Medicine extract submicron emulsion gel and preparation method of medicine extract submicron emulsion gel

An extract and sub-microemulsion technology, applied in the field of medicine, can solve the problems of inconvenient use of outpatients, prone to venous thrombosis, application of traditional Chinese medicine preparations, etc., and achieve the effects of improving skin penetration rate, good patient response, and high drug loading capacity.

Inactive Publication Date: 2017-05-31
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

causing great pain to the patient
[0008] Although the catheterization method can reduce the phenomenon of skin damage caused by extravasation of chemotherapeutic drugs, it is easy to cause venous thrombosis and increase the risk of infection, and the operation is cumbersome (professional dressing change and tube sealing are required), which makes it inconvenient for outpatients to use. Intravenous infusion is still the main form of chemotherapy
In view of the above problems, there is no recognized and effective relevant traditional Chinese medicine preparation for clinical application, and it is urgent to develop new preparations for the treatment of extravasation of chemotherapy drugs to ensure the smooth progress of chemotherapy.

Method used

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  • Medicine extract submicron emulsion gel and preparation method of medicine extract submicron emulsion gel
  • Medicine extract submicron emulsion gel and preparation method of medicine extract submicron emulsion gel
  • Medicine extract submicron emulsion gel and preparation method of medicine extract submicron emulsion gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Raw materials:

[0030] Cortex paeonol 18g, Rhizoma Chuanxiong 18g, safflower 12g, Phellodendron 20g, geranium 20g, five-flavored traditional Chinese medicine soybean oil 10g, soybean lecithin 80H 2.5g, Tween-80 3.5g, oleic acid 0.15g, vitamin E 0.01g, Carbomer 940 2.0g, ethylparaben 0.2g;

[0031] (2) Preparation process:

[0032] ① Take paeonol, chuanxiong, safflower, Phellodendron phellodendri, and geranium, and decoct them with water for 1 hour to obtain an aqueous solution of the extract. After dissolving, add it to the aqueous extract solution to make a water phase, and keep it at 60°C for later use;

[0033] ②At 60°C, use ethanol to soak the decocted traditional Chinese medicine for 1 hour to obtain its organic solvent extract, then add oleic acid, soybean lecithin, vitamin E and soybean oil to the organic solvent extract to dissolve, and then At 40°C, remove the organic solvent under reduced pressure, heat to 60°C, stir evenly, and make an oil phase;

[...

Embodiment 2

[0039] (1) Raw materials:

[0040] Cortex paeonol 36g, Rhizoma Chuanxiong 36g, safflower 24g, Phellodendron 5g, geranium 5g Five herbs, medium chain triglyceride 10g, egg yolk lecithin 4.5g, Tween-80 1.5g, oleic acid 0.1g, vitamin E 0.1 g, Carbomer 934 2.0g, Methylparaben 0.1g

[0041] (2) Preparation process:

[0042] ① Take paeonol, chuanxiong, safflower, Phellodendron phellodendri, and geranium, and decoct them with water for 1 hour to obtain an aqueous solution of the extract. After dissolving, add it to the aqueous extract solution to make a water phase, and keep it at 80°C for later use;

[0043] ②At 50°C, use ethyl acetate to soak the decocted traditional Chinese medicine for 30 minutes to obtain its organic solvent extract, then add egg yolk lecithin, vitamin E, medium-chain triglycerides, and oleic acid to the organic solvent extract Dissolve in medium, remove the organic solvent under reduced pressure at 30°C, heat to 80°C, stir evenly, and make an oil phase;

[...

Embodiment 3

[0049] (1) Raw materials:

[0050] Dan cortex 20g, Chuanxiong 20g, safflower 16g, Phellodendron 60g, geranium 60g, five traditional Chinese medicines, castor oil 20g, egg yolk lecithin 1.5g, poloxamer 4.5g, oleic acid 0.1g, vitamin E 0.25g, HPMC 5.0 g, sodium benzoate 0.3g;

[0051] (2) Preparation process:

[0052] ① Take paeonol, chuanxiong, safflower, Phellodendron phellodendri, and geranium, and decoct them with water for 1 hour to obtain an aqueous solution of the extract. Dissolve sodium benzoate in 5ml of water and add it to the aqueous extract solution. Add poloxamer Dissolve in the extract, make water phase, and keep it at 55°C for later use;

[0053] ② Dissolve oleic acid, egg yolk lecithin, vitamin E and the castor oil into the castor oil phase, heat to 55°C, stir evenly, and make the oil phase;

[0054] ③At 55°C, slowly inject the oil phase into the water phase while stirring, and use a high-shear dispersing emulsifier at a speed of 20,000 rpm to stir rapidly fo...

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Abstract

The invention discloses medicine extract submicron emulsion gel. The medicine extract submicron emulsion gel is prepared from the following raw materials in parts by weight: 20 to 50 parts of cortex moutan, 20 to 50 parts of rhizoma chuanxiong, 10 to 40 parts of safflower, 5 to 60 parts of herba selaginellae and 5 to 60 parts of herba geranii; the medicine extract submicron emulsion gel further comprises 50mg/g to 300mg/g of a medical oil phase, 5mg/g to 50mg/g of an emulsifier, 1mg/g to 50mg/g of an assistant emulsifier, 0.1mg/g to 35mg/g of a stabilizer, 0.1mg/g to 20mg/g of an antioxygen, 5mg/g to 50mg/g of a gel matrix and 0.5mg/g to 3mg/g of a preservative. The medicine extract submicron emulsion gel has the effects of promoting flow of qi and blood circulation, expelling wind and detoxifying, clearing heat and expelling dampness and is used for treating targeted medicine erythra, radiodermatitis and chemotherapeutic extravasation and has high effective rate, small toxic side effect and short course treatment.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a drug extract submicron emulsion gel and a preparation method thereof. Background technique [0002] Targeted drugs are playing an increasingly important role in the field of tumor treatment. While they bring significant curative effects, they also cause treatment-related adverse reactions, especially skin toxicity, which not only affects the quality of life of patients, but may also affect the quality of life of patients in severe cases. follow-up treatment. The incidence of skin toxicity is higher than 50%, of which about 10% are severe. Manifestations include dry skin, hyperpigmentation, itching, desquamation, papulopustular lesions (i.e., comedones or acneiform rashes), nail / periungal changes (usually paronychia), abnormal hair growth (usually alopecia, Thick and long eyelashes or facial hair), telangiectasia (usually manifested as the expansion of small blood vessels), etc. Among...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/06A61K47/44A61P17/00
CPCA61K9/0014A61K9/06A61K36/185A61K36/236A61K36/286A61K36/65A61K36/71A61K36/756A61K47/44A61K2236/331A61K2236/333A61K2300/00
Inventor 陈伟李国辉田爱平王宇谢兰桂梁积新
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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