention discloses a probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as a preparation method and application of the composition. The probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar is prepared from extracts of the following traditional Chinese medicines: compound arrowroot, yam, mulberry leaf, medlar, purslane, dry ginger, tartary buckwheat, American ginseng, liquorice, silkworm chrysalis and porcine pancreas, which are taken as a fermentation substrate through probiotic fermentation. The probiotic fermented traditional Chinese medicinal compound composition can be used for preparing medicines or healthcare food or food for treating diabetes. The probiotic fermented traditional Chinese medicinal compound composition has easily acceptable taste and has no irritation to gastrointestinal tract; meanwhile, the probiotic fermented traditional Chinese medicinal compound composition, due to the probiotic bacterium as well as a metabolic product thereof, can condition a gastrointestinal environment, enhance absorption to medicines, and relieve irritation of berberine hydrochloride on the gastrointestinal tract.

Description

Technical field [0001] The present invention involves probiotic fermentation Chinese medicine extracts and preparation methods, which further involves the scriptures of powderThe fermentation compositions made after the fermentation of intestinal probiotics, and the application of the fermentation composition in preparation to reduce the application of food, health products, and medicines in patients with hypertension, which belongs to the field of biological fermentation technology. Background technique [0002] Diabetes Mellitus (DM) is a common endocrine metabolic disease that belongs to the category of "thirsty disease" in traditional Chinese medicine.It is a set of metabolic diseases characterized by hyperglycemia in high blood sugar due to insulin secretion defects, or insulin defects, or both caused by both.The chronic hyperglycemia of diabetes should increase the increase in oxidation, causing long -term damage to multiple organs, dysfunction and failure, especially the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P3/10A23L1/29A61K35/64A61K35/39A61K35/74A23L33/00A61K35/745A61K35/747
Inventor 孙筱林褚新红吴炳新吕美李建龙
Owner SANZHU FUER PHARMA
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