804 results about "Cyanation" patented technology

The invention discloses a synthetic method for loxoprofen sodium, which is prepared by taking methyl acetophenone as an initial raw material through reduction, acylation or halogen substituent, cyanation, hydrolysis, bromination, condensation, decarboxylation and salifying. The method has the advantages of easily obtained raw material, unique technology, simple and stable operation, and high productive rate in each step of reaction; and all solvents used in the synthesis process can be recycled, so the production cost is reduced greatly. Tests show that the obtained product has reliable quality and stable performance, and can be further used for making preparation of non-steroidal anti-inflammatory drugs such as the loxoprofen sodium.

The invention provides a radiation-curable alkoxy silanized hyperbranched polyester acrylate, characterized in that the radiation-curable alkoxy silanized hyperbranched polyester acrylate is produced by using a hyperbranched molecule with at least 16 functionalities as a core; acrylating or methacrylating a portion of the terminal groups of the hyperbranched molecule; and terminating a portion of the end groups of the hyperbranched molecule with an isocyanated silane coupling agent. The acrylate of the invention can be formed into a coating on polar substrates, such as glass or metal, or used as an adhesive.

The invention provides a hydrocyanation process to produce adiponitrile and other dinitriles having six carbon atoms, in the presence of catalyst composition comprising a zero-valent nickel and at least one bidentate phosphorus-containing ligand wherein the bidentate phosphorus-containing ligand gives acceptable results according to at least one protocol of the 2-Pentenenitrile Hydrocyanation Test Method.

The invention provides a hydrocyanation process for the production of adiponitrile and other dinitriles having six carbon atoms, the process comprising:a) forming a reaction mixture in the presence of at least one Lewis acid, said reaction mixture comprising ethylenically unsaturated nitrites having five carbon atoms, hydrogen cyanide, and a catalyst precursor composition, by continuously feeding ethylenically unsaturated nitrites, hydrogen cyanide, and a catalyst precursor composition;b) controlling X and Z, wherein X is the overall feed molar ratio of 2-pentenenitriles to all unsaturated nitriles and Z is the overall feed molar ratio of hydrogen cyanide to all unsaturated nitrites, by selecting a value for X in the range from about 0.001 to about 0.5, and a value for Z in the range from about 0.5 / 1 to about 0.99 / 1, such that the value of quotient Q, whereinQ=X[(moles3PN+4PNinthefeed)(molesallunsaturatednitrilesinthefeed)]-Zis in the range from about 0.2 to about 10, wherein 3PN is 3-pentenenitriles and 4PN is 4-pentenenitrile; andc) withdrawing a reaction product mixture comprising adiponitrile;wherein the ratio of the concentration of 2-pentenenitriles to the concentration of 3-pentenenitriles in the reaction mixture is from about 0.2 / 1 to about 10 / 1;wherein the catalyst precursor composition comprises a zero-valent nickel and at least one bidentate phosphite ligand; andwherein the bidentate phosphite ligand is selected from a member of the group represented by Formulas I and 11 as described herein.

A hydrocyanation process produces adiponitrile and other dinitriles having six carbon atoms. The process involves forming a reaction mixture in the presence of at least one Lewis acid. The reaction mixture includes ethylenically unsaturated nitriles having five carbon atoms, hydrogen cyanide, and a catalyst precursor composition. The reaction mixture is continuously fed while controlling the overall feed molar ratio of 2-pentenenitriles to all unsaturated nitriles and the overall feed molar ratio of hydrogen cyanide to all unsaturated nitriles. In the reaction product mixture, including adiponitrile, the ratio of the concentration of 2-pentenenitriles to the concentration of 3-pentenenitriles is from about 0.2 / 1 to about 10 / 1. Included in the catalyst precursor composition is a zero-valent nickel and at least one bidentate phosphite ligand.

The invention relates to a manufacturing method of atorvastatin intermediate (R)-(-)-4-nitrile-3-hydroxybutyrate (ATS-5), which solves the problems of high cost, expensive raw material price and the like of the prior art. The manufacturing method is characterized in that the atorvastatin intermediate is prepared from epichlorohydrin as a raw material through ring-opening addition, glycolysis esterification, cyaniding substitution synthesis and refining. The invention has simple synthesis route, abundant raw material resources, low equipment requirements and no high-temperature high-pressure reaction; the content of produced ATS-5 is more than 98 percent, the content of water is lower than 0.2 percent, and the content of enantiomer is less than 1.0 percent. The manufacturing method is a mature production process for manufacturing the intermediate of medicine atorvastatin and is applicable to medium-sized and small enterprises.

The present invention is a new non-cyanide alkaline copper plating bath, preparation and use method thereof. In the copper plating bath, using copper sulfate or basic copper carbonate as main salt, using hydroxy-ethylidene diphosphonic acid as main complexant, using trisodium citrate, potassium citrate or potassium sodium tartrate as auxiliary complexant, using sodium nitrate or potassium nitrate as conductive salt, using sodium hydroxide or potassium hydrate as pH value regulator; the operation conditions are: cathode current density is 0.5-3.0 A / dm [2], pH of plating bath controlled between 12 and 13, plating bath temperature is 50-70 DEG. Comparing with the prior known technology, the invention has following advantages or positive effects: simple plating bath formula, easy control and operation, wide temperature range of plating bath using, high current efficiency, fine crystallization coating, good appearance color, stable plating bath, strong uniform plating and covering ability, low cost, easy wastewater treatment. The invention can be used for pre copper plating or direct electro-coppering instead of virulent cyaniding electro-coppering process.

The invention discloses a prolinol derivative induced chiral MOFs material with asymmetric catalysis, which belongs to the technical field of a chiral catalytic material. L-BCIP or D-BCIP is used as a chiral source; 5,5'-methylene diiso-phthalic acid, 4,4'-biphenyl acid, 3,3',4,4'-biphenyltetrazole acid or 4,4'-sulfonyl terephthalic acid is used as a connecting ligand; Ln3+ is used as a node; a three-dimensional hole channel structure is constructed by a hydrothermal method; the general formula is as follows: Ln<3+>+L+L-BCIP or D BCIP->Ln-L, wherein Ln<3+> is a rare earth metal ion; L is a connecting ligand; L-BCIP is L-N-tert-butoxycarbonyl-2-imidazole-1-pyrrolidine; and D-BCIP is D-N tert-butoxycarbonyl-2-imidazole-1-pyrrolidine. The material can be used as a heterogeneous catalyst used for an asymmetric silicon cyanation reaction; therefore, the catalyst can be recycled with a yield of 100% and ee value of 99%; and the chiral MOFs material has good application prospect in the aspects of synthesis of pure enantiomer compounds, synthesis of medical intermediates and the like. The material can be recycled after proper treatment.

These disclosures relate to preparing nickel metal (Ni(0)) suited for use in catalyst systems, such as nickel complexes with phosphorus-containing ligands, useful to catalyze the hydrocyanation of ethylenically unsaturated compounds. The methods described herein can include use of steam during reduction of nickel.

The invention discloses a diamine monomer containing a carbazole structure and having a high planarity, a synthetic method and an application thereof. In the method, the diamine is directly prepared from dihalogenated carbazole through ammoniation by liquid ammonia; or is directly prepared through a Suzuki reaction; or is directly prepared by performing cyanidation, hydrolysis and acylating chlorination to the dihalogenated carbazole to synthesize diacyl chlorocarbazole and then performing a reaction to the diacyl chlorocarbazole with a hydroxyl group or an amino group to form an ester bond or an amido bond; or is prepared by performing a Ullmann coupling reaction with the halogen atoms in the dihalogenated carbazole to form an ether bond, secondary amine or the like and finally reducing the dinitro group. The diamine synthetic process is simple, is simple in purification and is suitable for industrial production. A minimum energy state 3D molecular structure of the diamine monomer is high in planarity so that the diamine monomer can be used for preparing a high barrier polymer which is strong in interaction force among molecular chains and is small in free volume. The diamine monomer can be used for preparing high-performance and functionalized polyamides, polyimides, polyamideimides, polyesterimides and such polymers.

The invention provides a synthetic system of 3-cyanomethylbenzoic acid methyl ester and a method thereof. The system comprises an acylation reaction vessel used for preparation of m-Toluoyl chloride;a liquid chlorine feeding unit used for storing and conveying liquid chlorine; a chlorination reaction unit which is connected with the acylation reaction vessel and used as a chlorination reaction chamber of m-Toluoyl chloride; a micro-interface generator which is respectively connected with the liquid chlorine feeding unit and the chlorination reaction unit and used for receiving liquid chlorineconveyed by the liquid chlorine feeding unit, crushing the liquid chlorine into micro-droplets with the diameter being micron level and conveying the micro-droplets to the chlorination reaction unitafter the crushing; and an esterification and cyanation reaction unit which is connected with the chlorination reaction unit. In the prior art, m-Toluoyl chloride and liquid chlorine cannot be fully mixed when m-Toluoyl chloride and liquid chlorine react such that yield of 3-cyanomethylbenzoic acid methyl ester is reduced. The above problem is solved by the synthetic system and the method of the invention.

The invention belongs to the technical field of medicine, and relates to a method for synthesizing 2-(3-cyano-4-isobutoxy phenyl)-4-methyl-5-thiazole formic acid. The method comprises that: 4-hydroxyl cyanobenzene is used as a raw material, and subjected to iodination, hydrocarbylation and cyanation to obtain an intermediate of 4-isobutoxy-1,3-benzene dinitrile, the intermediate reacts with sodium bisulfide and anhydrous magnesium chloride to obtain a key intermediate of 3-cyano-4-isobutoxy phenyl thioformamide, and the 3-cyano group-4-isobutoxy phenyl thioformamide is subjected to cyclization and hydrolysis reaction to obtain the 2-(3-cyano-4-isobutoxy phenyl)-4-methyl-5-thiazole formic acid. The method has the advantages of easily obtained materials, simple and convenient operation, high yield, low cost and suitability for industrialized production.

The invention discloses a reinforced leaching method of fine-grained encapsulated gold, which comprises the following steps: adding cyanation slag, calcined pyrite, pyrite cinder, auriferous sulfide ore roasted product or any other auriferous material, a gold leaching agent, a pH regulator, an oxidizer, a dispersing agent and the like into a water-base solvent, carrying out ball milling leaching to obtain extra-fine ground leaching slurry, transferring the extra-fine ground leaching slurry into a high-pressure reaction kettle, supplementing the gold leaching agent, oxidizer and water-base solvent, introducing air or oxygen-enriched air, carrying out pressure leaching, filtering and separating to obtain an auriferous pregnant solution and leaching slag. The method is simple in and convenient to operate, and can implement high-efficiency leaching of the fine-grained encapsulated gold; the obtained pregnant solution can be subjected to the existing technique composed of activated carbon adsorption, desorption, electrolysis, zinc powder (wire) reduction and the like to recover gold; and the method has high applicability and obvious economic benefits.

The invention discloses a lead-zinc floating recycling method from gold ore cyanation tailings, which comprises the following steps: (1) predisposing: adding water in the cyanation tailings; stirring to form ore paste; adding active carbon, Y0 agent, FeSO4+ammonium persulphate in the ore paste; (2) asynchronous mixing-selecting: sending the predisposed ore paste to the floater group I to proceed first roughing separation; adding Y0 agent, limestone, butyl airpotato yam to float galena; sending the tailings in the first roughing separation to floater group II; adding Y0 agent, limestone, cupric sulfate, butyl airpotato yam to float zincblende; (3) recycling and purifying tailing water: adding chlorinated lime in the tailing water to decompose CN- less than 0.5 mg per L; recycling the tailing water.

The invention discloses a preparation method for a silver and graphene composite coating of a cyanide-free system. Due to the fact that common problems that cyanide silver plating pollution is serious, the human body will be harmed, and meanwhile a silver coating has some defects exist, the preparation method is characterized in that dispersed grapheme is added in the cyanide-free system, and composite plating is carried out on a copper substrate. The preparation method comprises the basic steps that (1) a substrate is subject to oil removing and polishing, and silver soaking treatment is carried out; (2) sodium thiosulfate, potassium metabisulfite and silver nitrate are prepared into silver plating liquid, graphene powder, a certain amount of deionized water and a certain number of dispersing agent are mixed to be added into the silver plating liquid, and ultrasonic dispersion is carried out; and (3) a silver plate serves as an anode, the substrate serves as a cathode, the silver plate and the substrate are placed into the silver plating liquid to be subject to electroplating, and the silver-graphene composite coating is obtained. Compared with the prior art, the method is simple in process, good in controllability and wide in application scope; and the prepared silver-graphene composite coating is good in resistance to high temperature oxidation, high in resistance to sulfur, high in mechanical property and high in resistance to corrosion.

The invention discloses a terpolymer containing polyester chain links and polycarbonate chain links and a synthetic method thereof. The synthetic method comprises the following steps: mixing zinc-cobalt double metal cyanide complex catalyst, cyclohexene oxide and dicarboxylic anhydride in a solvent, introducing CO2 under the temperature of 30 to 150 DEG C till the pressure of CO2 is 0.5 to 10.0MPa, carrying out copolyreaction for 0.5 to 48 hours so as to obtain a crude product, and preparing the terpolymer which contains polyester chain links and polycarbonate chain links and has excellent thermal property and easy decomposition after purification. The molar percentage content of the polyester chain links, the polycarbonate chain links and polyether chain links of the terpolymer containing polyester chain links and polycarbonate chain links in the main chain are respectively 5 to 70 percent, 23 to 90 percent and 0.5 to 7 percent.

The invention relates to a non-cyanide silvering brightener and a plating solution thereof. The non-cyanide silvering brightener uses water as solvent and comprises the following main components: 10-20g / L of sodium dodecyldibenzenesulphonate, 15-30g / L of beta-naphthol ethoxylate, 0.8-2g / L of hydroxyethyl ethylenediamine triacetic acid (HEDTA), 0.5-3g / L of potassium dihydrogen phosphate, 5-15g / L of urea, 3-18g / L of polyethylene glycol, 40-80g / L of sulfur-containing heterocyclic compound and 5-15g / L of nitrogen-containing carboxylic acid. The brightener of the invention does not contain cyanide, the mirror surface of the coating is bright, the same effect of cyanide-containing silvering can be realized; the performance tests of the coating show that the color of the coating obtained by using the non-cyanide bright silvering plating solution of the invention is difficult to change, and the coating has low brittleness and good adhesive force and can meet the requirements on coating in different application aspects.

The invention relates to a method and equipment for production of adiponitrile from adipic acid, and mainly solves the problem of unstable product quality in the prior art for production of adiponitrile from adipic acid. The method employs materials of fusing adipic acid, ammonia, phosphate and a diluent. The production method is as below: mixing phosphoric acid with the diluent in a pipeline mixer; conducting neutralization of adipic acid and ammonia in a cyanation reactor; sending reaction products into the bottom of a separation tower for separation; recovering gas phase of light components from an outlet; sending the diluent recovered by a gas lifting plate into the pipeline mixer, mixing the diluent with phosphoric acid in the pipeline mixer, and sending the mixture into the cyanation reactor to dilute adipic acid; and sending a liquid phase to a scraper type evaporator. The employed equipment includes an adipic acid storage tank, an ammonia compressor, a cyanation reactor, a pipeline mixer, a separation tower, a tail gas removal tower, a phosphoric acid storage tank and a scraper type evaporator. The invention has the advantage of a good quality of the produced adiponitrile product.

The invention relates to a preparation method of a fluorescent molecular probe for detecting fluoride ions in aqueous solutions through fluorescence enhancement and an application of the fluorescent molecular probe to detecting fluoride ions. The fluorescent molecular probe is prepared by protecting 1,4-diethyl-1,2,3,4-tetrahydro-7-hydroxyquinoxaline-6-aldehyde taken as a raw material with silane and then condensing the raw material and malononitrile. The fluorescent molecular probe is simple and convenient to synthesize, and reaction conditions are mild. The fluorescent molecular probe has the specific characteristics that the probe molecule has stable optical properties and higher synthetic yield; the probe molecule has high sensitivity of detection of fluoride ions in the aqueous solutions and low lower limit of detection, and the limit of detection is 5.4mu M; the response range is 0-1mM and the detection range is wide; the probe molecule has good selectivity and has no responses to anions, such as chloride ions, bromide ions, iodide ions, tetrabutylammonium cyanide, nitrates radicals, hydrosulfate radicals, perchlorate radicals, acetate radicals, thiocyanate radicals, azide radicals, cysteine, bovine serum albumin, carbonate radicals, sulfate radicals and reduced glutathione; the fluorescent molecular probe has practical application values in the fields of biochemistry, environmental sciences and the like.

The invention discloses a synthetic process of berberine. The synthetic process comprises the following synthetic route: pyrocatechol and dichloromethane are taken as raw materials and dimethyl sulphoxide is taken as a solvent to synthesize 1,3-benzodioxole; 1,3-benzodioxole is subjected to ViLsmeiar formylation to synthesize heliotropin; heliotropin undergoes nitration through a Henry reaction to generate beta-nitro-3,4-dioxomethenyl styrene; beta-nitro-3,4-dioxomethenyl styrene is subjected to Clemmensen reduction to generate 3,4-(methylenedioxyphenyl)ethylamine; and 3,4-(methylenedioxyphenyl)ethylamine and 2,3-dimethoxy benzaldehyde condense, and the obtained product is reduced to generate N-2,3-dimethoxybenzyl [3,4-(methylenedioxy)phenyl]ethylamine hydrochloride. N-2,3-dimethoxybenzyl [3,4-(methylenedioxy)phenyl]ethylamine hydrochloride is cyclized in a condition of glyoxal, formic acid and copper sulphate to generate berberine hydrochloride. According to the synthetic route, cyanation is avoided and toxicity is reduced. Zinc amalgam is adopted to replace H2Ni and LiAlH4, so that the cost is greatly reduced, the process difficulty is reduced, and the product yield is increased.

A process for synthesizing L-valine from n-butanol and acetone cyanohydrin includes cyanation reacting under action of alkaline catalyst to obtain butanol cyanohydrin, ammonifying reacting on liquid ammonia, deammonifying, dewatering to obtain aminopentylonitrile, hydrolyzing in concentrated sulfuric acid, neutralizing, extracting, concentrating to obtain dl-aminopentyl amide, splitting, recrystallizing, dissolving in water, ion exchanging by cationic exchange resin, eluting by ammonia water, decoloring, dewatering, rinsing and drying.

The invention relates to a method for preparing progesterone. According to the method, 4-androstenedione is used as raw materials, and hydroxyl cyanation, dehydration, protection, hydrogenation and addition hydrolysis reaction are carried out in sequence, and the progesterone is obtained. The 4-androstenedione which has the price advantage is used as the raw materials, the reaction condition is easy to control, post-processing is easy, and yield is high.

The invention relates to steel band continuous copper plating VI which adopts a cyanation copper plating technique to perform electroplating. The steel band continuous copper plating VI mainly comprises a pretreatment process and a copper electroplating process, wherein the pretreatment process mainly comprises the steps of ultrasonic oil removal, electrolytic oil removal, water washing, activating, water washing and the like; and the electroplating process mainly comprises the steps of copper plating, recycling, water washing and the like. A technical tank in the steel band continuous copper plating adopts a closed transparent simultaneous-gas-discharge isosceles trapezoid tank with openable view windows, wherein the upper part of the tank body is designed as an isosceles trapezoid; three transparent automatic-opening view windows are respectively designed at two slope parts of the tank; a plating solution in the plating tank in steel band continuous copper plating is circulated and filtered by double mother tanks; a pretreatment waste liquid and an electroplating waste liquid in the steel band continuous copper plating are circulated and filtered by three mother tanks, and sodium carbonate is treated on line; a funnel and a filter screen are arranged below a conducting roller for steel band continuous copper plating, and the residual plating solution on the steel band is recovered in an atomization spray mode; and a steel band outlet end of the steel band continuous copper plating is provided with a vacant tank which is about 100mm long, and the residual plating solution on the steel band is recovered in an atomization spray mode.

The invention discloses a gold extraction technique method for low-grade refractory gold ores. The method comprises the following steps: raw ores or cyanide tailings containing micro-fine particle sulfide-encapsulated gold are finely grinded; the finely grinded raw ores or cyanide tailings are added into an intense agitation inflation reaction device, and are mixed with water to form pulp; under an ordinary pressure at a temperature of 10 DEG C-100 DEG C, air or oxygen is introduced and mixing is performed so as to perform pre-oxidation; calcium oxide is added into the above mentioned pre-oxidized pulp to perform adequate alkali treatment; NaCN is added into the pulp subjected to alkali treatment for cyanide leaching, and finally, gold extraction is performed by using activated carbon for adsorption. The method disclosed by the invention has the advantages of low investment, low cost, simple equipment, mild conditions, high resource recovery rate and the like.

The invention discloses a preparation method for long carbon chain nylon PA1313. The preparation method comprises the following steps: taking 1,13-tridecanedioic acid as a raw material; preparing 1,13-tridecylamine through cyanation and amination; preparing PA1313 salt by taking 1,13-tridecylamine and 1,13-tridecanedioic acid as raw materials and water as a solvent; putting PA1313 salt and water at a certain ratio into a polymerizing kettle; performing melt polymerization, thereby acquiring PA1313 with a certain molecular weight. In the cyanation step of the method, an ammonia gas recycling technique is adopted, so that the use ratio of ammonia gas is greatly increased and the emission of wastewater and exhaust gas is reduced; in the salt forming and polymerizing process, water is used forreplacing ethyl alcohol as a reaction medium, so that the safety of industrial production is promoted, the safety level of equipment is reduced, the investment in equipment is reduced and the recycling cost of solvent is lowered.

The invention relates to a preparation method of adiponitrile. The preparation method comprises the following steps: firstly performing a reaction on adipic acid and ammonia at 155-200 DEG C to produce diammonium adipate, and then dehydrating under a catalytic reaction of phosphoric acid or ammonium phosphate to produce adiponitrile; a product can be further separated in a separation tower. The reaction is performed on the adipic acid and the ammonia gas at the low temperature of 155-200 DEG C to produce H4NOOC(CH2)4COONH4 first, and then high-temperature cyanation is performed, so that the opportunity of producing a by-product and a coke from the adipic acid at high temperature is effectively avoided, not only the yield is increased by 3-5%, but also the operation cycle of a production device is prolonged by 30-60 days, and the production per unit time is increased. Liquid phosphoric acid is used as a catalyst, firstly ammonium salt of the phosphoric acid is produced, and the ammoniumphosphate can be mixed with ammonium salt of the adipic acid very well, so that the catalytic performance is improved better and the selectivity of the adiponitrile is increased by more than 2%.

The invention discloses a method for producing a furan ammonium salt by using furoic acid. The method comprises the following steps of: (1) chlorination: putting furoic acid and chlorohydrocarbon solvent into an enameled glass reaction kettle, controlling temperature and time, and obtaining a furoyl chloride product; (2) cyanation: putting the furoyl chloride and sodium cyanide into the reaction kettle, stirring, preserving heat, reducing pressure, and reclaiming the solvent to obtain a furoyl nitrile product; (3) hydrolysis: heating the furoyl nitrile and hydrochloric acid, and obtaining furan ketone acid after the reaction is finished; (4) condensation: adding ethyl acetate extract of the furan ketone acid serving as the hydrolysis product into the reaction kettle, dropping methoxyamine to perform room temperature reaction with the hydrolysis product, and demixing, wherein the oil layer is used for ammoniation reaction; and (5) ammoniation: introducing ammonia gas into the oil layer reactant, controlling the temperature, stirring, finishing gas introduction, centrifuging, and drying to obtain the furan ammonium salt. The method is simple and convenient, is convenient to operate, reduces the production cost, improves the yield, makes full use of raw materials, and is safe and reliable in the production process.

The invention discloses a treatment method of gold extraction cyaniding wastewater containing copper and iron ions with a high concentration. The treatment method comprises the steps of with zinc salt as a precipitator, removing a most part of free cyanogens and copper, iron and zinc ions in a solution, and further recovering residual cyanogens ions and other valuable metal ions in the solution after precipitation by using strong basic resin as an adsorbent to enable the wastewater to be discharged up to the standard. Due to the adoption of the treatment method, cyanide and the valuable metal ions in the gold extraction wastewater are furthest recovered by virtue of the two-step process of precipitation and resin adsorption; and moreover, as the treated wastewater can return to a leaching system or be directly discharged according to the needs, the treatment method is very strong in the flexibility, is low in treatment cost for treating the cyaniding wastewater with higher copper and iron contents and has a remarkable economic benefit.

The present invention discloses a solvent process for synthesizing cartap, comprising that a monosultap alkaline aqueous solution and sodium cyanide undergo a cyanation reaction in a halohydrocarbon solvent and at a temperature of between 20 DEG C below zero and 80 DEG C to give an intermediate thiocyanide solution; and then, the intermediate thiocyanide solution together with methanol and hydrochloric acid gas undergoes a hydrolysis reaction at a temperature of between 50 DEG C below zero and 100 DEG C, for 2 to 30 hours, to give a crude product of the cartap. The method solves the problems in the production of complex process, serious three wastes, instable product yield and instable quality, etc. The method can be suitable for large-scale industrialized and commercialized production.