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Chitosan water-retaining gel adhesive substrate materials and method for preparing same

A technology of hydrogel patch and matrix material, which is applied in the direction of pharmaceutical formula, medical preparation of non-active ingredients, sheet-like delivery, etc. It can solve the problem of small effective drug storage capacity, poor drug transdermal effect, uncontrollable viscosity, etc. problem, to achieve the effects of no toxic and side effects, high water retention performance, and large drug storage capacity

Inactive Publication Date: 2005-09-07
徐放
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional plaster mainly uses rubber plaster as the matrix material. This matrix material is large and thin in appearance, and its disadvantages are small effective drug storage capacity, airtightness, poor transdermal effect of drugs, easy irritation and allergies, inability to relieve drug potency, and high viscosity. regulation, and generally can only load fat-soluble drugs, which greatly limits the development of plasters
Traditional gel patches with high matrix content and low water retention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The components and weight percentages of the chitosan water-retaining gel patch matrix material are: chitosan 6.49, disodium hydrogen phosphate dodecahydrate 6.49, hydroxyethyl cellulose 6.49, polyvinyl alcohol 43.29, polyethylene glycol 6.49 , Glycerin 13.64, Tween 11.70, Polyvinylpyrrolidone 4.33, Menthol 1.08.

[0032] The raw material that adopts in this example: chitosan: degree of deacetylation 90.1%, viscosity 430mPa S; Hydroxyethyl cellulose: viscosity about 1500mPa S (5% concentration in aqueous solution); Polyvinyl alcohol 124; Polyethylene glycol 8000; Tween 80; polyvinylpyrrolidone K30, biochemical reagent; disodium hydrogen phosphate dodecahydrate, analytically pure; glycerin, analytically pure; menthol, pharmaceutical grade.

[0033] Its preparation method is as follows:

[0034] 1) prepare 1.0% (v / v) ethanol 0.5% (v / v) acetic acid aqueous solution system, dissolve chitosan with this solution system, prepare the chitosan solution that concentration is 1.5...

Embodiment 2

[0044] The components and weight percentages of the chitosan water-retaining gel patch matrix material are: chitosan 11.77, disodium hydrogen phosphate dodecahydrate 11.77, hydroxyethyl cellulose 11.77, polyvinyl alcohol 43.93, polyethylene glycol 1.37 , Glycerin 8.65, Tween 7.41, Polyvinylpyrrolidone 1.96, Menthol 1.37.

[0045] The raw material that adopts in this example: chitosan: degree of deacetylation 89%, viscosity 500mPa S; Hydroxyethyl cellulose: viscosity about 1500mPa S (5% concentration in aqueous solution); Polyvinyl alcohol 124; Polyethylene glycol 6000; Tween 20; polyvinylpyrrolidone K30, biochemical reagent; disodium hydrogen phosphate dodecahydrate, analytically pure; glycerin, analytically pure; menthol, pharmaceutical grade.

[0046] Its preparation method is as follows:

[0047] 1) prepare 1.0% (v / v) ethanol 0.5% (v / v) acetic acid aqueous solution system, dissolve chitosan with this solution system, prepare the chitosan solution that concentration is 1.5%...

Embodiment 3

[0057] The components and weight percentages of the chitosan water-retaining gel patch matrix material are: chitosan 3.30, disodium hydrogen phosphate dodecahydrate 3.30, hydroxyethyl cellulose 3.30, polyvinyl alcohol 34.34, polyethylene glycol 7.15 , Glycerin 22.54, Tween 19.32, Polyvinylpyrrolidone 4.96, Menthol 1.79.

[0058] The raw material that adopts in this example: chitosan: degree of deacetylation 91%, viscosity 560mPa S; Hydroxyethyl cellulose: viscosity about 1500mPa S (5% concentration in aqueous solution); Polyvinyl alcohol 124; Polyethylene glycol 10000; Tween 80; polyvinylpyrrolidone K30, biochemical reagent; disodium hydrogen phosphate dodecahydrate, analytically pure; glycerin, analytically pure; menthol, pharmaceutical grade.

[0059] Its preparation method is as follows:

[0060] 1) prepare 1.0% (v / v) ethanol 0.5% (v / v) acetic acid aqueous solution system, dissolve chitosan with this solution system, prepare the chitosan solution that concentration is 1.5%...

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Abstract

The invention relates to a chitosan water-retaining gel adhesive substrate materials and method for preparation, which comprises (by weight percentage) chitosan 2.4-16, Na2HPO4*12H2O 1.9-18, ethoxyl cellulose 1.9-18, polyvinyl alcohol 15-80, polyethylene glycol 0.79-21, glycerin 0.54-56, twain 0.44-35, polyvinyl pyrrolidon 0.25-24, menthanol 0.20-8.9, its preparing process comprises mixing, applying, cutting and split charging.

Description

technical field [0001] The invention relates to a chitosan water-retaining gel patch matrix material and a preparation method thereof. Background technique [0002] Plaster is an important part of traditional medicine in my country. It has a history of more than 2,000 years. It has advantages that other dosage forms cannot match. It is easy to use, can be administered continuously, and can be interrupted at any time. However, the traditional plaster mainly uses rubber plaster as the matrix material. This matrix material is large and thin in appearance, and its disadvantages are small effective drug storage capacity, airtightness, poor transdermal effect of drugs, easy irritation and allergies, inability to relieve drug potency, and high viscosity. Regulation, and generally only fat-soluble drugs can be loaded, which greatly limits the development of plasters. Traditional gel patches have high matrix content and low water retention. Contents of the invention [0003] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/36C08L29/04C08L39/06
Inventor 徐放
Owner 徐放
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