104results about How to "Good transdermal effect" patented technology

The invention discloses a nano-emulsion medicine for treating foot rot. The grain diameter of the nano-emulsion is in a range of 1-100 nanometers and the nano-emulsion is composed of the following raw materials: 0.1-10.0% of pine tar, 0.1-6.0% of cinnamyl aldehyde, 0.1-6.0% of carvacrol, 0.1-5.0% of camphor oil, 0.01-0.1% of clobetasol propionate, 18.0-35.0% of surfactant, 0-7.0% of co-surfactant and residual amount of distilled water; and the sum of the mass percentages of the components is 100%. The nano-emulsion disclosed by the invention has the functions of dissolving cutin, relieving itching, diminishing inflammation, restraining, partially disinfecting and resisting corrosion, accelerating absorption and the like, and is mainly used for treating animal foot rot. According to the nano-emulsion medicine for treating the foot rot, the solubility of the medicine is increased, the medicinal stability and the biological utilization rate are improved, the dosage of the medicine is reduced, the skin transmission rate is higher than that of common preparations including a medicinal extract and the like, and the cost is low, so that the nano-emulsion medicine has a wide market prospect in a veterinary medicine field.

The invention provides a full-function facial mask. The facial mask comprises the following components in percentage by mass: 0.01-2 percent of hyaluronic acid, 0.01-1 percent of reduced glutathione, 0.01-2 percent of L-vitamin C, 0.01-2 percent of tranexamic acid, 0.01-2 percent of liquiritigenin, 0.01-5 percent of vitamin E, 0.01-1 percent of EGF lyophilized powder, 0.01-2 percent of active peptide, 0.01-3 percent of SOD, 0.01-2 percent of arbutin, 0.1-2 percent of allantoin, 0.5-5 percent of glycerinum, 0.5-5 percent of propylene glycol and the balance of water, wherein the effective components are independently embedded with liposome or coated with nano-microcapsules before being mixed. The activated effective components of the facial mask are independently coated or embedded with transporters, and are delivered to the corium layer or the superficial corium layer by virtue of transportation of the transporters to achieve the effects of quadruple whitening, triple repairing and double moistening.

The invention discloses wrinkle-removing essence containing recombinant collagen, which belongs to the field of cosmetics. The wrinkle-removing essence is prepared from the following components in percentage by mass: 0.1%-1% of recombinant collagen, 10%-30% of glycerol, 1%-5% of 1, 2-hexanediol, 0.1%-0.5% of sodium hyaluronate, 0.1%-0.5% of polyglutamic acid, 0.05%-2% of acetyl hexapeptide-8, 0.03%-2% of elastin, 0.01%-1.5% of fibronectin and the balance of water. The recombinant collagen from microbial fermentation is compounded with other raw materials, so that the problems of precipitation,discoloration, precipitation and the like are avoided. According to the wrinkle-removing essence disclosed by the invention, the recombinant collagen, the sodium hyaluronate, the sodium polyglutamateand the like are compounded for use, so that the effects of tightening and removing wrinkles of the recombinant collagen can be better exerted while moisturizing and water locking are realized.

The invention relates to a ketoprofen gel and a preparation method thereof. The ketoprofen gel is prepared from the following components: 2-5 % of ketoprofen, 0.5-2 % of matrix material, 2-4 % of a transdermal enhancer, 0.5-5 % of a neutralizer, 0.05-0.2 % of an anti-oxidant, 20-50 % of ethanol and the balance being water. The ketoprofen gel provided by the invention solves problems of stimulation of ketoprofen preparations on gastrointestinal tract in a background technology, is used externally, has advantages of good transdermal effect, quick effect and good analgesic and anti-inflammatory effects, and can play drug effects for a long time.

The invention discloses an oil-in-water type compound geranium oil nanometer milk composition. The particle diameter of the composition is 1-100nm. The composite is composed of the following raw materials by weight percentage: 28.5%-42.1% of a surfactant, 0.01%-5.6% of geranium oil, 0.01%-4.6% of evening primrose seed oil, 0.01%-2.8% of cade oil, 0.01%-1.4% of orange flower oil, 0.01%-1.4% of lavender oil and balanced distilled water. The sum of the mass percentage of the raw materials is 100%. The oil-in-water type compound geranium oil nanometer milk composite can obviously treat dermatitis, eczema and pale scar and can alleviate premenstrual syndrome to different degrees, improves biological utilization degree of essential oil, enhances pharmacological activity of the essential oil, enables the essential oil to be strong in permeability, good in stability, durable in acting time and obvious in effect, and has wide market prospect in the field of medicines.

A flexible vitamine A acid liposome for treating dermatopathy is disclosed, which contains lecithin, bile salt, vitamine A acid and solvent. Its medicine in the form of solution, cream, or ointment contains said flexible vitamine A acid liposome, anti-oxidizing agent, and solvent. Its advantages are high stability, durable action, high curative effect, and less or no by-effect.

The invention belongs to the technical field of medicine, and in particular, relates to a flexible liposome containing drugs and a preparation method thereof. Because of the barrier effect of skin, many drugs have low transdermal efficiency and poor absorption. Focusing on the problems, the invention provides the flexible liposome containing the drugs, wherein the flexible liposome is prepared from the flexible liposome-contained drugs modified by hydrophobically modified polypeptide. The specially modified liposome is prepared from the following main raw materials by the weight percentage: according to the weight ratio, the ratio of lecithin to sodium deoxycholate or polysorbate 80 or a derivative thereof is 7:(2-4), and the specially modified liposome contains 0.1-1 wt% of antioxidants,1-10 wt% of a hydrophobically modified polypeptide DP7-C or PAL-DP7 or the derivative thereof, and 1-10 wt% of the contained drugs. The designed and screened flexible liposome hydrophobically modifiedby the polypeptide can effectively carry drugs into a deep layer of skin, helps the drugs to play a role in cells, and has a good application prospect.

The invention discloses an oil-in-water compound cedar oil nano emulsion composition. The particle size of the nano medicine is 1-100nm. The composition is prepared from the following raw materials in percentage by mass: 0.01-5.4% of cedar oil, 0.01-2.7% of bergamot essential oil, 0.01-2.7% of Salvia japonica essential oil, 0.01-1.4% of myrrh essential oil, 0.01-1.3% of cloven essential oil, 30.0-45.0% of surfactant and the balance of distilled water, totaling 100%. The nano emulsion composition has obvious anti-inflammation action, can kill mold, and has excellent curative effects on bronchitis, cough, phlegm and the like.

The invention relates to a chitosan water-retaining gel adhesive substrate materials and method for preparation, which comprises (by weight percentage) chitosan 2.4-16, Na2HPO4*12H2O 1.9-18, ethoxyl cellulose 1.9-18, polyvinyl alcohol 15-80, polyethylene glycol 0.79-21, glycerin 0.54-56, twain 0.44-35, polyvinyl pyrrolidon 0.25-24, menthanol 0.20-8.9, its preparing process comprises mixing, applying, cutting and split charging.

The invention relates to linoleic acid modified glucan and a preparation method of a polymeric liposome. Glucan reacts with linoleic acid to form an amphiphilic high-molecular linoleic acid modified glucan. Then the linoleic acid modified glucan is dissolved in dichloromethane, and prepared into high-molecular liposome according to a reverse evaporation method.

The invention discloses a compound preparation for external use for treating alopecia areata and a preparation method thereof, active ingredients of the compound preparation for external use compriseA and B, the active ingredient A is one or more of a JAK (Janus kinase) inhibitor or a pharmaceutically acceptable salt thereof, and the active ingredient B is minoxidil or a pharmaceutically acceptable salt thereof, drug forms of the preparation for external use comprise emulsion, ointment, emulsifiable paste, tincture, patch, gel, liniment, foaming agent, etc., and the foaming agent is preferred. The compound preparation for external use provided by the invention can act on different targets of alopecia areata pathogenesis through the two components to play a synergetic effect, so that the curative effect on alopecia areata, especially on moderate and severe alopecia areata, is enhanced. Meanwhile, the compound preparation for external use is preferably designed to be the foaming agent with a light texture to be easily and evenly distributed on scalp, so as to improve the applicability to hair parts and the compliance of patients, and solubility and permeability of active ingredientsare increased through drug form improvement, so as to prolong the effective drug duration and reduce the toxic and side effects of the active ingredients.

The present invention provides a mastitis ointment for animals as well as a preparation method and medication thereof. The mastitis ointment is a compound preparation made from ten Chinese medicinal materials with the following weight proportion: 50 to 70g of dandelion, 50 to 70g of tokyo violet herb, 40 to 60g of cortex phellodendri amurensis, 40 to 60g of wild chrysanthemum, 40 to 60g of common selfheal, 40 to 60g of common bletilla, 30 to 50g of earthworm, 30 to 50g of mulberry branch, 30 to 50g of carbonized hair and 30 to 50g of pricklyash berry. The mastitis ointment has the efficacies of clearing toxic heat, promoting blood circulation for removing blood stasis, reducing swelling, discharging pus and removing obstruction in collaterals, which mainly cures earlier acute mastitis, red swelling and thermal pain, carbuncle-abscess and yellowish swelling; moreover, the mastitis ointment is suitable for curing breast diseases of cows, pigs and other livestock such as clinical and recessive mastitis, acromastitis and breast lump, as well as pyogenesis, empyema, breast red swelling and thermal pain, breast skin temperature increase and no latex caused by mechanical and sucking damages. The mastitis ointment based on the production technology of the traditional Chinese black plaster makes certain improvements, thus being more suitable for treatment of cow mastitis.

The invention discloses a wrinkle-removing firming stock solution containing recombinant collagen, which belongs to the field of cosmetics. The wrinkle-removing firming stock solution is prepared fromthe following components in percentage by mass: 0.1%-1% of recombinant collagen, 10%-40% of butanediol, 1%-5% of 1,2-hexanediol, 1%-10% of polyethylene glycol-8, 0.1%-0.5% of sodium hyaluronate, 0.1%-0.5% of polyglutamic acid, 0.05%-2% of acetyl hexapeptide-8 and the balance of water. The recombinant collagen from microbial fermentation is compounded with other raw materials, so that the problemsof precipitation, discoloration, precipitation and the like are avoided. The wrinkle-removing firming stock solution disclosed by the invention not only has excellent moisturizing and water-locking effects on skin, but also has the effects of firming and removing wrinkles.

The invention relates to a skin preparation for external application, which has remarkable efficacies of being anti-inflammatory, relieving itching and sterilizing, and can serve as a treating medicine and / or be used in different forms or different purposes of serving as a disinfector, health article, and the like, for assisting in treatment. The skin preparation aims at solving the technical problem of causing active ingredients to be evenly spread in accessorial added ingredients. The main improvement of the skin preparation for external application is that at least one of borneol and menthol is added in an accessory system in a liquid form and other active ingredients are added in the accessory system in a powder form for preparing. After improvement, the skin preparation for external application is easier to be spread evenly, also reduces material loss caused by grinding and simultaneously improves the percutaneous performance of drugs.

The invention discloses a daptomycin ethosome preparation. The prescription comprises 1mg of prescription, 10-20mg of lecithin, 0.6-0.8ml of ethanol and the balance water which are prepared into 2ml of the daptomycin ethosome preparation. A preparation method includes: dissolving the daptomycin in water to prepare daptomycin water solution; dissolving the lecithin in anhydrous ethanol to prepare lecithin ethanol solution; and uniformly mixing the daptomycin water solution and lecithin ethanol solution at the room temperature, performing ice-bath probe ultrasonography with the ultrasonic power of 800W for 20-40minutes, and then enabling the mixture to pass through a microporous homogeneous membrane with the pore diameter of 50-20nm in a homogenizing instrument to enable ethosomes to be dispersed uniformly so that the daptomycin ethosome preparation is prepared. The daptomycin ethosome preparation is a stable translucent dispersion system with light blue opalescence, small and uniform in particle size, high in entrapment efficiency and excellent in transdermal performance and drug release and has certain slow-release effect, and the preparation method is simple and convenient, low in cost and good in stability.

The invention relates to the technical field of medicines, in particular to a medication system. An electret nanoparticle cutaneous penetration system comprises an isolated layer, wherein a drug-contained pressure-sensitive adhesive layer is arranged on the inner side of the isolated layer, an electret layer made of electret materials is arranged on the outer side of the isolated layer, and a controlled release film layer is arranged on the inner side of the drug-contained pressure-sensitive adhesive layer; the electret layer, the isolated layer, the drug-contained pressure-sensitive adhesive layer and the controlled release film layer are arranged in sequence from outside to inside to form a depot patch; tourmaline powder particles are distributed in the drug-contained pressure-sensitive adhesive layer. According to the electret nanoparticle cutaneous penetration system, the tourmaline powder particles are mixed into the drug-contained pressure-sensitive adhesive layer, so that the electret nanoparticle cutaneous penetration system has the advantages of promoting blood circulation of a human body, enhancing the vitality of cells, improving an electret electric field, replenishing mineral substance for the human body and the like.

The invention provides a full-function facial mask. The facial mask comprises the following components in percentage by mass: 0.01-2 percent of hyaluronic acid, 0.01-1 percent of reduced glutathione, 0.01-2 percent of L-vitamin C, 0.01-2 percent of tranexamic acid, 0.01-2 percent of liquiritigenin, 0.01-5 percent of vitamin E, 0.01-1 percent of EGF lyophilized powder, 0.01-2 percent of active peptide, 0.01-3 percent of SOD, 0.01-2 percent of arbutin, 0.1-2 percent of allantoin, 0.5-5 percent of glycerinum, 0.5-5 percent of propylene glycol and the balance of water, wherein the effective components are independently embedded with liposome or coated with nano-microcapsules before being mixed. The activated effective components of the facial mask are independently coated or embedded with transporters, and are delivered to the corium layer or the superficial corium layer by virtue of transportation of the transporters to achieve the effects of quadruple whitening, triple repairing and double moistening.

The invention relates to a traditional Chinese medicinal composition, especially to a traditional Chinese medicinal composition for treating dysmenorrhoea and a preparation thereof. The formula of the composition comprises the following traditional Chinese medicinal raw medicines: 3-6 kg of tarragon, 6-12 kg of Cyperus Rotundus L with vinegar, 3-6 kg of evodia, 3-6 kg of Ligusticum wallichii, 0.5-1.0 kg of cassia twig, 100-400 g of borneol and 1.5-4.5 g of capsicine.

A matrix used for preparing the Babu preparation and various exterior-applied medical pickings are disclosed. Its advantages are high capacity of included medicine, high percutaneous effect and air permeability, controlled slow release and no irritation to skin.

The invention belongs to the field of cosmetics, and in particular relates to a flexible liposome cosmetic containing active small molecular substances and a preparation method thereof. Due to the barrier action of epidermal cuticle of the skin, most active ingredients in cosmetics containing active small molecular substances are difficult to penetrate the skin. In view of the above problem, the present invention provides the flexible liposome cosmetic containing active small molecular substances, a flexible liposome which contains active small molecular substances and is modified by a hydrophobic modifying polypeptide is prepared into the cosmetic so as to effectively improve the penetration rate of the active small molecular substances in the cosmetic and to developed the cosmetic with easier absorption and better anti-oxidation and anti-aging effects. The cosmetic has broad application prospects.

A pulse circulation type transdermal testing apparatus including a transdermal pool with a transdermal liquid and an animal skin sealed on the transdermal pool. A homothermal heat source is arranged below the transdermal pool. A bottom plate of the transdermal pool is tightly stuck on the homothermal heat source. The transdermal pool is provided with a liquid inlet tube and a liquid discharging tube. The liquid inlet tube and the liquid discharging tube form a circulation loop of simulated blood in an organism tissue by a pulse liquid source.

The invention discloses a macromolecule skin penetration enhancer as well as a preparation method and applications thereof. The preparation method comprises the followings step of: linking HP-beta-CD (hydroxypropyl-beta-cyclodextrin) with PEI (polyethyleneimine) by utilizing GMA (glycidyl methacrylate), thereby synthesizing the novel skin penetration enhancer, namely HP-beta-CD-GMA-PEI. Through HP-beta-CD-GMA-PEI treatment, cuticle protein cell viability is improved, so that a keratin accumulation structure becomes loose, and the degree of freedom of the corresponding carbon motion is improved, so that the keratin carbon motion is accelerated. Under the same concentration, compared with azone, the HP-beta-CD-GMA-PEI has a better skin penetration effect, and when the concentration is increased by one time, the skin penetration effect is better.

The invention discloses a fish seed collagen facial mask and a preparation method thereof, and belongs to the technical field of cosmetics composition. Salmon eggs as raw material are degreased by supercritical CO2 extraction, alkaline protease is added, and enzymatic hydrolysis is performed, so various active substances are dissolved, active ingredients are collected, skin cuticula is helped to maintain normal moisture in dry air, and skin is prevented from generating alligatoring, roughness and the like due to moisture deficiency; carbon tetrachloride, glutamic acid and phenylcarbinol are added, N-carboxylic anhydride benzyl glutamate is obtained, amine-terminated polyethylene glycol is used for initiating ring opening polymerization of N-carboxylic anhydride benzyl glutamate, and a surface active additive is synthesized, and nutritional ingredients in the facial mask can be released quickly without losing; with addition of carbomer, swelling of a facial mask gel is facilitated, cellactivity is stimulated, and cell metabolism is enhanced, so that active substances in the facial mask are better absorbed. The problems that conventional collagen is easily dissolved in water to loseand active ingredients are not easily retained and are penetrated into skin are solved.

The invention discloses medicine extract submicron emulsion gel. The medicine extract submicron emulsion gel is prepared from the following raw materials in parts by weight: 20 to 50 parts of cortex moutan, 20 to 50 parts of rhizoma chuanxiong, 10 to 40 parts of safflower, 5 to 60 parts of herba selaginellae and 5 to 60 parts of herba geranii; the medicine extract submicron emulsion gel further comprises 50mg / g to 300mg / g of a medical oil phase, 5mg / g to 50mg / g of an emulsifier, 1mg / g to 50mg / g of an assistant emulsifier, 0.1mg / g to 35mg / g of a stabilizer, 0.1mg / g to 20mg / g of an antioxygen, 5mg / g to 50mg / g of a gel matrix and 0.5mg / g to 3mg / g of a preservative. The medicine extract submicron emulsion gel has the effects of promoting flow of qi and blood circulation, expelling wind and detoxifying, clearing heat and expelling dampness and is used for treating targeted medicine erythra, radiodermatitis and chemotherapeutic extravasation and has high effective rate, small toxic side effect and short course treatment.

The invention provides a method for preparing cataplasm for treating soft tissue injury, and belongs to the technical field of traditional Chinese medicinal pharmacy. The cataplasm is prepared by adding a framework material, a cross-linking agent, a crosslinking regulator, humectant, agglutinant and the like into rhubarb, astragalus and cortex phellodendri serving as traditional Chinese medicinal raw materials. Compared with the conventional medicament for treating the soft tissue injury, the cataplasm for treating the soft tissue injury prepared by the method has the advantages of convenient use, comfort, easy acceptation of patients, convenient application, no extraction of body hair and no phenomena of irritation and allergy, and can be applied to bodies repeatedly. Because gelata has high water content, the medicament has good transdermal effect and quick response.

The invention provides a skin care lotion containing sheep placenta. The skin care lotion is characterized by being consisting of sheep placenta and skin care lotion substrates, wherein the skin carelotion substrates comprise the following components in percentage by mass of 0.05%-0.1% of EDTA-2Na, 0.5%-1% of water-soluble jojoba oil, 0.5%-1% of 3-o-ethyl ascorbicacid, 0.1%-0.5% of nicotinamide,0.01%-0.02% of palmitoyl pentapeptide-4, 0.01-0.02% of acetyl hexapeptide-8, 0.5%-1% of hexylene glycol and the balance distilled water. The invention also discloses an extraction method of the sheepplacenta. The skin care lotion containing sheep placenta disclosed by the invention can alleviate skin wrinkles and delay skin ageing, is notable in transdermal absorption effect and long in quality guarantee period, has predominant whitening effects, is non-irritating to skin, is good in skin elasticity after being used, is excellent in skin care and feature beautifying effects, is wide in adaptability and has high promotion value.

The invention relates to the technical field of skin care products, and in particular to estrogen gel and a preparation method thereof. The estrogen gel is prepared from a main material and an auxiliary material, wherein the main material is prepared from estradiol, L40 or azone and carbopol; the auxiliary material is prepared from ethanol, propanediol, distilled water and triethanolamine. The estrogen gel disclosed by the invention has the following beneficial effects that the main material is a basic material and an important composition in gel, the main material plays a key role during use, the estrogen gel can be used for conditioning menoxenia, enlarging breasts, carrying out postpartum care, assisting reproduction, increasing sexual life quality, beautifying and resisting aging, preventing climacteric syndrome, regulating climacteric symptoms, improving metabolism and reducing abdominal fat accumulation, and the transdermal effect is good.

The invention discloses a compound external preparation for treating alopecia areata and a preparation method thereof, the compound external preparation comprises an active component A and an active component B, the active component A is one or more of a JAK (Janus kinase) inhibitor or pharmaceutically acceptable salts thereof, and the active component B is minoxidil or pharmaceutically acceptable salts thereof. The compound external preparation is good in drug effect, good in solubility and good in storage stability. The preparation method is simple to operate, and the solubility, the dissolution speed and the placement stability of the active ingredients are improved.

The invention aims to provide a sinomenine preparation. The preparation is prepared from sinomenine with a proper concentration, ostrich oil, vitamin E with a proper concentration and eucalyptus oil. The preparation method comprises the following steps: heating and melting the ostrich oil into liquid; adding sinomenine powder, and uniformly stirring and dispersing; adding eucalyptus oil and vitamin E, stirring and cooling. According to the preparation, the transdermal effect of sinomenine can be improved and the drug effect of the medicine can be improved; ostrich oil is a pure natural raw material, is capable of reducing skin irritation when used as a drug-loading matrix; in addition, ostrich oil has arthritis resistance and can realize arthritis treatment when used together with sinomenine.

A Chinese medicine in the form of plaster for treating osteogeny, rheumatic arthritis, lumbar intervertebral disk protrusion, soft tissue injury and the pains of muscle and bone is prepared from 14 Chinese-medicinal materials including Sichuan aconite root, wild aconite root, pinellia tuber, pangolin scales, etc.